Pritchard, David - University of Nottingham

个人简介

I graduated from the University of Wales in 1973 with a BSc in Zoology. This was followed with an MSc in Immunology at the University of Birmingham in 1974 and I completed my PhD in Immunology in 1977. In 1977 I joined AstraZeneca, Loughborough, as an Industrial Research Scientist. In 1981 I joined the University of Nottingham as a MRC Postdoctoral Researcher, was promoted to Lecturer in Immunology, School of Biological Sciences, in 1983 and Reader in Immunology in 1991. In 1996 I was awarded a Wellcome Research Leave Fellowship which I undertook at the University of Leicester's Centre for Mechanisms of Human Toxicity. I joined the School of Pharmacy in 1998 as Chair in Parasite Immunology.

研究领域

I am interested in the way a variety of organisms interact with the human body.

近期论文

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WILSON, M. R., NIGAM, Y., JUNG, W., KNIGHT, J. and PRITCHARD, D. I., 2016. The impacts of larval density and protease inhibition on feeding in medicinal larvae of the greenbottle fly Lucilia sericata MEDICAL AND VETERINARY ENTOMOLOGY. 30(1), 1-7 DAVID I PRITCHARD, VáCLAV ?E?OVSKY, YAMNI NIGAM, SAMANTHA F PICKLES, GWENDOLYN CAZANDER, PETER H NIBBERING, ANKE BüLTEMANN and WILHELM JUNG, 2016. TIME management by medicinal larvae International Wound Journal. 13(4), 475-484 PRITCHARD DI and BROWN AP, 2015. Degradation of MSCRAMM target macromolecules in VLU slough by Lucilia sericata chymotrypsin 1 (ISP) persists in the presence of tissue gelatinase activity. International Wound Journal. 414-421 HUTTER V, CHAU DY, HILGENDORF C, BROWN A, COOPER A, ZANN V, PRITCHARD DI, BOSQUILLON C., CHAU DY,, HILGENDORF C,, BROWN A,, COOPER A,, ZANN V,, PRITCHARD DI, and BOSQUILLON C., 2014. Digoxin net secretory transport in bronchial epithelial cell layers is not exclusively mediated by P-glycoprotein/MDR1. European Journal of Pharmaceutics and Biopharmaceutics. 86(1), 74-82 KHAN ADNAN R, MAGNUSSON JOHANNES PALL, WATSON SUE, GRABOWSKA ANNA M, WILKINSON ROBERT W, ALEXANDER CAMERON and PRITCHARD DAVID, 2014. Camptothecin prodrug block copolymer micelles with high drug loading and target specificity Polymer Chemistry. 5(18), 5320-5329 HARRIS, L.G., NIGAM, Y., SAWYER, J., MACK, D. and PRITCHARD, D.I., 2013. Lucilia sericata Chymotrypsin Disrupts Protein Adhesin-Mediated Staphylococcal Biofilm Formation Applied and Environmental Microbiology. 79(4), 1393-1395 MUKHERJEE, M., LATIF, M.L., PRITCHARD, D.I. and BOSQUILLON, C., 2013. In-cell Western? detection of organic cation transporters in bronchial epithelial cell layers cultured at an air-liquid interface on Transwell? inserts. J Pharmacol Toxicol Methods. 68(2), 184-189 BAYARD, F.J.C., THIELEMANS, W., PRITCHARD, D.I., PAINE, S.W., YOUNG, S.S., B?CKMAN, P., EWING, P. and BOSQUILLON, C., 2013. Polyethylene glycol-drug ester conjugates for prolonged retention of small inhaled drugs in the lung Journal of Controlled Release. 171(2), 234-240 CHAUHAN, V.M., ORSI, G., BROWN, A., PRITCHARD, D.I. and AYLOTT, J.W., 2013. Mapping the pharyngeal and intestinal pH of Caenorhabditis elegans and real-time luminal pH oscillations using extended dynamic range pH-sensitive nanosensors ACS Nano. 7(6), 5577-5587 ANGELL HK, GRAY N, WOMACK C, PRITCHARD DI, WILKINSON RW and CUMBERBATCH M, 2013. Digital pattern recognition-based image analysis quantifies immune infiltrates in distinct tissue regions of colorectal cancer and identifies a metastatic phenotype. British Journal of Cancer. 