Williams, Phil - University of Nottingham

个人简介

I graduated with a Bachelors of Pharmacy degree from the University of Nottingham 1988 and qualified as a Pharmacist in 1989, after which I returned to the University to undertake a PhD on "Computational Studies in Scanning Probe Microscopy" under the supervision of Martyn Davies, David Jackson and Saul Tendler. I undertook postdoctoral research in the School developing the biological applications of SPM, in particular AFM, with one focus on the analysis and compensation for tip-induced artifacts. I was appointed to a lectureship in the School in 1996. In 2000, I was awarded a five-year Advanced Research Fellowship from the Engineering and Physical Sciences Research Council during which time I was able to develop research links with Evan Evans working at the University of British Columbia in Vancouver developing the theoretical understanding of force-induced dissociation and protein unfolding experiments. I was promoted to Associate Professor and Reader in Theoretical Biophysics in 2003.

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WONG, SZU S, OSTERGAARD, SOREN, HALL, GARETH, LI, CHAN, WILLIAMS, PHILIP M, STENNICKE, HENNING and EMSLEY, JONAS, 2016. A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain. Blood. 127(23), 2915-23 TRES F, PATIENT JD, WILLIAMS PM, TREACHER K, BOOTH J, HUGHES LP, WREN SAC, AYLOTT JW and BURLEY JC, 2015. Monitoring the Dissolution Mechanisms of Amorphous Bicalutamide Solid Dispersions via Real-Time Raman Mapping. Molecular pharmaceutics. 12(5), 1512-1522 HOOK, ANDREW L., WILLIAMS, PHILIP M., ALEXANDER, MORGAN R. and SCURR, DAVID J., 2015. Multivariate ToF-SIMS image analysis of polymer microarrays and protein adsorption BIOINTERPHASES. 10(1), SANNI, OLUTOBA, CHANG, CHIEN-YI, ANDERSON, DANIEL G., LANGER, ROBERT, DAVIES, MARTYN C., WILLIAMS, PHILIP M., WILLIAMS, PAUL, ALEXANDER, MORGAN R. and HOOK, ANDREW L., 2015. Bacterial Attachment to Polymeric Materials Correlates with Molecular Flexibility and Hydrophilicity ADVANCED HEALTHCARE MATERIALS. 4(5), 695-701 PATIENT, J., HARRIS, K., ABRAHAMSSON, B., TANNERGREN, C., WHITE, L. J., GHAEMAGHAMMI, A. M., WILLIAMS, P. M., ROBERTS, C. J. and ROSE, F. R., 2015. Epithelial-Myofibroblast Co-Culture: Exploring Cross Talk at the Epithelial-Mesenchymal Barrier TISSUE ENGINEERING PART A. 21, S337-S337 SCURR, DAVID J., HOOK, ANDREW L., BURLEY, JONATHAN, WILLIAMS, PHILIP M., ANDERSON, DANIEL G., LANGER, ROBERT, DAVIES, MARTYN C. and ALEXANDER, MORGAN R., 2013. Strategies for MCR image analysis of large hyperspectral data-sets SURFACE AND INTERFACE ANALYSIS. 45(1), 466-470 BROWN A, HOROBIN A, BLOUNT DG, HILL PJ, ENGLISH J, RICH A, WILLIAMS PM and PRITCHARD DI, 2012. Blow fly Lucilia sericata nuclease digests DNA associated with wound slough/eschar and with Pseudomonas aeruginosa biofilm. Medical and Veterinary Entomology. 26(4), 432-439 BRAMPTON, C., WAHAB, O., BATCHELOR, M.R., ALLEN, S. and WILLIAMS, P.M., 2011. Biomembrane force probe investigation of RNA dissociation European Biophysics Journal. 40(3), 247-257 LANNIEL, M., LU, B., CHEN, Y., ALLEN, S., BUTTERY, L., WILLIAMS, P., HUQ, E. and ALEXANDER, M., 2011. Patterning the mechanical properties of hydrogen silsesquioxane films using electron beam irradiation for application in mechano cell guidance THIN SOLID FILMS. VOL 519(NUMBER 6), 2003-2010 LANNIEL, M., HUQ, E., ALLEN, S., BUTTERY, L., WILLIAMS, P.M. and ALEXANDER, M.R., 2011. Substrate induced differentiation of human mesenchymal stem cells on hydrogels with modified surface chemistry and controlled modulus Soft Matter. 