刘定斌 - 南开大学 - 药物化学生物学国家重点实验室

个人简介

Prof.Dingbin Liu received his B.S. in 2006 from Lanzhou University and his Ph.D. in 2012 from the National Center for Nanoscience and Technology, China (NCNST) under the direction of Prof. Xingyu Jiang. After a short postdoctoral training at Dr. Xiaoyuan Chen' lab at the National Institutes of Health (NIH) under the support of NRC NIH/NIST Joint Postdoctoral Associateship, he joined the College of Chemistry at Nankai University in 2014. He is also a principal investigator at the State Key Laboratory of Medicinal Chemical Biology and the Collaborative Innovation Center of Chemical Science and Engineering (Tianjin). Prof. Liu was elected as the member of the Hundred Youth Academic Leader of Nankai University.

研究领域

1) background-free Raman spectroscopy, 2) stimulus-responsive biosensing system, 3) high-sensitivity assays for rapid analysis, and 4) labeling and analysis of extracellular vesicles.

近期论文

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Wenshuai Li, Jingqi Li, Hua Xu, Hongmei Gao and Dingbin Liu*, Rapid and visual identification of β-lactamase subtypes for precision antibiotic therapy. Nature Communications, 2024, 15, 719. Qiang Li, Zhaowei Zhang, Fengchao Wang, Xiang Wang, Saisong Zhan, Xiaoqing Yang, Chen Xu and Dingbin Liu*, Reversible Zwitterionic Coordination Enables Rapid, High-yield, and High-purity Isolation of Extracellular Vesicles from Biofluids. Science Advances, 2023, 9: eadf4568. Wei Zhang, Long Ngo, Simon Chang-Hao Tsao, Dingbin Liu*, and Yuling Wang*, Engineered Cancer-Derived Small Extracellular Vesicle-Liposome Hybrid Delivery System for Targeted Treatment of Breast Cancer. ACS Applied Materials & Interfaces, 2023, 15: 16420-16433. Lizong Tang, Congrui Zhao, Yufei Liu, Jie Zhou, Yunsheng Dong, Jiaxing Huang, Tingting Yang, Hui Xiao, Dingbin Liu*, Shufang Wang*, and Hong Cai*, GelMA Hydrogel Loaded with Extracellular Vesicles Derived from Umbilical Cord Mesenchymal Stem Cells for Promoting Cutaneous Diabetic Wound Healing. ACS Omega, 2023, 8(11): 10030-10039. Zhiyou Zong, Xinzhuo Liu, Zhuo Ye, and Dingbin Liu*, A Double-switch pHLIP System Enables Selective Enrichment of Circulating Tumor Microenvironment-derived Extracellular Vesicles. Proceedings of National Academy of Sciences of the United States of America, 2023, 120(2): e2214912120. Zhaowei Zhang#, Xuehui Liu#, Xiaoqing Yang#, Ying Jiang, Ang Li, Jiying Cong, Yuwei Li, Qinjian Xie, Chen Xu*, and Dingbin Liu*, Identification of Faecal Extracellular Vesicles as Novel Biomarkers for Non-invasive Diagnosis and Prognosis of Colorectal Cancer. Journal of Extracellular Vesicles, 2023, 12(1): 12300. Wenshuai Li, Jingjing Wang, Chen Li, Zhiyou Zong, Jinzhong Zhao, Hongmei Gao, and Dingbin Liu*, Achieving Ultrasensitive Chromogenic Probes for Rapid, Direct Detection of Carbapenemase-Producing Bacteria in Sputum JACS Au, 2023, 3(1): 227-238. Fengchao Wang, Ning Sun, Qiang Li, Jie Yang, Xiaoqing Yang, and Dingbin Liu*, Self-Referenced Synthetic Urinary Biomarker for Quantitative Monitoring of Cancer Development. Journal of the American Chemical Society, 2023, 145(2): 919-928.