当前位置: X-MOL首页全球导师 国内导师 › 程义云

个人简介

主要研究方向为基因、蛋白质等生物大分子的递送技术,发展了一系列高性能载体用于生物治疗。承担国家自然科学基金杰出青年基金、国家自然科学基金重点项目、国家重点研发计划、国家自然科学基金优秀青年基金等项目十余项。前期研究成果在Nat. Mater., Nat. Nanotechnol., JACS, Angew. Chem. Int. Ed., Adv. Mater., Nat. Commun., Sci. Adv., Nano Lett., Adv. Funct. Mater., Biomaterials等高水平刊物发表论文200余篇,论文他引10000余次,入选中国高被引学者榜单。担任Biomaterials Science等多个国际、国内刊物编委。获得中国化学会青年化学奖、中国化学会高分子青年学者奖、上海市科技进步一等奖、上海市优秀学术带头人、上海市青年五四奖章等。 教育经历 1997.09-2000.06 江苏省姜堰中学 高中 2000.09-2004.06 中国科学技术大学 高分子科学与工程系 学士 2004.09-2008.12 中国科学技术大学 生命科学学院 博士 工作经历 2009.02-2009.10 Washington University in St.Louis, 博士后 2010.03至今 华东师范大学 生命科学学院,教授、博士生导师 承担项目及获得的荣誉 中国化学会高分子青年化学奖(2019) 中国青年化学家元素周期表(2019,氟元素代言人) 国家自然科学基金杰出青年基金(2017) 上海市青年五四奖章(2016) 中国化学会青年化学奖(2015) 上海市优秀学术带头人(2015) 教育部霍英东教育基金(2015) 国家自然科学基金优秀青年基金(2013) 上海市青年科技启明星(2013) 教育部新世纪优秀人才支持计划(2011) 安徽省优秀博士学位论文(2011) 全国优秀博士学位论文提名(2011) 上海市曙光学者(2010) 中国科学院优秀博士学位论文(2010) Emerging Investigators (JMCB, 2014, 2018) Emerging Investigators (Biomater. Sci., 2018) Pioneering Investigators (Chem. Commun., 2022)

