Trauner, Dirk - New York University - Department of Chemistry

个人简介

Dirk Trauner was born and raised in Linz, Austria, studied biology and chemistry at the University of Vienna, and received his undergraduate degree in chemistry from the Free University, Berlin. He then pursued a PhD in chemistry under the direction of Prof. Johann Mulzer, with whom he moved to the University of Frankfurt and then back to Vienna. Following a stint in the Austrian Army, he became a postdoctoral fellow with Prof. Samuel J. Danishefsky at the Memorial Sloan-Kettering Cancer Center. After two great years in New York City, Dr. Trauner joined the Department of Chemistry at the University of California, Berkeley, where he rose through the ranks to become an Associate Professor of chemistry (with tenure). He was also appointed as a member of the Lawrence Berkeley National Laboratory. In the summer of 2008, he moved to the University of Munich, where he currently resides as a Professor of Chemistry and Chemical Biology.

研究领域

The broad objective of Prof. Trauner’s research is to demonstrate the awesome power of chemical synthesis with challenging target molecules and to use it toward the establishment of synthetic biological pathways. He is well known for his pioneering contributions to Optogenetics and Photopharmacology, using synthetic photoswitches to confer light-sensitivity to a broad range of targets. The chemical tools he developed are particularly useful in neuroscience and cell biology but also hold promise as precision therapeutics. Despite his extensive forays into biology and physiology Dr. Trauner remains an organic chemist at heart, as evidenced by the synthesis (and anticipation) of more than one hundred natural products.

近期论文

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Laprell, L.; Tochitsky, I.; Kaur, K.; Manookin, M. B.; Stein, M.; Barber, D. M.; Schoen, C.; Michalakis, S.; Biel, Kramer R. H.: Sumser, M.; Trauner, D.; * Van Gelder, R. N. * Photopharmacological Control of Bipolar Cells Enables the Restoration of Visual Function. J. Clin. Invest., (2017). Cheng. B.; Shchepakin, B.; Kavanaugh, M.;* Trauner, D.* A Photoswitchable Inhibitor of a Glutamate Transporter. ACS Chem Neurosci., (2017). Pernpeintner, C.; Frank, J. A.; Urban, P.; Roeske, C. R.; Pritzl, S. D.; Trauner, D.*; Lohmüller, T.* Light-Controlled Membrane Mechanics and Shape Transitions of Photoswitchable Lipid Vesicles. Langmuir 33, 4083-4089 (2017). Podewin, T.; Broichhagen, J.; Frost, C.; Groneberg, D.; Ast, J.; Meyer-Berg, H.; Fine, N. H. F.; Friebe, A.; Zacharias, M.; Hodson, D. J.; Trauner, D.;* Hoffmann-Röder, A.* Optical Control of a Receptor-linked Guanylyl Cyclase Using a Photoswitchable Peptidic Hormone. Chem. Sci. 8, 4644-4653 (2017). Levitz, J.; Broichhagen, J.; Leippe, P.; Konrad, D.; Trauner D: Isacoff, E. Y. Dual Optical Control and Mechanistic Insights Into Photoswitchable Group II and III Metabotropic Glutamate Receptors. Proc. Natl. Acad. Sci. USA 114, E3546–E3554 (2017). Ketels, M.; Konrad, D.; Karaghiosoff, K.; Trauner, D;* Knochel, P.* Selective Lithiation, Magnesiation and Zincation of Unsymmetrical Azobenzenes Using Continuous Flow. Org. Lett. 19, 1666–1669 (2017). Mehta, Z. B.; Johnston, N. R.; Nguyen-Tu, M.-S.; Broichhagen, J.; Schultz, P.; Larner, D. P.; Leclerc, I.; Trauner, D;* Rutter, G. A.;* Hodson, D. J.* Remote Control of Glucose Homeostasis in vivo Using Photopharmacology. Sci. Rep. 7, 291 (2017). Hao, H.; Trauner. D. Furans as Versatile Synthons: Total Syntheses of Caribenol A and Caribenol B. J. Am. Chem. Soc. 139, 12981-12986 (2017). Matsuura, B. S.; Kölle, P.; de Vivie-Riedle, R.*; Trauner, D.*; Meier, R.* Unravelling Photochemical Relationships Amongst Natural Products from Aplysia dactylomela. ACS Central Sci. 3, 39–46 (2017). Hartrampf, F.; Furukawa, T.; Trauner, D. A Conia-Ene-Type Cyclization Under Basic Conditions Enables an Efficient Synthesis of (−)-Lycoposerramine R. Angew. Chem. Int. Ed. 56, 893–896 (2017). Volpin, G; Veprek, N. A.; Bellan, A. B.; Trauner, D. Enantioselective Synthesis and Racemization of (–)-Sinoracutine. Angew. Chem. Int. Ed. 56, 897–901 (2017). Trads, J. B.; Burgstaller, J.; Laprell, L.; Konrad, D. B.; de la Osa de la Rosa, L.; Weaver, C. D.; Trauner. D.*; Barber, D.* Optical Control of GIRK Channels Using Visible Light. Org. Biomol. Chem. 15, 76–81 (2017). Frank, J. A.; Franquelim, H. A.; Schwille, P.*; Trauner. D.* Optical Control of Lipid Rafts with Photoswitchable Ceramides. J. Am. Chem. Soc. 138, 12981–12986 (2016). Barber, D. M.; Liu, S.-A.; Gottschling, K.; Sumser, M.; Hollmann, M.; Trauner, D. Optical Control of AMPA Receptors Using a Photoswitchable Quinoxaline-2,3-dione Antagonist. Chem. Sci. 8, 611–615 (2017). Johnston, N. R.; Mitchell, R. K.; Haythorne, E.; Paiva Pessoa, M.; Semplici, F.; Ferrer, J.; Piemonti, L.; Marchetti, P.; Bugliani, M.; Bosco, D.; Berishvili, E.; Duncanson, P.; Watkinson, M.; Broichhagen, J.; Trauner, D.; Rutter, G. A.; Hodson, D. J. Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose. Cell Metabolism 24, 389–401 (2016). Frank, J. A.; Yushchenko, D.; Hodson, D. A.; Lipstein, N.; Nagpal, J.; Rutter, G. A.; Rhee, J.-S.; Gottschalk, A.; Brose, N.; Schultz, C.; Trauner. D. Photoswitchable Diacylglycerols Enable Optical Control of Protein Kinase C. Nature Chem. Biol. 12, 755–762 (2016). Meier, R., Trauner, D A Synthesis of (±)-Aplydactone. Angew. Chem. Int. Ed. 55, 11251–11255 (2016). Damijonaitis, A.; Barber, D. M.; Trauner, D. The Photopharmacology of Nicotinic Acetylcholine Receptors. Neurotransmitter 3, 1292 (2016). Berlin, S.; Szobota, S.; Reiner, A.; Kienzler, M. A.; Guyon, A.; Trauner. D.; Isacoff. E. Y. A Family of Photoswitchable NMDA Receptors. eLife 5, e12040 (2016). Konrad, D.; Frank, J. A.; Trauner, D. Synthesis of Red-shifted Azobenzene Photoswitches via Late-Stage Functionalization. Chem. Eur. J. 22, 4364–4368 (2016).