[cover picture] Wenjuan Wu, Congcong Yin, Aiqin Yue*, Jingping Niu, Weijun Du*, Dingbin Liu, and Jinzhong Zhao*, Rapid and Visual Detection of Soybean Mosaic Virus SC7 with a Loop-mediated Isothermal Amplification Strategy. Sensors and Actuators B-Chemical, 2022, 373: 132733. Zhuo Ye, Moxuan Ji, and Dingbin Liu*, Advances of Optical Probes in Atherosclerosis Imaging. Chemical Journal of Chinese Universities-Chinese, 2022, 43(12): 20220556. Wei Zhang, Douglas H. Campbell, Bradley J. Walsh, Nicolle H. Packer, Dingbin Liu*, and Yuling Wang*, Cancer-derived Small Extracellular Vesicles: Emerging Biomarkers and Therapies for Pancreatic Ductal Adenocarcinoma Diagnosis/Prognosis and Treatment. Journal of Nanobiotechnology, 2022, 20:446. Kefeng Wu, Qiang Li*, Chi Yao, Dayong Yang*, and Dingbin Liu*, Trojan Horse Delivery of Spherical Nucleic Acid Probes into the Cytoplasm for High-fidelity Imaging of MicroRNAs. Analytical Chemistry, 2022, 94(31): 10942-10948. Zhuo Ye, Moxuan Ji, Kefeng Wu, Jie Yang, An-An Liu, Wei Sun, Dan Ding, Dingbin Liu*, "In- Sequence High-Specificity Dual-Reporter Unlocking of Fluorescent Probe Enables the Precise Identification of Atherosclerotic Plaques", Angew. Chem. In. Ed., 2022, Doi: 10.1002/anie.202204518. Kai Wang, Heqi Gao, Yuwen Zhang, Hongyu Yan, Jianghua Si, Xingyan Mi, Shuang Xia, Xuequan Feng, Dingbin Liu, Deling Kong, Ting Wang*, Dan Ding*, 'Highly Bright AIE Nanoparticles by Regulating the Substituent of Rhodanine for Precise Early Detection of Atherosclerosis and Drug Screening', Advanced Materials, 2022, Doi: 10.1002/adma.202106994. Qian Liu, Fang Wu, Huixia Di, Yingna Bi, Meng Meng, Dingbin Liu, Yongmei Yin*, Rimo Xi*, 'A Novel SERS Biosensor for Ultrasensitive Detection of Mercury(II) in Complex Biological Samples' Sensors and Actuators B-Chemical', 2022, 351, DOI: 10.1016/J.SNB.2021.130934. Xuehui Liu, Zhiyou Zong, Xinzhuo Liu, Qiang Li, Ang Li, Chen Xu, Dingbin Liu*. 'Stimuli-mediated Specific Isolation of Exosomes from Blood Plasma for High-throughput Profiling of Cancer Biomarkers'. Small Methods, 2022, DOI: 10.1002/smtd.202101234. Wen Zhou, Xiaoyue Ni, Chen Xie, Quli Fan, Dingbin Liu*. 'Advanced Technologies for Single-cell in Situ Protein Profiling', Science China-Chemistry. 65(1), 48-67. Guorui Wu, Wenshuai Li, Weijun Du, Aiqin Yue*, Jinzhong Zhao and Dingbin Liu*. 'In-situ Monitoring of Nitrile-bearing Pesticide Residues BY Background-free Surface-enhanced Raman Spectroscopy', Chinese Chemical Letters, 2022, 33(1): 519-522. Xinzhuo Liu, Zhiyou Zong, Mindan Xing, Xuehui Liu, Jia Li, and Dingbin Liu*. 'pH-Mediated Clustering of Exosomes: Breaking Through the Size Limit of Exosome Analysis in Conventional Flow Cytometry.' Nano Letters, 2021, 21(20), 8817-8823. Zhiwen Xu, Cai Zhang, Xiang Wang and Dingbin Liu*. 'Release Strategies of Silver Ions from Materials for Bacterial Killing.' ACS Applied Bio Materials, 2021, 4(5): 3985-3999. Zhiwen Xu, Cai Zhang, Yunjian Yu, Wenshuai Li, Zhuang Ma, Jingjing Wang, Xinge Zhang, Hongmei Gao* and Dingbin Liu*. 