研究领域

基因递送与基因治疗 蛋白质、多肽胞内递送 高分子转化医学 医用凝胶材料

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Xu J, Lv J, Zhuang Q, Yang Z, Cao Z, Xu L, Pei P, Wang C, Wu H, Dong Z, Chao Y, Wang C, Yang K, Peng R*, Cheng YY*, Liu Z*. A general strategy towards personalized nanovaccines based on fluoropolymers for post-surgical cancer immunotherapy. Nat. Nanotechnol., 2020, 15, 1043-1052. Lv J., Wang C, Li H, Li Z, Fan Q, Zhang Y, Li Y. Wang H*, Cheng YY*. Bifunctional and bioreducible dendrimer bearing a fluoroalkyl tail for efficient protein delivery both in vitro and in vivo. Nano Lett., 2020, 20, 8600-8607. Rong GY, Wang CP, Chen LJ, Yan Y, Cheng YY*. Fluoroalkylation promotes cytosolic peptide delivery. Science Advances, 2020, 6, eaaz1774. Shen W, Wang R, Fan Q, Gao X, Wang H, Shen Y, Li YW*, Cheng YY*. Natural Polyphenol Inspired Polycatechols for Efficient siRNA Delivery. CCS Chem., 2020, 2(3), 146-157. Ren L, Lv J, Wang H, Cheng YY*. A Coordinative Dendrimer Achieves Excellent Efficiency in Cytosolic Protein and Peptide Delivery. Angew. Chem. Int. Ed., 2020, 59, 4711-4719. Liu CY, Wang T, Wang H, Zhang S, Ping Y*, Cheng YY*. A Boronic acid-rich Dendrimer with Robust and Unprecedented Efficiency for Cytosolic Protein Delivery and CRISPR-Cas9 Gene Editing. Science Advances, 2019, 5, eaaw8922. Zhang S, Wang CP, Chang H, Zhang Q*, Cheng YY*. Off-On Switching of Enzyme Activity by Near-infrared Light-Induced Photothermal Phase Transition of Nanohybrids, Science Advances, 2019, 5, eaaw4252. Zhang ZJ, Shen WW, Ling J, Yan Y, Hu JJ, Cheng YY*. The Fluorination Effect of Fluoroamphiphiles in Cytosolic Protein Delivery, Nat. Commun., 2018, 9, 1377. (Highlighted by Nature Research Chemistry Community; Chemistry of Life) Shen W, Wang Q, Shen Y, Gao X, Li L, Yan Y, Wang H, Cheng YY*. Green Tea Catechin Dramatically Promotes RNAi Mediated by Low Molecular Weight Polymers, ACS Cent. Sci., 2018, 4, 1326-1333. (Highlighted by ACS, ScienceDaily, EurekAlert, World Tea News, Phys.Org, Science Foundation in China, 中国科学报) Wang CP, Sang H, Wang Y, Zhu F, Hu X, Wang X, Wang X, Li Y*, Cheng YY*. Foe to Friend: Supramolecular Nanomedicines Consisting of Natural Polyphenols and Bortezomib, Nano Lett., 2018, 18, 7045-7051. Wang CP, Zhang Q, Wang X, Chang H, Zhang S, Tang Y, Xu J, Qi R, Cheng YY*. Dynamic Modulation of Enzyme Activity by Near-infrared Light, Angew. Chem. Int. Ed., 2017, 56, 6767-6772 (Highlighted by Advanced Science News). Chang H, Lv J, Gao X, Wang X, Wang H, Chen H, He X, Li L, Cheng YY*. Rational Design of a Polymer with Robust Efficacy for Intracellular Protein and Peptide Delivery, Nano Lett., 2017, 17, 1678-1684. (Highlighted by Faculty of 1000) Zhou ZJ, Wang YT, Yan Y, Zhang Q*, Cheng YY*. Dendrimer-templated Ultrasmall and Multifunctional Photothermal Agents for Efficient Tumor Ablation, ACS Nano, 2016, 10, 4863-4872. Yang JP, Zhang Q, Chang H, Cheng YY*. Surface-engineered Dendrimers in Gene Delivery, Chem. Rev., 2015, 115(11), 5274-5300. (Cover Story, ESI 1% highly cited papers) Wang H, Wang YT, Wang Y, Li TF, Liu HM, Zhang Q, Cheng YY*. Self-assembled Fluorodendrimers Combine the Features of Lipid and Polymeric Vectors in Gene Delivery. Angew. Chem. Int. Ed., 2015, 54, 11647-11651. Wang MM, Liu HM, Li Lei, Cheng YY*. A Fluorinated Dendrimer Achieves Excellent Gene Transfection Efficiency at Extremely Low Nitrogen to Phosphorus Ratios, Nat. Commun., 2014, 5, 3053. (ESI 1% highly cited papers) Wang XY, Cai XP, Hu JJ, Shao NM, Wang F, Zhang Q, Xiao J*, Cheng YY*. Glutathione-triggered "Off-on" Release of Anticancer Drugs from Dendrimer-encapsulated Gold Nanoparticles, J. Am. Chem. Soc., 2013, 135, 9805-9810. Liu HM, Wang H, Yang WJ, Cheng YY*. Disulfide Cross-linked Low Generation Dendrimers with High Gene Transfection Efficacy, Low Cytotoxicity, and Low Cost, J. Am. Chem. Soc.? 2012? 