De Matteis, Cristina - University of Nottingham

个人简介

Between 1998 and 2004 I worked as a consultant in visual science communication, with a variety of organizations including the BBC, Nesta, EPSRC (Engineering and Physical Sciences Research Council) and the RSC (Royal Society of Chemistry). In 1996 I won the Science Communicator Award from the BBSRC (Biotechnology and Biological Sciences Research Council), between 1998 and 1999 I was involved in exhibition design and development at a new Science Centre called Explore in Bristol and between 2001 and 2004 I chaired the Royal Society of Chemistry Committee for Promoting Chemistry to the Public.

研究领域

My research interests focus on the study of proteins and their interactions using both experimental and computational techniques. These studies range from exploring how proteins crystallize, and how their crystallization can be improved, to studies of ligand binding to enzymes, including an exploration of chemical mechanism at the active site. My work utilizes a combination of experimental techniques, including X-ray crystallography, and NMR spectroscopy and computational approaches, including virtual screening.

近期论文

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DE MATTEIS C.I., SIMPSON D.A., EUERBY M.R., SHAW P.N. and BARRETT D.A., 2012. Chromatographic retention behaviour of monosubstituted benzene derivatives on porous graphitic carbon and octadecyl-bonded silica studied using molecular modelling and quantitative structure–retention relationships Journal of Chromatography. A. 1229, 95-106 DUFOUR, M., YAN, C., SIEGEL, D., COLUCCI, M.A., JENNER, M., OLDHAM, N.J., GOMEZ, J., REIGAN, P., LI, Y., DE MATTEIS, C.I., ROSS, D. and MOODY, C.J., 2011. Mechanism-based inhibition of quinone reductase 2 (NQO2): selectivity for NQO2 over NQO1 and structural basis for flavoprotein inhibition ChemBioChem. 12(8), 1203-1208 DE MATTEIS, C.I., SIMPSON, D.A., DOUGHTY, S.W., EUERBY, M.R., SHAW, P.N. and BARRETT, D.A., 2010. Chromatographic retention behaviour of n-alkylbenzenes and pentylbenzene structural isomers on porous graphitic carbon and octadecyl-bonded silica studied using molecular modelling and QSRR Journal of Chromatography. A. 1217(44), 6987-6993 ABUKHADER, MAJED M, HEAP, JOHN, DE MATTEIS, CRISTINA I, DOUGHTY, STEPHEN W, MINTON, NIGEL and PAOLI, MAX, 2007. Crystallization and preliminary X-ray characterization of the Bacillus amyloliquefaciens YwrO enzyme. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online. 63(Pt 9), 746-50 REID, SD, WILSON, C, DE MATTEIS, CI and LOVE, JB, 2007. Using chiral ligand substituents to promote the formation of dinuclear, double-stranded iron, manganese, and zinc mesocates European Journal of Inorganic Chemistry. 33, 5286-5293 ABUKHADER, M., HEAP, J., DE MATTEIS, C., KELLAM, B., DOUGHTY, S.W., MINTON, N. and PAOLI, M., 2005. Binding of the anticancer prodrug CB1954 to the activating enzyme NQ02 revealed by the crystal structure of their complex Journal of Medicinal Chemistry. 48(24), 7714-7719 HEALD, C.R., STOLNIK, S., DE MATTEIS, C., GARNETT, M.C., ILLUM, L., DAVIS, S.S. and LEERMAKERS, F.A.M., 2003. Characterisation of poly(lactic acid):poly(ethyleneoxide) (PLA:PEG) nanoparticles using the self-consistent theory modelling approach Colloids and Surfaces A: Physicochemical and Engineering Aspects. 212(1), 57-64 HEALD,C.R., STOLNIK-TRENKIC,S., KUJAWINSKI,K.S., DEMATTEIS,C., GARNETT,M.C., ILLUM,L., DAVIS,S.S., PURKISS,S.C., BARLOW,R.J. and GELLERT,P.R., 2002. Poly(lactic acid)-poly(ethylene oxide) (PLA-PEG) nanoparticles: NMR studies of the central solidlike PLA core and the liquid PEG corona Langmuir. 18(9), 3669-3675 DE MATTEIS, C.I., 2002. Small Matters - a series of short films HEALD, C.R., STOLNIK, S., DE MATTEIS, C., GARNETT, M.C., ILLUM, L., DAVIS, S.S. and LEERMAKERS, F.A.M., 2001. Self-consistent field modelling of poly(lactic acid)-poly(ethylene glycol) particles Colloids and Surfaces A: Physicochemical and Engineering Aspects. 179(1), 79-91 DEMATTEIS,C.I. and BLOXAM,L., 2001. A lighting assembly WO0152222 07/01/2001 00:00:00