'Photoactive Silver Nanoagents for Backgroundless Monitoring and Precision Killing of Multidrug-Resistant Bacteria.' Nanotheranostics, 2021, 5(4): 472-487. Yongxi Zhao, Xiaolei Zuo, Qian Li, Feng Chen, Yan-Ru Chen, Jinqi Deng, Da Han, Changlong Hao, Fujian Huang, Yanyi Huang, Guoliang Ke, Hua Kuang, Fan Li, Jiang Li, Min Li, Na Li, Zhenyu Lin, Dingbin Liu, Juewen Liu, Libing Liu, Xiaoguo Liu, Chunhua Lu, Fang Luo, Xiuhai Mao, Jiashu Sun, Bo Tang, Fei Wang, Jianbin Wang, Lihua Wang, Shu Wang, Lingling Wu, Zai-Sheng Wu, Fan Xia, Chuanlai Xu, Yang Yang, Bi-Feng Yuan, Quan Yuan, Chao Zhang, Zhi Zhu, Chaoyong Yang*, Xiao-Bing Zhang*, Huanghao Yang*, Weihong Tan* and Chunhai Fan*, 'Nucleic Acids Analysis' Science China Chemistry, 2021, 64: 171–203. Congcong Yin, Qiaoling Zhao, Aiqin Yue, Weijun Du, Dingbin Liu, Jinzhong Zhao*, Yongpo Zhang and Min Wang. 'Colorimetric Detection of Class A Soybean Saponins by G-Quadruplex-Based Hybridization Chain Reaction.' Journal of Analytical Methods in Chemistry, 2020, 2020: 8813239. Cai Zhang, Xinzhuo Liu, Zhiwen Xu and Dingbin Liu*. 'Multichannel Stimulus-Responsive Nanoprobes for H2O2 Sensing in Diverse Biological Milieus.' Analytical Chemistry, 2020, 92(18): 12639-12646. Yingna Bi, Huixia Di, Erzao Zeng, Qiang Li, Wenshuai Li, Jie Yang and Dingbin Liu*. 'Reliable Quantification of pH Variation in Live Cells Using Prussian Blue-Caged Surface-Enhanced Raman Scattering Probes.' Analytical Chemistry, 2020, 92(14): 9574-9582. Wenshuai Li, Guorui Wu, Min Wang, Aiqin Yue*, Weijun Du*, Dingbin Liu and Jinzhong Zhao*. 'Colorimetric Detection of class A Soybean Saponins by Coupling DNAzyme with the Gap Ligase Chain Reaction.' Analytical Methods, 2020, 12(26): 3361-3367. Cai Zhang, Xiaoyu Cui, Jie Yang, Xueguang Shao, Yuying Zhang and Dingbin Liu*. 'Stimulus-responsive Surface-enhanced Raman Scattering: a “Trojan Horse” Strategy for Precision Molecular Diagnosis of Cancer.' Chemical Science, 2020, 11(24): 6111-6120. Wenshuai Li, Guorui Wu, Xijing Zhang, Aiqin Yue, Weijun Du, Jinzhong Zhao* and Dingbin Liu*. 'Advances in Bacterial Detection Based on Raman Spectroscopy.' Chemical Journal of Chinese Universities-Chinese, 2020, 41(5): 872-883. Qiang Li, Fengchao Wang, Jie Yang and Dingbin Liu*. 'Direct Cytoplasm Delivery of Gold Nanoparticles for Real-time Apoptosis Detection.' Nano Research, 2020, 13(3): 853-860. Xuehui Liu, Xiaoman Liu, Pengfei Rong* and Dingbin Liu*. 'Recent Advances in Background-free Raman Scattering for Bioanalysis.' Trac-Trends in Analytical Chemistry, 2020, 123: 115765. Shuxin Song, Jingyu Wang, Na Song, Huixia Di, Dingbin Liu and Zhilin*. 'Peptide Interdigitation-induced Twisted Nanoribbons as Chiral Scaffolds for Supramolecular Nanozymes.' Nanoscale, 2020, 12(4): 2422-2433. Ying Jiang, Lei Wang, Pengjuan Zhang, Xuehui Liu, Huixia Di, Jie yang, Shulin Liu, Daiwen Pang and Dingbin Liu*. 'Chemoenzymatic Labeling of Extracellular Vesicles for Visualizing Their Cellular Internalization in Real Time.' Analytical Chemistry, 2020, 92(2): 2103-2111.