Chan, Weng - University of Nottingham

个人简介

I gained my PhD from the University of Nottingham in 1988 under the supervision of Professor Barrie Bycroft and Dr Ray Grout. This was followed by a period of postdoctoral training (1988-1992) under the guidance of Barrie Bycroft (Univ Nottingham), Gordon Roberts (Univ Leicester) and Mike Gasson (IFR, Norwich). In 1992, I was appointed to a lectureship at Nottingham, and was promoted to Senior Lecturer in 2000 and then to Reader in Chemical Biology in 2007.

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ZAPOTOCZNA, M., MURRAY, E.J., HOGAN, S., O'GARA, J.P., CHHABRA, S.R., CHAN, W.C., O'NEILL, E. and WILLIAMS, P., 2017. 5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus Journal of Antimicrobial Chemotherapy. 72(3), 744-753 NG, V and CHAN, W.C., 2016. New found hope for antibiotic discovery: lipid II inhibitors Chemistry - A European Journal. 22(36), 12606-12616 LAVADO, A.S., CHAUHAN, V.M., ALHAJ ZEN, A., GIUNTINI, F., JONES, D.R.E., BOYLE, R.W., BEEBY, A., CHAN, W.C. and AYLOTT, J.W., 2015. Controlled intracellular generation of reactive oxygen species in human mesenchymal stem cells using porphyrin conjugated nanoparticles Nanoscale. 7(34), 14525-14531 MURRAY, E.J., CROWLEY, R.C., TRUMAN, A., CLARKE, S.R., COTTAM, J.A., JADHAV, G.P., STEELE, V.R., O'SHEA, P., LINDHOLM, C., COCKAYNE, A., CHHABRA, S.R., CHAN, W.C. and WILLIAMS, P., 2014. Targeting Staphylococcus aureus quorum sensing with nonpeptidic small molecule inhibitors Journal of Medicinal Chemistry. 57(6), 2813-2819 ALHAJ ZEN, A., AYLOTT, J.W. and CHAN, W.C., 2014. An appraisal of the Suzuki cross-coupling reaction for the synthesis of novel fluorescent coumarin derivatives Tetrahedron Letters. 55(40), 5521-5524 CHEN, C.-H., GENAPATHY, S., FISCHER, P.M. and CHAN, W.C., 2014. A facile approach to tryptophan derivatives for the total synthesis of argyrin analogues Organic and Biomolecular Chemistry. 12(48), 9764-9768 ABULATEEFEH, S.R., SPAIN, S.G., THURECHT, K.J., AYLOTT, J.W., CHAN, W.C., GARNETT, M.C. and ALEXANDER, C., 2013. Enhanced uptake of nanoparticle drug carriers via a thermoresponsive shell enhances cytotoxicity in a cancer cell line Biomaterials Science. 1(4), 434-442 GORDON, CHRISTOPHER P., WILLIAMS, PAUL and CHAN, WENG C., 2013. Attenuating Staphylococcus aureus virulence gene regulation: a medicinal chemistry perspective Journal of Medicinal Chemistry. 56(4), 1389-1404 RUDKIN, J.K., EDWARDS, A.M., BOWDEN, M.G., BROWN, E.L., POZZI, C., WATERS, E.M., CHAN, W.C., WILLIAMS, P., O'GARA, J.P. and MASSEY, R.C., 2012. Methicillin resistance reduces the virulence of healthcare-associated methicillin-resistant Staphylococcus aureus by interfering with the agr quorum sensing system Journal of Infectious Diseases. 205(5), 798-806 FERNANDEZ, LETICIA, CHAN, WENG C., EGIDO, MERITXELL, GOMARA, MARIA J. and HARO, ISABEL, 2012. Synthetic peptides derived from an N-terminal domain of the E2 protein of GB virus C in the study of GBV-C/HIV-1 co-infection Journal of Peptide Science. 