7(14), 6501-6514 DE GRAFF, A.M.R., SHANNON, G., FARRELL, D.W., WILLIAMS, P.M. and THORPE, M.F., 2011. Protein unfolding under force: crack propagation in a network Biophysical Journal. 101(3), 736-744 BOUHROUM, ABDENNOUR, BURLEY, JONATHAN C, CHAMPNESS, NEIL R, TOON, RICHARD C, JINKS, PHILIP A, WILLIAMS, PHILIP M and ROBERTS, CLIVE J, 2010. An assessment of beclomethasone dipropionate clathrate formation in a model suspension metered dose inhaler. International Journal of Pharmaceutics. 391(1-2), 98-106 KIM, I.H., LEE, H.Y., LEE, H.D., JUNG, Y.J., TENDLER, S.J.B., WILLIAMS, P.M., ALLEN, S., RYU, S.H. and PARK, J.W., 2009. Interactions between signal transducing proteins measured by atomic force microscopy Analytical Chemistry. 81(9), 3276-3284 BOUHROUM, A, BURLEY, J, CHAMPNESS, N, TOON, R, JINKS, P, WILLIAMS, P and ROBERTS, C, 2009. Spectroscopic and structural characterisation of a beclomethasone dipropionate clathrate pre- and post-micronisation for inclusion in a pMDI formulation. In: Journal of Pharmacy and Pharmacology: BPC Science Abstracts Special Issue 61. A82-A83 TAYLOR, M, URQUHART, AJ, ANDERSON, DG, WILLIAMS, P. M and LANGER, R, ALEXANDER, MR, DAVIES, MC, 2008. A Methodology for Investigating Protein Adhesion and Adsorption to Microarrayed Combinatorial Polymers Macromolecular Rapid Communications. 29(15), 1298-1302 QAMAR, S., WILLIAMS, P.M. and LINDSAY, S.M., 2008. Can an atomic force microscope sequence DNA using a nanopore? Biophysical Journal. 94(4), 1233-1240 BORGIA, ALESSANDRO, WILLIAMS, PHILIP M and CLARKE, JANE, 2008. Single-molecule studies of protein folding. Annual review of biochemistry. 77, 101-25 YUNG, Y.J., HONG, B.J., ZHANG, W., TENDLER, S.J.B., WILLIAMS, P.M., ALLEN, S. and PARK, J.W., 2007. Dendron arrays for the force-based detection of DNA hybridization events Journal of the American Chemical Society. 129(30), 9349-9355 HILL, R.J.A., SEDMAN, V.L., ALLEN, S., WILLIAMS, P.M., PAOLI, M., ADLER-ABRAMOVICH, L., GAZIT, E, EAVES, L. and TENDLER, S.J.B., 2007. Alignment of aromatic peptide tubes in strong magnetic fields Advanced Materials. 19(24), 4474-4479 CARNALLY, STEWART, BARROW, KATHARINE, ALEXANDER, MORGAN R, HAYES, CHRISTOPHER J, STOLNIK, SNJEZANA, TENDLER, SAUL J B, WILLIAMS, PHILIP M and ROBERTS, CLIVE J, 2007. Ultra-resolution imaging of a self-assembling biomolecular system using robust carbon nanotube AFM probes. Langmuir. 23(7), 3906-11 PORTOLES, J.F., CUMPSON, P.J., HEDLEY, J., ALLEN, S., WILLIMAS, P.M. and TENDLER, S.J.B., 2006. Accurate velocity measurements of AFM-cantilever vibrations by Doppler interferometry Journal of Experimental Nanoscience. VOL 1(NUMB 1), 51-62 CLARKE, R J, JENSEN, O E, BILLINGHAM, J, PEARSON, A P and WILLIAMS, P M, 2006. Stochastic elastohydrodynamics of a microcantilever oscillating near a wall. Physical Review Letters. 96(5), 050801 TOOFANNY, RUDESH D and WILLIAMS, PHILIP M, 2006. Simulations of multi-directional forced unfolding of titin I27. Journal of molecular graphics & modelling.. 24(5), 396-403 CLARKE, R. J., JENSEN, O. E., BILLINGHAM, J. and WILLIAMS, P. M., 2006. Three-dimensional flow due to a microcantilever oscillating near a wall: an unsteady slender-body analysis Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences. VOL 462(NUMB 2067), 913-934 STEVENS, M.M., ALLEN, S., DAVIES, M.C., ROBERTS, C.J., SAKATA, J.K., TENDLER, S.J.B., TIRRELL, D.A. and WILLIAMS, P.M., 2005. Molecular level investigations of the inter- and intramolecular interactions of pH-responsive artificial triblock proteins Biomacromolecules. 6(3), 1266-1271