Fischer, Peter - University of Nottingham

个人简介

I gained my first degree and PhD in organic and medicinal chemistry under the supervision of Merlin EH Howden in Australia (Macquarie and Deakin Universities). After a short stint in a lectureship at Deakin University I entered into the biotechnology sector with a university drug discovery spin-out company in 1990. I later moved to Norway, where I helped Nycomed (now part of GE Healthcare), a world-leading diagnostics company, establish a medicinal chemistry unit as part of a new therapeutics division. In 1997 I joined Sir David Lane at Cyclacel (then a Dundee-based start-up and now a public biopharmaceuticals company) to established chemistry and drug design capabilities, and subsequently led the discovery research activities at Cyclacel for almost eight years. Cancer drug candidates that we discovered during that period are currently under clinical investigation. After a 15-year career in drug discovery and medicinal chemistry research and development in the pharmaceutical and biotechnology industry, I took the Chair in Medicinal Chemistry in the School of Pharmacy at the University of Nottingham in mid-2005.

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NURZY?SKA, KATARZYNA, AUSTIN, RUPERT P., FISCHER, PETER M., BOOTH, JONATHAN and GOMMER, FRANK, 2016. Survival of the Fittest: Time-To-Event Modeling of Crystallization of Amorphous Poorly Soluble Drugs: Journal of Pharmaceutical Sciences Journal of Pharmaceutical Sciences. 105(6), 1858-1866 EMTAGE, ABIGAIL L., MISTRY, SHAILESH N., FISCHER, PETER M., KELLAM, BARRIE and LAUGHTON, CHARLES A., 2016. GPCRs through the keyhole: the role of protein flexibility in ligand binding to β-adrenoceptors. Journal of biomolecular structure & dynamics. 1-16 (In Press.) SOUKARIEH, FADI, NOWICKI, MATTHEW W., BASTIDE, AMANDINE, POYRY, TUIJA, JONES, CAROLYN, DUDEK, KATE, PATWARDHAN, GEETANJALI, MEULLENET, FRANCOIS, OLDHAM, NEIL J., WALKINSHAW, MALCOLM D., WILLIS, ANNE E. and FISCHER, PETER M., 2016. Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation. European journal of medicinal chemistry. 124, 200-217 ZGAIR, ATHEER, WONG, JONATHAN CM, LEE, JONG BONG, MISTRY, JATIN, SIVAK, OLENA, WASAN, KISHOR M, HENNIG, IVO M, BARRETT, DAVID A, CONSTANTINESCU, CRIS S, FISCHER, PETER M and GERSHKOVICH, PAVEL, 2016. Dietary fats and pharmaceutical lipid excipients increase systemic exposure to orally administered cannabis and cannabis-based medicines. American journal of translational research. 8(8), 3448-59 FRIDGEIRSDOTTIR GA, HARRIS R, FISCHER PM and ROBERTS CJ, 2016. Support Tools in Formulation Development for Poorly Soluble Drugs. Journal of Pharmaceutical Sciences. 105(8), 2260-9 FISCHER, PETER M., 2016. Approved and Experimental Small-Molecule Oncology Kinase Inhibitor Drugs: A Mid-2016 Overview Medicinal Research Reviews. (In Press.) PATHAK M, WILMANN P, AWFORD J, LI C, HAMAD BK, FISCHER PM, DREVENY I, DEKKER LV and EMSLEY J, 2015. Coagulation factor XII protease domain crystal structure. Journal of thrombosis and haemostasis : JTH. 13(4), 580-591 HALLIDAY, M., RADFORD, H., SEKINE, Y., MORENO, J., VERITY, N., LE QUESNE, J., ORTORI, C. A., BARRETT, D. A., FROMONT, C., FISCHER, P. M., HARDING, H. P., RON, D. and MALLUCCI, G. R., 2015. Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity CELL DEATH & DISEASE. 6, JADHAV, GOPAL P., KAUR, ISHWINDER, MARYATI, MARYATI, AIRHIHEN, BLESSING, FISCHER, PETER M. and WINKLER, G. SEBASTIAAN, 2015. Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1: Bioorganic & Medicinal Chemistry Letters Bioorganic & Medicinal Chemistry Letters. 25(19), 4219-4224 ZGAIR, ATHEER, WONG, JONATHAN C. M., SABRI, AKMAL, FISCHER, PETER M., BARRETT, DAVID A., CONSTANTINESCU, CRIS S. and GERSHKOVICH, PAVEL, 2015. Development of a simple and sensitive HPLC–UV method for the simultaneous determination of cannabidiol and Δ9-tetrahydrocannabinol in rat plasma: Journal of Pharmaceutical and Biomedical Analysis J. Pharm. Biomed. Anal.. 114(0), 145-151 SEKINE, Y., ZYRYANOVA, A., CRESPILLO-CASADO, A., FISCHER, P. M., HARDING, H. P. and RON, D., 2015. Mutations in a translation initiation factor identify the target of a memory-enhancing compound: Science Science. 