Kellam, Barrie - University of Nottingham

个人简介

I am a Pharmacist and gained my PhD from the School of Pharmacy at the University of Nottingham under the supervision of Prof Barrie Bycroft. After an eighteen month postdoctoral position at the School of Pharmacy, London under the mentorship of Prof Istvan Toth I was appointed to a lectureship at Nottingham in 1997. I was promoted to Associate Professor in 2006.

近期论文

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DISNEY AJ, KELLAM B and DEKKER LV, 2016. Alkylation of Staurosporine to Derive a Kinase Probe for Fluorescence Applications. ChemMedChem. 11(9), 972-9 DISNEY, ALEXANDER J M, KELLAM, BARRIE and DEKKER, LODEWIJK V, 2016. Alkylation of Staurosporine to Derive a Kinase Probe for Fluorescence Applications: ChemMedChem ChemMedChem. 11(9), 972-979 STODDART, LEIGH A., VERNALL, ANDREA J., BRIDDON, STEPHEN J., KELLAM, BARRIE and HILL, STEPHEN J., 2015. Direct visualisation of internalization of the adenosine A(3) receptor and localization with arrestin3 using a fluorescent agonist NEUROPHARMACOLOGY. 98, 68-77 SCHWEHM, CAROLIN, LI, JIN, SONG, HONGMEI, HU, XIAO, KELLAM, BARRIE and STOCKS, MICHAEL J., 2015. Synthesis of New DPP-4 Inhibitors Based on a Novel Tricyclic Scaffold: ACS Medicinal Chemistry Letters ACS Medicinal Chemistry Letters. 6, 324-328 STONE, ERICA L., CITOSSI, FRANCESCA, SINGH, RAJINDER, KAUR, BALVINDER, GASKELL, MARGARET, FARMER, PETER B., MONKS, ANNE, HOSE, CURTIS, STEVENS, MALCOLM F. G., LEONG, CHEE-ONN, STOCKS, MICHAEL, KELLAM, BARRIE, MARLOW, MARIA and BRADSHAW, TRACEY D., 2015. Antitumour benzothiazoles. Part 32: DNA adducts and double strand breaks correlate with activity; synthesis of 5F203 hydrogels for local delivery BIOORGANIC & MEDICINAL CHEMISTRY. 23(21), 6891-6899 SCHEMBRI, LUKE S., STODDART, LEIGH A., BRIDDON, STEPHEN J., KELLAM, BARRIE, CANALS, MERITXELL, GRAHAM, BIM and SCAMMELLS, PETER J., 2015. Synthesis, Biological Evaluation, and Utility of Fluorescent Ligands Targeting the mu-Opioid Receptor JOURNAL OF MEDICINAL CHEMISTRY. 58(24), 9754-9767 SCHWEHM, CAROLIN, LI, JIN, SONG, HONGMEI, HU, XIAO, KELLAM, BARRIE and STOCKS, MICHAEL J, 2015. Synthesis of New DPP-4 Inhibitors Based on a Novel Tricyclic Scaffold.: Acs Medicinal Chemistry Letters Acs Medicinal Chemistry Letters. 6(3), 324-328 STONE, ERICA L, CITOSSI, FRANCESCA, SINGH, RAJINDER, KAUR, BALVINDER, GASKELL, MARGARET, FARMER, PETER B, MONKS, ANNE, HOSE, CURTIS, STEVENS, MALCOLM F G, LEONG, CHEE-ONN, STOCKS, MICHAEL, KELLAM, BARRIE, MARLOW, MARIA and BRADSHAW, TRACEY D, 2015. Antitumour benzothiazoles. Part 32: DNA adducts and double strand breaks correlate with activity; synthesis of 5F203 hydrogels for local delivery.: Bioorganic & medicinal chemistry Bioorganic & medicinal chemistry. 23(21), 6891-6899 STODDART, LEIGH A, VERNALL, ANDREA J., BRIDDON, STEPHEN J, KELLAM, BARRIE and HILL, STEPHEN J, 2015. Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist.: Neuropharmacology Neuropharmacology. 98, 68-77 SCHEMBRI, LUKE S, STODDART, LEIGH A, BRIDDON, STEPHEN J, KELLAM, BARRIE, CANALS, MERITXELL, GRAHAM, BIM and SCAMMELLS, PETER J, 2015. Synthesis, Biological Evaluation, and Utility of Fluorescent Ligands Targeting the μ-Opioid Receptor.: Journal of Medicinal Chemistry Journal of Medicinal Chemistry. 58(24), 9754-9767 VERNALL, ANDREA J., HILL, STEPHEN J. and KELLAM, BARRIE, 2014. The evolving small-molecule fluorescent-conjugate toolbox for Class A GPCRs BRITISH JOURNAL OF PHARMACOLOGY. 171(5), 1073-1084 STODDART, LEIGH A., KELLAM, BARRIE, BRIDDON, STEPHEN J. and HILL, STEPHEN J., 2014. Effect of a toggle switch mutation in TM6 of the human adenosine A(3) receptor on Gi protein-dependent signalling and Gi-independent receptor internalization BRITISH JOURNAL OF PHARMACOLOGY. 