109, 1618-1624 DAVID E. ELLIOTT, DAVID I. PRITCHARD and JOEL V. WEINSTOCK, 2013. Helminth Therapy. In: MARTIN GRASSBERGER, RONALD A. SHERMAN, OLGA S. GILEVA, CHRISTOPHER M.H. KIM and KOSTA Y. MUMCUOGLU, eds., Biotherapy - History, Principles and Practice: A Practical Guide to the Diagnosis and Treatment of Disease using Living Organisms 1. Springer. 177-190 LUI LT, XUE X, SUI C, BROWN A, PRITCHARD DI, HALLIDAY N, WINZER K, HOWDLE SM, FERNANDEZ-TRILLO F, KRASNOGOR N and ALEXANDER C, 2013. Bacteria clustering by polymers induces the expression of quorum-sensing-controlled phenotypes. Nature Chemistry. 5(12), 1058-65 PRITCHARD DI and NIGAM Y, 2013. Maximising the secondary beneficial effects of larval debridement therapy. Journal of Wound Care. 22(11), 610-11, 614-6 CAZANDER G, PRITCHARD DI, NIGAM Y, JUNG W and NIBBERING PH, 2013. Multiple actions of Lucilia sericata larvae in hard-to-heal wounds: larval secretions contain molecules that accelerate wound healing, reduce chronic inflammation and inhibit bacterial infection. BioEssays : news and reviews in molecular, cellular and developmental biology. 35(12), 1083-92 BROWN A, HOROBIN A, BLOUNT DG, HILL PJ, ENGLISH J, RICH A, WILLIAMS PM and PRITCHARD DI, 2012. Blow fly Lucilia sericata nuclease digests DNA associated with wound slough/eschar and with Pseudomonas aeruginosa biofilm. Medical and Veterinary Entomology. 26(4), 432-439 TELFORD G, BROWN AP, RICH A, ENGLISH JSC and PRITCHARD DI, 2012. The wound debridement potential of maggot (Lucilia sericata) glycosidases. Medical and Veterinary Entomology. 26, 291-299 MUKHERJEE M, PRITCHARD DI and BOSQUILLON C, 2012. Evaluation Of Air-Interfaced Calu-3 Cell Layers For Investigation Of Inhaled Drug Interactions With Organic Cation Transporters In Vitro. International Journal Of Pharmaceutics. 426(1-2), 7-14 PRITCHARD DI, TELFORD G, DIAB M and LOW W, 2012. Expression Of A c Gmp Compatible Lucilia Sericata Insect Serine Proteinase (ISP) Debridement Enzyme. Biotechnology Progress. 28(2), 567-72 PRITCHARD DI, BLOUNT DG, SCHMID-GRENDELMEIER P and TILL SJ, 2012. Parasitic Worm Therapy For Allergy: Is This Incongruous Or Avant-Garde Medicine? Clinical And Experimental Allergy : Journal Of The British Society For Allergy And Clinical Immunology. 42(4), 505-512 HUTTER V, HILGENDORF C, COOPER A, ZANN V, PRITCHARD DI and BOSQUILLON C, 2012. Evaluation of layers of the rat airway epithelial cell line rl-65 for permeability screening of inhaled drug candidates. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. 47(2), 481-9 DAVID I. PRITCHARD, 2012. Worm therapy: How would you like your medicine? International Journal for Parasitology: Drugs and Drug Resistance. 2, 106-108 TELFORD, G., BROWN, A.P., KIND, A., ENGLISH, J.S.C. and PRITCHARD, D.I., 2011. Maggot chymotrypsin I from Lucilia sericata is resistant to endogenous wound protease inhibitors British Journal of Dermatology. 164(1), 192-196 GAISFORD W, PRITCHARD DI and COOKE A, 2011. OdDHL inhibits T Cell subset differentiation and delays diabetes onset in NOD mice. Clinical And Vaccine Immunology. 18(8), 1213-20 PRITCHARD DI, 2011. Invited Review: Worm Therapy: For or Against? J Helminthology. 85(3), 225-227 BRITLAND ST, SMITH AG, FINTER WF, VOWDEN K, VOWDEN P, TELFORD G, BROWN A, PRITCHARD DI and EAGLAND D, 2011. Recombinant Lucilia Sericata Chymotrypsin in a Tropical Hydrogel Formulation Degrades Human Wound Eschar Ex Vivo Biotechnology Progress. 27(3), 870-874