Buttery, Lee - University of Nottingham

个人简介

I gained a BSc (Hons) degree in Applied Zoology at the University of Leeds in 1987 and MSc (Biomolecular Organization; 1990) and PhD (Medicine/Pathology; 1996) degrees at the University of London. Prior to moving to Nottingham in 2003, I was based largely at the former Royal Postgraduate Medical School, now part of Imperial College London working with Professor Dame Julia Polak. My PhD centred on investigating the distributions and possible functions of nitric oxide/nitric oxide synthases in the physiology and pathology of a variety of tissues and organs and I was fortunate enough to publish some of the first papers on the involvement of these molecules in human diseases, notably in the cardiovascular system. My first postdoctoral position was held jointly between Imperial College and the Royal London Hospital School of Medicine and Dentistry looking at the roles of the nitric oxide and prostaglandin pathways in bone biology and specifically the osteoblast. I returned full time to Imperial College in 1999 to take up a lectureship in cell biology and tissue engineering and was also actively involved in establishing the tissue engineering centre. From 1999 onwards my research has been focused primarily on osteoblast biology and approaches to tissue engineer and repair damaged bones. At this time I also began working with mouse and human embryonic stem cells resulting in the publication of some of the first papers describing the osteogenic differentiation of mouse ES and human cells in vitro and in vivo. In 2003 I moved to the University Nottingham and the School of Pharmacy. I am also affiliated with the Wolfson Centre for Stem Cells, Tissue Engineering and Modelling (STEM), which is also part of the Centre for Biomolecular Sciences.

研究领域

My research interests focus mainly on stem cells (embryonic, 'adult' and fetal origins) and their applications in tissue engineering, particularly the osteoblast and bone tissue.

