Shakesheff, Kevin - University of Nottingham

个人简介

I am a Pharmacist and gained my PhD from Nottingham under the supervision of Martyn Davies and Saul Tendler. In 1996 I took up a NATO Postdoctoral Fellowship at MIT with Bob Langer and returned to the UK in 1997 to take up an EPSRC Advanced Fellowship. In 2001 I was appointed to a Professorship.Major awards in recent years include: 2007 Pharmaceutical Sciences Research Achievement Award2003 Hanson Award2002 Royal Pharmaceutical Society Conference Medal. 2001 MIT Technology Review List of the World's 100 Top Young Innovators. 2000 Royal Institution Scientist for the New Century I have launched two spin-out companies, Critical Pharmaceuticals Ltd (winner of 2002 Research Councils Business Plan Competition) & RegenTec Ltd .

研究领域

My research interests focus on regenerative medicine and the delivery of biopharmaceuticals.

近期论文

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PADUANO, FRANCESCO, MARRELLI, MASSIMO, WHITE, LISA J., SHAKESHEFF, KEVIN M. and TATULLO, MARCO, 2016. Odontogenic Differentiation of Human Dental Pulp Stem Cells on Hydrogel Scaffolds Derived from Decellularized Bone Extracellular Matrix and Collagen Type I PLOS ONE. 11(2), AMER, MAHETAB H., ROSE, FELICITY R. A. J., WHITE, LISA J. and SHAKESHEFF, KEVIN M., 2016. A Detailed Assessment of Varying Ejection Rate on Delivery Efficiency of Mesenchymal Stem Cells Using Narrow-Bore Needles STEM CELLS TRANSLATIONAL MEDICINE. 5(3), 366-378 DIXON, JAMES E., OSMAN, GIZEM, MORRIS, GAVIN E., MARKIDES, HAREKLEA, ROTHERHAM, MICHAEL, BAYOUSSEF, ZAHIA, EL HAJ, ALICIA J., DENNING, CHRIS and SHAKESHEFF, KEVIN M., 2016. Highly efficient delivery of functional cargoes by the synergistic effect of GAG binding motifs and cell-penetrating peptides PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 113(3), E291-E299 BRAIM, S. A., SHAKESHEFF, K. M., SAUNDERS, B. R. and ALEXANDER, C., 2016. Thermoresponsive magnetic colloidal gels via surface-initiated polymerisation from functional microparticles JOURNAL OF MATERIALS CHEMISTRY B. 4(5), 962-972 RUIZ-CANTU, LAURA, GLEADALL, ANDREW, FARIS, CALLUM, SEGAL, JOEL, SHAKESHEFF, KEVIN and YANG, JING, 2016. Characterisation of the surface structure of 3D printed scaffolds for cell infiltration and surgical suturing BIOFABRICATION. 8(1), KIRKHAM GR, BRITCHFORD E, UPTON T, WARE J, GIBSON GM, DEVAUD Y, EHRBAR M, PADGETT M, ALLEN S, BUTTERY LD and SHAKESHEFF K, 2015. Precision Assembly of Complex Cellular Microenvironments using Holographic Optical Tweezers. Scientific reports. 5, 8577 SAWKINS, M J, MISTRY, P, BROWN, B N, SHAKESHEFF, K M, BONASSAR, L J and YANG, J, 2015. Cell and protein compatible 3D bioprinting of mechanically strong constructs for bone repair.: (one of ten highlighted papers in Biofabrication 2015) Biofabrication. 7(3), 035004 SAEED A, FRANCINI N, WHITE L, DIXON J, GOULD T, RASHIDI H, CHEIKH AL GHANAMI R, HRUSCHKA V, REDL H, SAUNDERS BR, ALEXANDER C and SHAKESHEFF KM, 2015. A Thermoresponsive and Magnetic Colloid for 3D Cell Expansion and Reconfiguration Advanced Materials. 27, 662-558 DELIVOPOULOS E, OUBERAI MM, COFFEY PD, SWANN MJ and SHAKESHEFF KM, 2015. Serum protein layers on parylene-C and silicon oxide: Effect on cell adhesion. Colloids and Surfaces B: Interfaces. 126, 169-177 SMITH EL, RASHIDI H, KANCZLER JM, SHAKESHEFF KM and OREFFO ROC, 2015. The Effects of 1?, 25-dihydroxyvitamin D3 and Transforming Growth Factor-β3 on Bone Development in an Ex Vivo Organotypic Culture System of Embryonic Chick Femora PLOS One. 10, CARLOS DEL ROSARIO, CARLOS DEL ROSARIO, MARIA RODRíGUEZ-EVORA, RICARDO REYES, ALEJANDRO GONZáLEZ-ORIVE, ALBERTO HERNáNDEZ-CREUS, KEVIN M SHAKESHEFF, LISA J WHITE, ARACELI DELGADO and CARMEN EVORA, 2015. Evaluation of nanostructure and microstructure of bone regenerated by BMP-2-porous scaffolds Journal of Biomedical Materials Research Part A. 103A, 2998-3011 BRAIM SA, SHAKESHEFF KM and SAUNDERS BR, 2015. Thermoresponsive magnetic colloidal gels via surface-initiated polymerisation from functional microparticles Journal of Materials Chemistry B. 4, 962-972 GOTHARD, DAVID, SMITH, EMMA L., KANCZLER, JANOS M., BLACK, CAMERON R., WELLS, JULIA A., ROBERTS, CAROL