Wahl, Christian - Ludwig-Maximilians-Universität München

个人简介

Studied medicine at the Universities of Freiburg and Heidelberg 1997 Ph.D., Freiburg 1999-2000 scientific assistant at the Klinikum Gro?hadern, LMU Munich 2000-2007 scientific assistant, LMU Munich 2007 Habilitation, LMU Munich Since 2007 Profes

研究领域

Functional analysis of voltage-gated calcium channels Functional analysis of pacemaker channels

近期论文

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Impact of Hyperpolarization-activated, Cyclic Nucleotide-gated Cation Channel Type 2 for the Xenon-mediated Anesthetic Effect: Evidence from In Vitro and In Vivo Experiments. Mattusch C, Kratzer S, Buerge M, Kreuzer M, Engel T, Kopp C, Biel M, Hammelmann V, Ying SW, Goldstein PA, Kochs E, Haseneder R, Rammes G. Anesthesiology. 2015 Mar 17. [Epub ahead of print]. PMID: 25782754. Select item 25722412 Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment. Sakurai Y, Kolokoltsov AA, Chen CC, Tidwell MW, Bauta WE, Klugbauer N, Grimm C, Wahl-Schott C, Biel M, Davey RA. Science. 2015 Feb 27;347(6225):995-8. doi: 10.1126/science.1258758. PMID: 25722412. Select item 25615882 Retinal gene delivery by adeno-associated virus (AAV) vectors: Strategies and applications. Schön C, Biel M, Michalakis S. Eur J Pharm Biopharm. 2015 Jan 20. pii: S0939-6411(15)00012-0. doi: 10.1016/j.ejpb.2015.01.009. [Epub ahead of print]. PMID: 25615882. Select item 25476906 DNA methylation and differential gene regulation in photoreceptor cell death. Farinelli P, Perera A, Arango-Gonzalez B, Trifunovic D, Wagner M, Carell T, Biel M, Zrenner E, Michalakis S, Paquet-Durand F, Ekström PA. Cell Death Dis. 2014 Dec 4;5:e1558. doi: 10.1038/cddis.2014.512. PMID: 25476906. Select item 25344628 Rods in daylight act as relay cells for cone-driven horizontal cell-mediated surround inhibition. Szikra T, Trenholm S, Drinnenberg A, Jüttner J, Raics Z, Farrow K, Biel M, Awatramani G, Clark DA, Sahel JA, da Silveira RA, Roska B. Nat Neurosci. 2014 Dec;17(12):1728-35. doi: 10.1038/nn.3852. Epub 2014 Oct 26. PMID: 25344628. Select item 25144390 High susceptibility to fatty liver disease in two-pore channel 2-deficient mice. Grimm C, Holdt LM, Chen CC, Hassan S, Müller C, Jörs S, Cuny H, Kissing S, Schröder B, Butz E, Northoff B, Castonguay J, Luber CA, Moser M, Spahn S, Lüllmann-Rauch R, Fendel C, Klugbauer N, Griesbeck O, Haas A, Mann M, Bracher F, Teupser D, Saftig P, Biel M, Wahl-Schott C. Nat Commun. 2014 Aug 21;5:4699. doi: 10.1038/ncomms5699. PMID: 25144390. Select item 25130899 Cellular zinc levels are modulated by TRPML1-TMEM163 interaction. Cuajungco MP, Basilio LC, Silva J, Hart T, Tringali J, Chen CC, Biel M, Grimm C. Traffic. 2014 Nov;15(11):1247-65. doi: 10.1111/tra.12205. Epub 2014 Sep 2. PMID: 25130899. Select item 25119295 A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV. Chen CC, Keller M, Hess M, Schiffmann R, Urban N, Wolfgardt A, Schaefer M, Bracher F, Biel M, Wahl-Schott C, Grimm C. Nat Commun. 2014 Aug 14;5:4681. doi: 10.1038/ncomms5681. PMID: 25119295. Select item 25072914 KCNMA1 encoded cardiac BK channels afford protection against ischemia-reperfusion injury. Soltysinska E, Bentzen BH, Barthmes M, Hattel H, Thrush AB, Harper ME, Qvortrup K, Larsen FJ, Schiffer TA, Losa-Reyna J, Straubinger J, Kniess A, Thomsen MB, Brüggemann A, Fenske S, Biel M, Ruth P, Wahl-Schott C, Boushel RC, Olesen SP, Lukowski R. PLoS One. 2014 Jul 29;9(7):e103402. doi: 10.1371/journal.pone.0103402. eCollection 2014. Select item 24963162 Peripherin-2 couples rhodopsin to the CNG channel in outer segments of rod photoreceptors. Becirovic E, Nguyen ON, Paparizos C, Butz ES, Stern-Schneider G, Wolfrum U, Hauck SM, Ueffing M, Wahl-Schott C, Michalakis S, Biel M. Hum Mol Genet. 