134, 17680-17687. Hu JJ, Xu TW, Cheng YY*. NMR Insights into Dendrimer-based Host-guest Systems, Chem. Rev., 2012, 112, 3856-3891. Cheng YY*? Zhao LB? Li YW? Xu TW*. Design of Biocompatible Dendrimers for Cancer Diagnosis and Therapy: Current Status and Future Perspectives? Chem. Soc. Rev.? 2011? 40? 2673-2703. (ESI 1% highly cited papers) Zhao LB? Wu QL? Cheng YY*? Zhang JH? Wu JH? Xu TW*. High-throughput Screening of Dendrimer-binding Drugs? J. Am. Chem. Soc.? 2010? 132? 13182-13184. Yavuz MS?? Cheng YY?? Chen JY?? Cobley CM? Zhang Q? Rycenga M? Xie JW? Kim C? Schwartz AG? Wang LV? Xia YN*. Gold Nanocages Covered by Smart Polymers for Controlled Release with Near-infrared Light? Nat. Mater.? 2009? 8, 935-939. (?共同第一作者; Highlighted by Science Daily? The New York Times; ESI 1% highly cited papers) Gao X, Li L, Cai X, Huang Q, Xiao J*, Cheng YY*. Targeting Nanoparticles for Diagnosis and Therapy of Bone Tumors: Opportunities and Challenges. Biomaterials. 2021, 265, 120404. Lv J, Fan Q, Wang H, Cheng YY*. Polymers for Cytosolic Protein Delivery, Biomaterials, 2019, 218, 119358. Liu CY, Shen WW, Li BN, Li TF, Chang H, Cheng YY*. Natural Polyphenols Augment Cytosolic Protein Delivery by a Functional Polymer, Chem. Mater., 2019, 31, 1956-1965. Li MY, Wang H, Hu JF, Hu J, Zhang S, Yang Z, Li YW, Cheng YY*. Smart Hydrogels with Antibacterial Properties Built from All Natural Building Blocks, Chem. Mater., 2019, doi: 10.1021/acs.chemmater.9b02547. Li GZ, Yuan S, Deng D, Ou T, Li Q, Sun R, Lei Q, Wang X, Shen W, Cheng YY*, Liu Z*, Wu S*. Fluorinated Polyethylenimine to Enable Transmucosal Delivery of Photosensitizer-conjugated Catalase for Photodynamic Therapy of Orthotopic Bladder Tumors Postintravesicle Instillation. Adv. Funct. Mater., 2019, 1901932. Xu J, Wang H, Xu LG, Chao Y, Wang C, Han X, Dong Z, Chang H, Peng R*, Cheng YY*, Liu Z*. Nanovaccine Based on a Protein-delivering Dendrimer for Efffective Antigen Cross-presentation and Cancer Immunotherapy, Biomaterials, 2019, 207, 1-9. Li G, Lei Q, Wang F, Deng D, Wang S, Tian L, Shen W, Cheng YY*, Liu Z*, Wu S*. Fluorinated Polymer Mediated Transmucosal Peptide Delivery for Intravesical Instillation Therapy, Small, 2019, 1900936. Zhou ZJ, Fan T, Yan Y, Zhang S, Zhou Y, Deng H, Cai X, Xiao J, Song D, Zhang Q*, Cheng YY*. One Stone with Two Birds: Phytic Acid-capped Platinum Nanoparticles for Targeted Combination Therapy of Bone Tumors, Biomaterials, 2019, 194, 130-138. Zhou Z, Yan Y, Wang L, Zhang Q*, Cheng YY*. Melanin-like Nanoparticles Decorated with an Autophagy-inducing Peptide for Efficient Targeted Photothermal Therapy, Biomaterials, 2019, 203, 63-72. Lv J, He B, Yu J, Wang Y, Wang C, Zhang S, Wang H, Hu J, Zhang Q, Cheng YY*. Fluoropolymers for Intracellular and In Vivo Protein Delivery, Biomaterials, 2018, 182, 167-175. Wang CP, Wang D, Dai