Dekker, Lodewijk - University of Nottingham

个人简介

I was educated at Utrecht University, the Netherlands, where I completed my PhD in Molecular Neurobiology in 1989 in the Institute for Molecular Biology and the Rudolf Magnus Institute of Pharmacology in Utrecht. During this period I investigated the role of protein phosphorylation in synaptic function. I then undertook postdoctoral research at the Novartis Institute for Medical Research, the Imperial Cancer Research Fund and University College in London. My research was in the area of cell signaling and focused largely on the Protein Kinase C pathway. In 2001 I joined Ionix Pharmaceuticals Ltd in Cambridge as Head of Molecular Biology and then became Head of Molecular Pharmacology and Associate Director of Pharmacology. In this capacity I was project leader of an early stage drug discovery project targeting voltage gated sodium channels to develop novel analgesics. In 2005 I joined the School of Pharmacy in Nottingham as Senior Lecturer in the Division of Medicinal Chemistry and Structural Biology. My research has yielded scientific publications which to date have been cited in excess of 3500 times (h-index: 29 (ISI); 34 (RG)).

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

DISNEY AJ, KELLAM B and DEKKER LV, 2016. Alkylation of Staurosporine to Derive a Kinase Probe for Fluorescence Applications. ChemMedChem. 11(9), 972-9 LIU Y, MYRVANG HK and DEKKER LV, 2015. Annexin A2 complexes with S100 proteins: structure, function and pharmacological manipulation. British journal of pharmacology. 172(7), 1664-1676 PATHAK M, WILMANN P, AWFORD J, LI C, HAMAD BK, FISCHER PM, DREVENY I, DEKKER LV and EMSLEY J, 2015. Coagulation factor XII protease domain crystal structure. Journal of thrombosis and haemostasis : JTH. 13(4), 580-591 REDDY, T.R.K., LI, C., GUO, X., FISCHER, P.M. and DEKKER, L.V., 2014. Design, Synthesis and SAR Exploration of Tri-substituted 1,2,4-Triazoles as Inhibitors of the Annexin A2-S100A10 Protein Interaction Bioorganic and Medicinal Chemistry. 22(19), 5378-5391 MYRVANG, H.K., GUO, X., LI, C. and DEKKER, L.V., 2013. Protein interactions between surface annexin A2 and S100A10 mediate adhesion of breast cancer cells to microvascular endothelial cells FEBS Letters. 587(19), 3210-3215 ECCLES ET AL, 2013. Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer Breast Cancer research. 15(5), R92 REDDY, T.R.K., LI, C., FISCHER, P.M. and DEKKER, L.V., 2012. Three-dimensional pharmacophore design and biochemical screening identifies substituted 1,2,4-triazoles as inhibitors of the annexin A2-S100A10 protein interaction ChemMedChem. 7(8), 1435-1446 MOHAMMED, M.Z., VYJAYANTI, V.N., LAUGHTON, C.A., DEKKER, L.V., FISCHER, P.M., WILSON, D.M., ABBOTTS, R., SHAH, S., PATEL, P.M., HICKSON, I.D. and MADHUSUDAN, S., 2011. Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines British Journal of Cancer. 104(4), 653-663 REDDY, T.R.K., LI, C., GUO, X., MYRVANG, H.K., FISCHER, P.M. and DEKKER, L.V., 2011. Design, synthesis, and SAR exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2–S100A10 protein interaction Journal of Medicinal Chemistry. 