348(6238), 1027-1030 NURZY?SKA, KATARZYNA, BOOTH, JONATHAN, ROBERTS, CLIVE J., MCCABE, JAMES, DRYDEN, IAN and FISCHER, PETER M., 2015. Long-Term Amorphous Drug Stability Predictions Using Easily Calculated, Predicted, and Measured Parameters: Molecular Pharmaceutics Molecular Pharmaceutics. 12(9), 3389-3398 CHEN, C.-H., GENAPATHY, S., FISCHER, P.M. and CHAN, W.C., 2014. A facile approach to tryptophan derivatives for the total synthesis of argyrin analogues Organic and Biomolecular Chemistry. 12(48), 9764-9768 LAM, F., ABBAS, A. Y., SHAO, H., TEO, T., ADAMS, J., LI, P., BRADSHAW, T. D., FISCHER, P. M., WALSBY, E., PEPPER, C., CHEN, Y., DING, J. and WANG, S., 2014. Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73: Oncotarget Oncotarget. 5(17), 7691-704 REDDY, T. R., LI, C., GUO, X., FISCHER, P. M. and DEKKER, L. V., 2014. Design, synthesis and SAR exploration of tri-substituted 1,2,4-triazoles as inhibitors of the annexin A2-S100A10 protein interaction: Bioorg Med Chem Bioorg Med Chem. 22(19), 5378-91 MAZANETZ, M. P., LAUGHTON, C. A. and FISCHER, P. M., 2014. Investigation of the flexibility of protein kinases implicated in the pathology of Alzheimer's disease: Molecules Molecules. 19(7), 9134-59 MARYATI, M., KAUR, I., JADHAV, G. P., OLOTU-UMOREN, L., OVEH, B., HASHMI, L., FISCHER, P. M. and WINKLER, G. S., 2014. A fluorescence-based assay suitable for quantitative analysis of deadenylase enzyme activity: Nucleic Acids Res Nucleic Acids Res. 42(5), e30 WALSBY, ELISABETH, PRATT, GUY, SHAO, HAO, ABBAS, ABDULLAH Y., FISCHER, PETER M., BRADSHAW, TRACEY D., BRENNAN, PAUL, FEGAN, CHRIS, WANG, SHUDONG and PEPPER, CHRIS, 2014. A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine: Oncotarget Oncotarget. 5, 375-385 SHAO, HAO, SHI, SHENHUA, HUANG, SHILIANG, HOLE, ALISON, ABBAS, ABDULLAHI Y., BAUMLI, SONJA, LIU, XIANGRUI, LAM, FRANKIE, FOLEY, DAVID W., FISCHER, PETER M., NOBLE, MARTIN, ENDICOTT, JANE A., PEPPER, CHRIS and WANG, SHUDONG, 2013. Substituted 4-(thiazol-5-yl)-2-(phenylamino)pyrimidines are highly active CDK9 inhibitors: synthesis, x-ray crystal structure, SAR and anti-cancer activities: Journal of Medicinal Chemistry Journal of Medicinal Chemistry. 56, 640-659 MISTRY, S.N., BAKER, J.G., FISCHER, P.M., HILL, S.J., GARDINER, S.M. and KELLAM, B., 2013. Synthesis and in vitro and in vivo characterization of highly β1-selective β-adrenoceptor partial agonists Journal of Medicinal Chemistry. 56(10), 3852-3865 MORENO, J.A., HALLIDAY, M., MOLLOY, C., RADFORD, H., VERITY, N., AXTEN, J.M., ORTORI, C.A., WILLIS, A.E., FISCHER, P.M., BARRETT, D.A. and MALLUCCI, G.R., 2013. Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice: Science Translational Medicine Science Translational Medicine. 5(206), 206ra138 MARYATI M, KAUR I, JADHAV GP, OLOTU-UMOREN L, OVEH B, HASHMI L, FISCHER PM and WINKLER GS, 2013. A fluorescence-based assay suitable for quantitative analysis of deadenylase enzyme activity. Nucleic acids research. (In Press.) SHAO H, SHI S, FOLEY DW, LAM F, ABBAS AY, LIU X, HUANG S, JIANG X, BAHARIN N, FISCHER PM and WANG S, 2013. Synthesis, structure-activity relationship and biological evaluation of 2,4,5-trisubstituted pyrimidine CDK inhibitors as potential anti-tumour agents. European journal of medicinal chemistry. 70, 447-55 DICKENS MP, ROXBURGH P, HOCK A, MEZNA M, KELLAM B, VOUSDEN KH and FISCHER PM, 2013. 5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2. Bioorganic & medicinal chemistry. 21(22), 6868-77 LIU, XIANGRUI, LAM, FRANKIE, SHI, SHENHUA, FISCHER, PETER M and WANG, SHUDONG, 2012. In vitro antitumor mechanism of a novel cyclin-dependent kinase inhibitor CDKI-83. Investigational new drugs. 30(3), 889-897