18(5), 326-335 SUKMAWATI, A., CHAN, W. C., GARNETT, M. C. and BUTTERY, L., 2012. Biodegradable microparticles for cell aggregation and proliferation JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE. 6, 371-372 BYRNE, C., MCEWAN, P.A., EMSLEY, J., FISCHER, P.M. and CHAN, W.C., 2011. End-stapled homo and hetero collagen triple helices: a click chemistry approach Chemical Communications. 47(9), 2589-2591 WELSER, KATHARINA, ADSLEY, ROSEMARY, MOORE, BERNADETTE M., CHAN, WENG C. and AYLOTT, JONATHAN W., 2011. Protease sensing with nanoparticle based platforms Analyst. 136(1), 29-41 ABULATEEFEH, SAMER R., SPAIN, SEBASTIAN G., AYLOTT, JONATHAN W., CHAN, WENG C., GARNETT, MARTIN C. and ALEXANDER, CAMERON, 2011. Thermoresponsive polymer colloids for drug delivery and cancer therapy Macromolecular Bioscience. 11(12), 1722-1734 COOKSLEY, CLARE M, DAVIS, IAN J, WINZER, KLAUS, CHAN, WENG C and PECK, MICHAEL W. AND MINTON, NIGEL P., 2010. A putative agrBD signalling system regulates neurotoxin production and sporulation in proteolytic Clostridium botulinum. Applied and Environmental Microbiology. 76(13), 4448-4460 REZVANI, Z.N., MAYER, R.J. and CHAN, W.C., 2010. 5-Carboxyfluorescein tagged N-phenylanthranilamide as a tracer reagent for fluorescence polarization: a robust method to screen MAPK pathway allosteric inhibitors Chemical Communications. 46(12), 2043-2045 ABULATEEFEH, S.R., SAEED, A.O., AYLOTT, J.W., CHAN, W.C., GARNETT, M.C., SAUNDERS, B.R. and ALEXANDER, C., 2009. Facile synthesis of responsive nanoparticles with reversible, tuneable and rapid thermal transitions from biocompatible constituents Chemical Communications. 2009(40), 6068-6070 WELSER, K., AYAL PERERA, M.D., AYLOTT, J.W. and CHAN, W.C., 2009. A facile method to clickable sensing polymeric nanoparticles Chemical Communications. 2009(43), 6601-6603 WELSER, KATHARINA, GRILJ, JAKOB, VAUTHEY, ERIC, AYLOTT, JONATHAN W. and CHAN, WENG C., 2009. Protease responsive nanoprobes with tethered fluorogenic peptidyl 3-arylcoumarin substrates Chemical Communications. 671-673 JENSEN, R.O., WINZER, K., CLARKE, S.R., CHAN, W.C. and WILLIAMS, P., 2008. Differential recognition of Staphylococcus aureus quorum-sensing signals depends on both extracellular loops 1 and 2 of the transmembrane sensor AgrC Journal of Molecular Biology. 381(2), 300-309 PARISOT, J., CAREY, S., BREUKINK, E., CHAN, W.C., NARBAD, A. and BONEV, B., 2008. Molecular mechanism of target recognition by subtilin, a class I lanthionine antibiotic Antimicrobial Agents and Chemotherapy. 52(2), 612-618 SANNA, MONICA, WHITE, PETER D and CHAN, WENG C, 2008. A macroporous polymer-supported cyclic anhydride for efficient sequestration of amines Tetrahedron Letters. 49(42), 6160-62 MAYER, JOHN R., CHAN, WENG C. and REZVANI, ZAHRA N., 2008. MEK5 and related proteins as biomarkers of neurodegenerative diseases World Intellectual Property Organization WO 2008/132464-A2 11/01/2008 00:00:00 PARKHOUSE, SUSAN M, GARNETT, MARTIN C and CHAN, WENG C, 2008. Targeting of polyamidoamine-DNA nanoparticles using the Staudinger ligation: attachment of an RGD motif either before or after complexation. Bioorganic and Medicinal Chemistry. 16(13), 6641-50 WILLIAMS, P., WINZER, K., CHAN, W.C. and CAMARA, M., 2007. Look who's talking: communication and quorum sensing in the bacterial world Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 362, 1119-1134