54(7), 2080-2094 REDDY, T.R.K., LI, C., FISCHER, P.M. and DEKKER, L.V., 2011. Preparation of pyrrole derivatives as S100 protein binding interaction inhibitors for treatment of cancer and other diseases WO2011092505 A1 WO2011-GB50137 GB2010-1596 WO 2011092505 08/04/2011 00:00:00 LI, C., REDDY, T.R.K., FISCHER, P.M. and DEKKER, L.V., 2010. A Cy5-labelled S100A10 tracer used to identify inhibitors of the protein interaction with Annexin A2 ASSAY and Drug Development Technologies. 8(1), 85-95 SHAO, D., SEGAL, A.W. and DEKKER, L.V., 2010. Subcellular localisation of the p40phox component of NADPH oxidase involves direct interactions between the Phox homology domain and F-actin International Journal of Biochemistry and Cell Biology. 42(10), 1736-1743 REDDY, T.R.K., LI, C., GUO, X., FISCHER, P.M. and DEKKER, L.V., 2010. Structure-based design, synthesis, and SAR exploration of pyrrole-2-one analogues as inhibitors of the annexin A2-S100A10 protein interaction: potential anti-angiogenesis therapeutics. Journal of Pharmacy and Pharmacology. 62(10), 1373-1374 PACLET, M.H., DAVIDSON-MONCADA, J., LOPEZ-LLUCH, G., SHAO, D. and DEKKER, L.V., 2009. Protein Kinase C as an effector of lipid-derived second messengers. In: LARIJANI, B., WOSCHOLSKI, R. and ROSSER, C.A., eds., Lipid signalling protocols 462. Humana Press Inc, Totowa, USA. 253-263 DEKKER, L.V., 2008. Novel approaches to drug discovery in signal transduction The Biotechnology Journal. 3(4), 428-429 DEKKER, LODEWIJK V, DANIELS, ZOE, HICK, CAROLINE, ELSEGOOD, KATHRYN, BOWDEN, SARAH, SZESTAK, TADGE, BURLEY, J RUSSELL, SOUTHAN, ANDY, CRONK, DAVID and JAMES, IAIN F, 2005. Analysis of human Nav1.8 expressed in SH-SY5Y neuroblastoma cells. European Journal of Pharmacology. 528(1-3), 52-8 BROWN, SEAN G, THOMAS, ALISON, DEKKER, LODEWIJK V, TINKER, ANDREW and LEANEY, JOANNE L, 2005. PKC-delta sensitizes Kir3.1/3.2 channels to changes in membrane phospholipid levels after M3 receptor activation in HEK-293 cells. American Journal of Physiology: Cell Physiology. 289(3), C543-56 RENAULT, MARIE-ANGE, JALVY, SANDRA, POTIER, MYLÃ¨NE, BELLOC, ISABELLE, GENOT, ELISABETH, DEKKER, LODEWIJK V, DESGRANGES, CLAUDE and GADEAU, ALAIN-PIERRE, 2005. UTP induces osteopontin expression through a coordinate action of NFkappaB, activator protein-1, and upstream stimulatory factor in arterial smooth muscle cells. Journal of Biological Chemistry. 280(4), 2708-13 DEKKER,L.V. and CRONK,D., 2005. Nav1.8 as a drug target for pain. In: COWARD,K. and BAKER,M.D., eds., Sodium channels, pain and analgesia BirkhÃ¤user Publishing Ltd, Basel, CHE. 123-144 PACLET, M.-H., DAVIS, C., KOTSONIS, P., GODOVAC-ZIMMERMANN, J., SEGAL, A.W. and DEKKER, L.V., 2004. N-Formyl peptide receptor subtypes in human neutrophils activate L-plastin phosphorylation through different signal transduction intermediates. Biochemical Journal. 377(2), 469-477 BIRCH, PHILLIP J, DEKKER, LODEWIJK V, JAMES, IAIN F, SOUTHAN, ANDREW and CRONK, DAVID, 2004. Strategies to identify ion channel modulators: current and novel approaches to target neuropathic pain. Drug Discovery Today. 9(9), 410-8 DEKKER,L.V., 2004. Introduction. In: Protein Kinase C 2nd. Kluwer Academic/Plenum Publishers, New York, USA. 1-7 DEKKER, L.V., ed., 2004. Protein Kinase C 2nd. Kluwer Academic/Plenum Publishers, New York, USA. DEKKER,L.V., 2004. Protein Kinase C isotype function in neutrophils. In: Protein Kinase C 2nd. Kluwer Academic/Plenum Publishers, New York, USA. 165-190 SHAO, D., SEGAL, A.W. and DEKKER, L.V., 2003. Lipid rafts determine efficiency of NADPH oxidase activation in neutrophils FEBS Letters. 550(1-3), 101-106