近期论文

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MICHAEL TAYLOR, DAVID SCURR, MATTHIAS LUTOLF, LEE BUTTERY, MISCHA ZELZER and MORGAN ALEXANDER, 2016. 3D chemical characterization of frozen hydrated hydrogels using ToF-SIMS with argon cluster sputter depth profiling Biointerphases. 11(02A301), KIRKHAM GR, BRITCHFORD E, UPTON T, WARE J, GIBSON GM, DEVAUD Y, EHRBAR M, PADGETT M, ALLEN S, BUTTERY LD and SHAKESHEFF K, 2015. Precision Assembly of Complex Cellular Microenvironments using Holographic Optical Tweezers. Scientific reports. 5, 8577 TAYLOR, A. J., RATNER, B. D., BUTTERY, L. D. K. and ALEXANDER, M. R., 2015. Revealing cytokine-induced changes in the extracellular matrix with secondary ion mass spectrometry Acta Biomaterialia. 14, 70-83 SIDNEY LE, KIRKHAM GR and BUTTERY LD, 2014. Comparison of Osteogenic Differentiation of Embryonic Stem Cells and Primary Osteoblasts Revealed by Responses to IL-1β, TNF-α, and IFN-γ. Stem cells and development. 23(6), 605-17 SIDNEY LE, HEATHMAN TRJ, BRITCHFORD ER, ABED A, RAHMAN CV and BUTTERY LDK, 2014. Investigation of Localized Delivery of Diclofenac Sodium from Poly(D,L-Lactic Acid-co-Glycolic Acid)/Poly(Ethylene Glycol) Scaffolds Using an In Vitro Osteoblast Inflammation Model. Tissue engineering. Part A. (In Press.) TAYLOR AJ, RATNER BD, BUTTERY LD and ALEXANDER MR, 2014. Revealing cytokine-induced changes in the extracellular matrix with secondary ion mass spectrometry. Acta biomaterialia. 14, 70-83 EDWARD LESTER, SELINA V.Y. TANG, ANDREI KHLOBYSTOV, VANESSA LOCZENSKI ROSE, LEE BUTTERY and CLIVE J. ROBERTS, 2013. Producing nanotubes of biocompatible hydroxyapatite by continuous hydrothermal synthesis CrystEngComm. 15(17), 3256-3260 QUTACHI O, SHAKESHEFF KM and BUTTERY LDK, 2013. Delivery of definable number of drug or growth factor loaded poly(dl-lactic acid-co-glycolic acid) microparticles within human embryonic stem cell derived aggregates. Journal of controlled release : official journal of the Controlled Release Society. 168(1), 18-27 (In Press.) MORRIS, S.A., GREWAL, S., BARRIOS, F., PATANKAR, S.N., STRAUSS, B., BUTTERY, L., ALEXANDER, M., SHAKESHEFF, K.M. and ZERNICKA-GOETZ, M., 2012. Dynamics of anterior-posterior axis formation in the developing mouse embryo Nature Communications. 3, 673 ROGERS CM, WOOLLEY TS, CRUWYS SC, BUTTERY LDK, ROSE FRAJ and SHAKESHEFF KM, 2012. Engineering an in-vitro model of rodent cartilage. The journal of pharmacy and pharmacology. 64(6), 821-31 SUKMAWATI, A., CHAN, W. C., GARNETT, M. C. and BUTTERY, L., 2012. Biodegradable microparticles for cell aggregation and proliferation JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE. 6, 371-372 KIRKHAM GR, LOVRICS A, BYRNE HM, JENSEN OE, KING JR, SHAKESHEFF KM and BUTTERY LDK, 2012. Early gene regulation of osteogenesis in embryonic stem cells. Integrative biology : quantitative biosciences from nano to macro. 4(12), 1470-7 LANNIEL, M., LU, B., CHEN, Y., ALLEN, S., BUTTERY, L., WILLIAMS, P., HUQ, E. and ALEXANDER, M., 2011. Patterning the mechanical properties of hydrogen silsesquioxane films using electron beam irradiation for application in mechano cell guidance THIN SOLID FILMS. VOL 519(NUMBER 6), 2003-2010 FOZARD, J.A., KIRKHAM, G.R., BUTTERY, L.D.K., KING, J.R., JENSEN, O.E. and BYRNE, H.M., 2011. Techniques for analysing pattern formation in populations of stem cells and their progeny BMC Bioinformatics. 12, 396 PASCUT, F.C., GOH, H.T., WELCH, N., BUTTERY, L.D., DENNING, C. and NOTINGHER, I., 2011. Noninvasive detection and imaging of molecular markers in live cardiomyocytes derived from human embryonic stem cells Biophysical Journal. 100(1), 251-259 BUTTERY, L., BIELBY, R., HOWARD, HOWARD, D. and SHAKESHEFF, K., 2011. 3D Cell Culture: Methods and Protocols. In: HAYCOCK, J.W., ed., LANNIEL, M., HUQ, E., ALLEN, S., BUTTERY, L., WILLIAMS, P.M. and ALEXANDER, M.R., 2011. Substrate induced differentiation of human mesenchymal stem cells on hydrogels with modified surface chemistry and controlled modulus Soft Matter. 7(14), 6501-6514 MAHLSTEDT, M.M., ANDERSON, D., SHARP, J.S., MCGILVRAY, R., MUÑOZ, M.D., BUTTERY, L.D., ALEXANDER, M.R., ROSE, F.R.A.J. and DENNING, C., 2010. Maintenance of pluripotency in human embryonic stem cells cultured on a synthetic substrate in conditioned medium Biotechnology and Bioengineering. 105(1), 130-140 ADAMS, G.G, BUTTERY, L, STOLNIK, S, MORRIS, G.A, HARDING, S.E and WANG, N., 2010. Stem cells: the therapeutic role in the treatment of diabetes mellitus. Biotechnology and Genetic Engineering Reviews. 27, 285-304 GOTHARD, D., ROBERTS, S.J., SHAKESHEFF, K.M. and BUTTERY, L.D., 2010. Engineering embryonic stem-cell aggregation allows an enhanced osteogenic differentiation in vitro Tissue Engineering. Part C, Methods. 16(4), 583-595