TJ, Xu P, Wu PL, Zou Y, Yang P, Hu JJ, Li YW*, Cheng YY*. Skin Pigmentation-Inspired Polydopamine Sunscreens, Adv. Funct. Mater., 2018, 1802127. Wang Y, Huang Q, He X, Chen H, Zou Y, Li Y, Lin K, Cai X, Xiao J, Zhang Q*, Cheng YY*. Multifunctional Melanin-like Nanoparticles for Bone-targeted Chemo-photothermal Therapy of Malignant Bone Tumors and Osteolysis, Biomaterials, 2018, 183, 10-19. Hu JJ, Chen YH, Li YQ, Zhou ZJ, Cheng YY*. A Thermo-degradable Hydrogel with Light-tunable Degradation and Drug Release, Biomaterials, 2017, 112, 133-140. (Highlighted by Faculty of 1000) Zhou Z, Yan Y, Hu K, Zou Y, Li Y, Ma R, Zhang Q*, Cheng YY*. Autophagy Inhibition Enabled Efficient Photothermal Therapy at a Mild Temperature, Biomaterials, 2017, 141, 116-121. Wang X, Wang CP, Wang XY, Wang YT, Zhang Q*, ?Cheng YY?*. A Poly(dopamine) Nanoparticle-Knotted Poly(ethylene glycol) Hydrogel for On-demand Drug Delivery and Chemo-photothermal Therapy, Chem. Mater., 2017, 29, 1370-1376. Wang YT, Yang J, Liu HM, Wang XY, Zhou ZJ, Huang Q, Song DW, Cai XP, Li L, Lin KL, Xiao JR, Liu PF*, Zhang Q*, Cheng YY*. Osteotropic Peptide-mediated Bone Targeting for Photothermal Treatment of Bone Tumors, Biomaterials, 2017, 114, 97-105. Hu JJ, Quan YC, Lai YP, Zheng Z, Hu ZQ, Wang XY, Dai TJ, Zhang Q, Cheng YY*. A Smart Aminoglycoside Hydrogel with Tunable Gel Degradation, on-demand Drug Release, and High Antibacterial Activity, J. Control. Release, 2017, 247, 145-152. Zhou ZJ, Hu KW, Ma R, Yan Y, Ni B, Zhang YJ, Wen LP, Zhang Q*, Cheng YY*. Dendritic Platinum-Copper Alloy Nanoparticles as Theranostic Agents for Multimodal Imaging and Combined Chemo-photothermal Therapy, Adv. Funct. Mater., 2016, 26, 5971-5978. (Cover Story) Wang CP, Wang XY, Dong KY, Luo J, Zhang Q*, Cheng YY*. Injectable and Responsively Degradable Hydrogel for Personalized Photothermal Therapy, Biomaterials, 2016, 104, 129-137. Wang XY, Zhang JS, Wang YT, Wang CP, Xiao J*, Zhang Q*, Cheng YY*. Multi-responsive Photothermal-chemotherapy with Drug-loaded Polydopamine Nanoparticles for Synergetic Tumor Ablation, Biomaterials, 2016, 81, 114-124. (ESI 1% highly cited papers) Wang CP, Cai XP, Zhang JS, Wang XY, Wang Y, Ge H, Yan H, Huang Q, Xiao J*, Zhang Q*, Cheng YY*. Trifolium-like Platinum Nanoparticle-mediated Photothermal Therapy Inhibits Tumor Growth and Osteolysis in a Bone Metastasis Model. Small, 2015, 11, 2080-2086. (Highlighted by MaterialsViews China) Wang F, Wang YT, Wang H, Shao NM, Chen YY, Cheng YY*. Synergistic Effect of Amino Acids Modified on Dendrimer Surface in Gene Delivery, Biomaterials, 2014, 35, 9187-9198. (Highlighted by Faculty of 1000) Liu HM, Wang Y, Wang MM, Xiao JR, Cheng YY*. Fluorinated Poly(propylenimine) Dendrimers as Gene Vectors, Biomaterials, 2014, 35, 5407-5413. Wang MM, Cheng YY*. The Effect of Fluorination on the Transfection Efficacy of Surface-engineered Dendrimers? Biomaterials? 2014, 35, 6603-6613. Hu JJ, Su YZ, Zhang HF, Xu TW*, Cheng YY*. Design of Interior-functionalized Fully Acetylated Dendrimers for Anticancer Drug Delivery, Biomaterials, 2011, 32, 9950-9959.

学术兼职

2020年至今:Giant 编委 2019年至今:Biomaterials Science 编委 2019年至今:Chinese Chemical Letters 编委 2014年至今:Letters in Drug Design & Discovery 编委 2010年至今:Current Drug Discovery Technologies 编委 2016年:Topics in Current Chemistry 客座编辑

推荐链接
down
wechat
bug