A., WHITE, LISA J., QUTACHI, OMAR, PETO, HEATHER, RASHIDI, HASSAN, ROJO, LUIS, STEVENS, MOLLY M., EL HAJ, ALICIA J., ROSE, FELICITY R. A. J., SHAKESHEFF, KEVIN M. and OREFFO, RICHARD O. C., 2015. In Vivo Assessment of Bone Regeneration in Alginate/Bone ECM Hydrogels with Incorporated Skeletal Stem Cells and Single Growth Factors PLOS ONE. 10(12), DIXON JAMES E, OSMAN GIZEM, MORRIS GAVIN E, MARKIDES HAREKLEA, ROTHERHAM MICHAEL, BAYOUSSEF ZAHIA, EL HAJ ALICIA J., DENNING CHRIS and SHAKESHEFF KEVIN M, 2015. Highly efficient delivery of functional cargoes by the synergistic effect of GAG binding motifs and cell-penetrating peptides PNAS. 113, E291-E299 TATULLO, MARCO, MARRELLI, MASSIMO, SHAKESHEFF, KEVIN M. and WHITE, LISA J., 2015. Dental pulp stem cells: function, isolation and applications in regenerative medicine JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE. 9(11), 1205-1216 GOULD, TOBY W., SMITH, STUART J., RAHMAN, CHERYL V., BARRETT, DAVID A., SHAKESHEFF, KEVIN M., GRUNDY, RICHARD G. and RAHMAN, RUMAN, 2015. SIMULTANEOUS INTRA-CAVITY DELIVERY OF MULTIPLE CHEMOTHERAPEUTICS FROM A MOULDABLE NEUROSURGICALLY-APPLIED POLYMER PASTE NEURO-ONCOLOGY. 17, 20-20 HRUSCHKA, VERONIKA, SAEED, ARAM, SLEZAK, PAUL, AL GHANAMI, RACHA CHEIKH, FEICHTINGER, GEORG ALEXANDER, ALEXANDER, CAMERON, REDL, HEINZ, SHAKESHEFF, KEVIN and WOLBANK, SUSANNE, 2015. Evaluation of a Thermoresponsive Polycaprolactone Scaffold for In Vitro Three-Dimensional Stem Cell Differentiation Tissue Engineering Part A. 21(1-2), 310-319 DELIVOPOULOS, EVANGELOS, SHAKESHEFF, KEVIN M and PETO, HEATHER, 2015. Neuralization of mouse embryonic stem cells in alginate hydrogels under retinoic acid and SAG treatment. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. 2015, 3525-8 OTHMAN, REBEEN, MORRIS, GAVIN E., SHAH, DISHEET A., HALL, STEPHEN, HALL, GRAHAM, WELLS, KEITH, SHAKESHEFF, KEVIN M. and DIXON, JAMES E., 2015. An automated fabrication strategy to create patterned tubular architectures at cell and tissue scales BIOFABRICATION. 7(2), RAHMAN, CHERYL V., BEN-DAVID, DROR, DHILLON, AMRITPAUL, KUHN, GISELA, GOULD, TOBY W. A., MUELLER, RALPH, ROSE, FELICITY R. A. J., SHAKESHEFF, KEVIN M. and LIVNE, ERELLA, 2014. Controlled release of BMP-2 from a sintered polymer scaffold enhances bone repair in a mouse calvarial defect model JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE. 8(1), 59-66 REINWALD, Y., JOHAL, R. K., GHAEMMAGHAMI, A. M., ROSE, F. R. A. J., HOWDLE, S. M. and SHAKESHEFF, K. M., 2014. Interconnectivity and permeability of supercritical fluid-foamed scaffolds and the effect of their structural properties on cell distribution POLYMER. 55(1), 435-444 SMITH, S. J., RAHMAN, C. V., CLARKE, P. A., RITCHIE, A. A., GOULD, T. T., WARD, J. H., SHAKESHEFF, K. M., GRUNDY, R. G. and RAHMAN, R., 2014. Surgical delivery of drug releasing poly(lactic-co-glycolic acid)/poly(ethylene glycol) paste with in vivo effects against glioblastoma ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND. 96(7), 495-501 QUTACHI, OMAR, VETSCH, JOLANDA R., GILL, DANIEL, COX, HELEN, SCURR, DAVID J., HOFMANN, SANDRA, MUELLER, RALPH, QUIRK, ROBIN A., SHAKESHEFF, KEVIN M. and RAHMAN, CHERYL V., 2014. Injectable and porous PLGA microspheres that form highly porous scaffolds at body temperature ACTA BIOMATERIALIA. 10(12), 5090-5098 SMITH, E. L., KANCZLER, J. M., GOTHARD, D., ROBERTS, C. A., WELLS, J. A., WHITE, L. J., QUTACHI, O., SAWKINS, M. J., PETO, H., RASHIDI, H., ROJO, L., STEVENS, M. M., EL HAJ, A. J., ROSE, F. R. A. J., SHAKESHEFF, K. M. and OREFFO, R. O. C., 2014. Evaluation of skeletal tissue repair, Part 1: Assessment of novel growth-factor-releasing hydrogels in an ex vivo chick femur defect model ACTA BIOMATERIALIA. 10(10), 4186-4196 SMITH, E. L., KANCZLER, J. M., GOTHARD, D., ROBERTS, C. A., WELLS, J. A., WHITE, L. J., QUTACHI, O., SAWKINS, M. J., PETO, H., RASHIDI, H., ROJO, L., STEVENS, M. M., EL HAJ, A. J., ROSE, F. R. A. J., SHAKESHEFF, K. M. and OREFFO, R. O. C., 2014. Evaluation of skeletal tissue repair, Part 2: Enhancement of skeletal tissue repair through dual-growth-factor-releasing hydrogels within an ex vivo chick femur defect model ACTA BIOMATERIALIA. 10(10), 4197-4205