171(16), 3827-3844 HILL, STEPHEN J., MAY, LAUREN T., KELLAM, BARRIE and WOOLARD, JEANETTE, 2014. Allosteric interactions at adenosine A(1) and A(3) receptors: new insights into the role of small molecules and receptor dimerization BRITISH JOURNAL OF PHARMACOLOGY. 171(5), 1102-1113 CORRIDEN R, KILPATRICK LE, KELLAM B, BRIDDON SJ and HILL SJ, 2014. Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism. FASEB journal. 28, 4211-4222 SKILLING, K. J., NDUNGU, A., KELLAM, B., ASHFORD, M., BRADSHAW, T. D. and MARLOW, M., 2014. Gelation properties of self-assembling N-acyl modified cytidine derivatives JOURNAL OF MATERIALS CHEMISTRY B. 2(47), 8412-8417 SCHWEHM, CAROLIN, LEWIS, WILLIAM, BLAKE, ALEXANDER J., KELLAM, BARRIE and STOCKS, MICHAEL J., 2014. Preparation and structural analysis of (±)- cis -ethyl 2-sulfanylidenedecahydro-1,6-naphthyridine-6-carboxylate and (±)- trans -ethyl 2-oxooctahydro-1 H -pyrrolo[3,2- c ]pyridine-5-carboxylate: Acta Crystallographica Section C Structural Chemistry Acta Crystallographica Section C Structural Chemistry. 70, 1161-1168 SKILLING, K J, NDUNGU, A, KELLAM, BARRIE, ASHFORD, M, BRADSHAW, T D and MARLOW, M, 2014. Gelation properties of self-assembling N-acyl modified cytidine derivatives: J. Mater. Chem. B J. Mater. Chem. B. 2(47), 8412-8417 HILL, STEPHEN J, MAY, LAUREN T, KELLAM, BARRIE and WOOLARD, JEANETTE, 2014. Allosteric interactions at adenosine A1 and A3 receptors: new insights into the role of small molecules and receptor dimerization: British journal of pharmacology British journal of pharmacology. 171(5), 1102-1113 VERNALL, ANDREA J., HILL, STEPHEN J and KELLAM, BARRIE, 2014. The evolving small-molecule fluorescent-conjugate toolbox for Class A GPCRs: British journal of pharmacology British journal of pharmacology. 171(5), 1073-1084 SKILLING, KATHRYN J, CITOSSI, FRANCESCA, BRADSHAW, TRACEY D, ASHFORD, MARIANNE, KELLAM, BARRIE and MARLOW, MARIA, 2014. Insights into low molecular mass organic gelators: a focus on drug delivery and tissue engineering applications.: Soft Matter Soft Matter. 10(2), 237-256 STODDART, LEIGH A, KELLAM, BARRIE, BRIDDON, STEPHEN J and HILL, STEPHEN J, 2014. Effect of a toggle switch mutation in TM6 of the human adenosine A3 receptor on Gi protein-dependent signalling and Gi-independent receptor internalization.: British journal of pharmacology British journal of pharmacology. 171(16), 3827-3844 SCHWEHM, CAROLIN, LEWIS, WILLIAM, BLAKE, ALEXANDER J, KELLAM, BARRIE and STOCKS, MICHAEL J, 2014. Preparation and structural analysis of (±)-cis-ethyl 2-sulfanylidenedecahydro-1,6-naphthyridine-6-carboxylate and (±)-trans-ethyl 2-oxooctahydro-1H-pyrrolo[3,2-c]pyridine-5-carboxylate.: Acta crystallographica. Section C, Structural chemistry Acta crystallographica. Section C, Structural chemistry. 70(Pt 12), 1161-1168 CORRIDEN, R., SELF, T., AKONG-MOORE, K., NIZET, V., KELLAM, B., BRIDDON, S.J. and HILL, S.J., 2013. Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes EMBO Reports. 14(8), 726-732 MISTRY, S.N., BAKER, J.G., FISCHER, P.M., HILL, S.J., GARDINER, S.M. and KELLAM, B., 2013. Synthesis and in vitro and in vivo characterization of highly β1-selective β-adrenoceptor partial agonists Journal of Medicinal Chemistry. 56(10), 3852-3865 VERNALL AJ, STODDART LA, BRIDDON SJ, NG HW, LAUGHTON CA, DOUGHTY SW, HILL SJ and KELLAM B, 2013. Conversion of a non-selective adenosine receptor antagonist into A3-selective high affinity fluorescent probes using peptide-based linkers. Organic & biomolecular chemistry. 11(34), 5673-82