de Moor, Cornelia - University of Nottingham

个人简介

In 2000, she started her own laboratory as a lecturer in the School of Biomedical Sciences at the University of Nottingham, transferring to the School of Pharmacy in 2005. In 2013, she was promoted to associate professor. Most of her current work is on the role of mRNA polyadenylation in gene expression and the therapeutic potential of the polyadenylation inhibitor cordycepin, which is isolated from the caterpillar fungus Cordyceps militaris.

近期论文

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KAPPEL, CHRISTIAN, TROST, GERDA, CZESNICK, HJOERDIS, RAMMING, ANNA, KOLBE, BENJAMIN, VI, SON LANG, BISPO, CLAUDIA, BECKER, JOERG D., DE MOOR, CORNELIA and LENHARD, MICHAEL, 2015. Genome-Wide Analysis of PAPS1-Dependent Polyadenylation Identifies Novel Roles for Functionally Specialized Poly(A) Polymerases in Arabidopsis thaliana PLOS GENETICS. 11(8), LENHARD, MICHAEL, KAPPEL, CHRISTIAN, TROST, GERDA, CZESNICK, H, RAMMING, ANNA, VI, SON L, BISPO, C, BECKER, JD and DE MOOR, CORNELIA, 2015. GSM1386775: Ler - sample 1 - long fraction Gene Expression Omnibus. LENHARD, MICHAEL, KAPPEL, CHRISTIAN, TROST, GERDA, CZESNICK, H, RAMMING, ANNA, VI, SON L, BISPO, C, BECKER, JD and DE MOOR, CORNELIA, 2015. GSM1386776: Ler - sample 1 -short fraction Gene Expression Omnibus. EDWARDS, J.M., LONG, J., DE MOOR, C.H., EMSLEY, J. and SEARLE, M.S., 2013. Structural insights into the targeting of mRNA GU-rich elements by the three RRMs of CELF1 Nucleic Acids Research. 41(14), 7153-7166 CHARLESWORTH, AMANDA, MEIJER, HEDDA A. and DE MOOR, CORNELIA H., 2013. Specificity factors in cytoplasmic polyadenylation WILEY INTERDISCIPLINARY REVIEWS-RNA. 4(4), 437-461 KONDRASHOV, A., MEIJER, H.A., BARTHET-BARATEIG, A., PARKER, H.N., KHURSHID, A., TESSIER, S., SICARD, M., KNOX, A.J., PANG, L. and DE MOOR, C.H., 2012. Inhibition of polyadenylation reduces inflammatory gene induction RNA. 18(12), 2236-2250 MEIJER, HEDDA A and DE MOOR, CORNELIA H, 2011. Fractionation of mRNA based on the length of the poly(A) tail. Methods in molecular biology (Clifton, N.J.). 703, 123-35 EDWARDS, J., MALAURIE, E., KONDRASHOV, A., LONG, J., DE MOOR, C.H., SEARLE, M.S. and EMSLEY, J., 2011. Sequence determinants for the tandem recognition of UGU and CUG rich RNA elements by the two N-terminal RRMs of CELF1 Nucleic Acids Research. 39(19), 8638-8650 JAMES, V., ZHANG, Y., FOXLER, D.E., DE MOOR, C.H., KONG, Y.W., WEBB, T.M., SELF, T.J., FENG, Y., LAGOS, D., CHU, C.-Y., RANA, T.M., MORLEY, S.J., LONGMORE, G.D., BUSHELL, M. and SHARP, T.V., 2010. LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing Proceedings of the National Academy of Sciences of the United States of America. 107(28), 12499-12504 WONG, Y.Y., MOON, A., DUFFIN, R., BARTHET-BARATEIG, A., MEIJER, H.A., CLEMENS, M.J. and DE MOOR, C.H., 2010. Cordycepin inhibits protein synthesis and cell adhesion through effects on signal transduction Journal of Biological Chemistry. 285(4), 2610-2621 KONG, Y.W., CANNELL, I.G., DE MOOR, C.H., HILL, K., GARSIDE, P.G., HAMILTON, T.L., MEIJER, H.A., DOBBYN, H.C., STONELEY, M., SPRIGGS, K.A., WILLIS, A.E. and BUSHELL, M., 2008. The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene Proceedings of the National Academy of Sciences of the United States of America. 105(26), 8866-8871 DOBBYN, H.C., HILL, K., HAMILTON, T.L., SPRIGGS, K.A., PICKERING, B.M., COLDWELL, J., DE MOOR, C.H., BUSHELL, M. and WILLIS, A.E., 2008. Regulation of BAG-1 IRES-mediated translation following chemotoxic stress Oncogene. 27, 1167-1174 COBBOLD, LAURA C, SPRIGGS, KEITH A, HAINES, STEPHEN J, DOBBYN, HELEN C, HAYES, CHRISTOPHER, DE MOOR, CORNELIA H, LILLEY, KATHRYN S, BUSHELL, MARTIN and WILLIS, ANNE E, 2008. Identification of internal ribosome entry segment (IRES)-trans-acting factors for the Myc family of IRESs. Molecular and cellular biology. 28(1), 40-9 RADFORD, HELOIS E, MEIJER, HEDDA A and DE MOOR, CORNELIA H, 2008. Translational control by cytoplasmic polyadenylation in Xenopus oocytes. Biochimica et Biophysica Acta. 1779(4), 217-29 MEIJER, H.A., RADFORD, H.E., WILSON, L.S., LISSENDEN, S. and DE MOOR, C.H., 2007. Translational control of maskin mRNA by its 3' untranslated region Biology of the Cell. 99(5), 239-250 MEIJER, HEDDA A, BUSHELL, MARTIN, HILL, KIRSTI, GANT, TIMOTHY W, WILLIS, ANNE E, JONES, PETER and DE MOOR, CORNELIA H, 2007. A novel method for poly(A) fractionation reveals a large population of mRNAs with a short poly(A) tail in mammalian cells. Nucleic Acids Research. 35(19), e132 DE MOOR, C.H., MEIJER, H. and LISSENDEN, S., 2005. Mechanisms of translational control by the 3' UTR in development and differentiation. Seminars in Cell & Developmental Biology. 16(1), 49-58 DE MOOR, C.H. and RICHTER, J.D., 2001. Translational control in vertebrate development. International Review of Cytology. 203, 567-608 DE MOOR, C H and RICHTER, J D, 1999. Cytoplasmic polyadenylation elements mediate masking and unmasking of cyclin B1 mRNA. EMBO Journal. 18(8), 2294-303 STEBBINS-BOAZ, B, CAO, Q, DE MOOR, C H, MENDEZ, R and RICHTER, J D, 1999. Maskin is a CPEB-associated factor that transiently interacts with elF-4E. Molecular Cell. 4(6), 1017-27 DE MOOR, C H and RICHTER, J D, 1997. The Mos pathway regulates cytoplasmic polyadenylation in Xenopus oocytes. Molecular and Cellular Biology. 17(11), 6419-26