2014 Nov 15;23(22):5989-97. doi: 10.1093/hmg/ddu323. Epub 2014 Jun 24. PMID: 24963162. Select item 24867427 Pathological α-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb. Neuner J, Ovsepian SV, Dorostkar M, Filser S, Gupta A, Michalakis S, Biel M, Herms J. Nat Commun. 2014 May 28;5:3915. doi: 10.1038/ncomms4915. Select item 24756725 TRPML3. Grimm C, Barthmes M, Wahl-Schott C. Handb Exp Pharmacol. 2014;222:659-74. doi: 10.1007/978-3-642-54215-2_26. Review. PMID: 24756725. Select item 24664765 Gene therapy restores vision and delays degeneration in the CNGB1(-/-) mouse model of retinitis pigmentosa. Michalakis S, Koch S, Sothilingam V, Garrido MG, Tanimoto N, Schulze E, Becirovic E, Koch F, Seide C, Beck SC, Seeliger MW, Mühlfriedel R, Biel M. Adv Exp Med Biol. 2014;801:733-9. doi: 10.1007/978-1-4614-3209-8_92. PMID: 24664765. Select item 24526306 Studying mechanosensitive ion channels with an automated patch clamp. Barthmes M, Jose MD, Birkner JP, Brüggemann A, Wahl-Schott C, Koçer A. Eur Biophys J. 2014 Mar;43(2-3):97-104. doi: 10.1007/s00249-014-0944-2. Epub 2014 Feb 14. PMID: 24526306. Select item 24451262 NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa. Arndt L, Castonguay J, Arlt E, Meyer D, Hassan S, Borth H, Zierler S, Wennemuth G, Breit A, Biel M, Wahl-Schott C, Gudermann T, Klugbauer N, Boekhoff I. Mol Biol Cell. 2014 Mar;25(6):948-64. doi: 10.1091/mbc.E13-09-0523. Epub 2014 Jan 22. Select item 24441197 HCN channels: new roles in sinoatrial node function. Wahl-Schott C, Fenske S, Biel M. Curr Opin Pharmacol. 2014 Apr;15:83-90. doi: 10.1016/j.coph.2013.12.005. Epub 2014 Jan 20. Review. PMID: 24441197. Select item 24221507 Auditory event-related signals in mouse ERG recordings. Tanimoto N, Sothilingam V, Gloeckner G, Bryda EC, Humphries P, Biel M, Seeliger MW. Doc Ophthalmol. 2014 Feb;128(1):25-32. doi: 10.1007/s10633-013-9417-7. Epub 2013 Nov 13. PMID: 24221507. Select item 24218458 Sick sinus syndrome in HCN1-deficient mice. Fenske S, Krause SC, Hassan SI, Becirovic E, Auer F, Bernard R, Kupatt C, Lange P, Ziegler T, Wotjak CT, Zhang H, Hammelmann V, Paparizos C, Biel M, Wahl-Schott CA. Circulation. 2013 Dec 17;128(24):2585-94. doi: 10.1161/CIRCULATIONAHA.113.003712. Epub 2013 Nov 11. Select item 24163243 Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2. Michalakis S, Shaltiel L, Sothilingam V, Koch S, Schludi V, Krause S, Zeitz C, Audo I, Lancelot ME, Hamel C, Meunier I, Preising MN, Friedburg C, Lorenz B, Zabouri N, Haverkamp S, Garrido MG, Tanimoto N, Seeliger MW, Biel M, Wahl-Schott CA. Hum Mol Genet. 2014 Mar 15;23(6):1538-50. doi: 10.1093/hmg/ddt541. Epub 2013 Oct 26. Select item 24027293 cGMP accumulation causes photoreceptor degeneration in CNG channel deficiency: evidence of cGMP cytotoxicity independently of enhanced CNG channel function. Xu J, Morris L, Thapa A, Ma H, Michalakis S, Biel M, Baehr W, Peshenko IV, Dizhoor AM, Ding XQ. J Neurosci. 2013 Sep 11;33(37):14939-48. doi: 10.1523/JNEUROSCI.0909-13.2013.