韩鹤友 - 华中农业大学

个人简介

韩鹤友，男，博士，华中农业大学二级教授，博士生导师。湖北省政协委员，湖北省人民政府参事，曾任华中农业大学研究生院常务副院长、理学院院长。享受国务院政府特殊津贴和湖北省政府专项津贴。教育部新世纪优秀人才，武汉市学科带头人，全国生化检测标准化技术委员会委员，全国林业生物质材料标准化技术委员会委员；湖北省自然科学基金创新团队带头人；美国化学会会员，中国化学会会员，湖北省化学与化工学会常务理事；湖北省化学与化工学会常务理事；华中农业大学农业微生物学国家重点实验室PI；华中农业大学化学生物学研究所所长。《Advanced Material Letters》、《Nanomaterials》、《Current Cancer Reports》、《Materials Physics and Chemistry》、《American Journal of Biomedical Sciences》、《分析科学学报》、《光散射学报》等杂志编委。主要研究方向为食品安全、农业纳米教授、纳米药物递送及其抗菌/抗肿瘤/抗病毒应用研究等，以第一作者或通讯作者在Chemical Society Reviews、Nature Communications、Science Advances、Advanced Materials、 Angewandte_Chemie、ACS Nano等国际重要专业学术期刊发表SCI论文文章被引10019次，H因子172（Google Scholar，2022.6.21）；获授权发明专利13项；获省部级科学技术奖6项。主持项目：基于微流控芯片电化学发光检测的兽药残留分析新技术研究（新世纪优秀人才支持计划，NCET－05－0668）；量子点标记及成像技术用于猪链球菌2型的快速检测及致病机理研究（国家自然科学基金，20675034）；植物油脂绿色转化关键技术及产品（“863”重点项目，2007AA100703，承担其中“生物柴油磁性纳米固体碱催化剂的研制及配套生产技术研究” ）；基于量子点标记的猪传染性胸膜肺炎快速诊断技术研究（武汉市学科带头人计划，200851430484）；近红外量子点成像用于Bt毒素受体确认及Bt杀虫机理研究（国家自然科学基金，20975042）；转基因动物抽样及快速、高通量检测技术体系研究（转基因生物新品种培养科技重大专项，2009ZX08012-015B子项目）；中美拉曼实时便捷检测装备化研究及食品安全与口岸应用（国际科技合作项目，2008DFA40270）；动物重大疫病纳米分子成像诊断及应用基础研究（湖北省自然科学基金创新群体项目，2011CDA115）；量子点双光子荧光成像技术用于猪圆环病毒2型致病机理研究（国家自然科学基金，21175051/B050902）；量子点近红外电致化学发光及其成像研究（国家自然科学基金，21375043/B050207）。

研究领域

主要研究方向为纳米生物分析、肿瘤纳米靶向治疗、纳米材料抗菌抗病毒应用研究等

近期论文

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Wenjing Wang, Zhiyong Song, Qurban Ali, Mubassir Ali, Ni Hong, Guoping Wang and Heyou Han. Time-resolved fluorescent microsphere lateral flow biosensors for rapid detection of Candidatus Liberibacterasiaticus: Plant Biotechnology Journal (2022)20,pp. 1235-1237. Yang Wu, Guiyun Deng, Zhiyong Song, Kai Zhang, Jiamin Deng, Kai Jiang, Heyou Han. Enhancing antibacterial immunotherapy for bacterial pneumonia via nanovaccines coated with outer membrane vesicles: Chemical Engineering Journal. 436(2022),135040 Guiyun Deng,Yang Wu, Zhiyong Song, Shoujun Li, Moqing Du, Jiamin Deng, Quan Xu, Liu Deng, Hagar Shendy Bahlol, and Heyou Han. Tea Polyphenol Liposomes Overcome Gastric Mucus to Treat Helicobacter Pylori Infection and Enhance the Intestinal Microenvironment: ACS Appl. Mater. Interfaces. 2022, 14, 13001-13012 Jiawen Li, Caiqian Wang, Wenjing Wang, Ling Zhao, Heyou Han. Dual-Mode Immunosensor for Electrochemiluminescence Resonance Energy Transfer and Electrochemical Detection of Rabies Virus Glycoprotein Based on Ru(bpy)32+-Loaded Dendritic Mesoporous Silica Nanoparticles: Analytical Chemistry. 2022, 94, 21, 7655-7664 Shanshan Liu, Chunyan Wang, Zongmei Wang, Kaikai Xiang, Yutian Zhang, Gao-Chao Fan, Ling Zhao, Heyou Han, Wenjing Wang.Binding induced isothermal amplification reaction to activate CRISPR/ Cas12a for amplified electrochemiluminescence detection of rabies viral RNA via DNA nanotweezer structure switching: Biosensors and Bioelectronics. 2022, 204, 114078 Shanshan Liu, Kaikai Xiang, Chunyan Wang, Yutian Zhang, Gao-Chao Fan, Wenjing Wang, Heyou Han. DNA Nanotweezers for Biosensing Applications: Recent Advances and Future Prospects[J]. 2022. Zhang, W.; Liu, J.; Li, X.; Zheng, Y.; Chen, L.; Wang, D.; Foda, M. F.; Ma, Z.; Zhao, Y.; Han, H., Precise Chemodynamic Therapy of Cancer by Trifunctional Bacterium-Based Nanozymes. ACS Nano 2021. Zhaoyu Ma,Mohamed F. Foda,Yanli Zhao*,Heyou Han*.Multifunctional Nanosystems with Enhanced Cellular Uptake for Tumor Therapy. Advanced healthcare materials.2021,e2101703. Ma, Z., Zhang, Y., Dai, X., Zhang, W., Foda, M. F., Zhang, J., Zhao, Y., Han, H., Selective Thrombosis of Tumor for Enhanced Hypoxia-Activated Prodrug Therapy. Adv. Mater. 2021, 2104504. Zhaoyu Ma,Mohamed F. Foda,Huageng Liang*,Yanli Zhao*,Heyou Han*.In Situ Nanozyme-Amplified NIR-II Phototheranostics for Tumor-Specific Imaging and Therapy.Adv. Funct. Mater. 2021, 2103765. Wenjing Wang,Yun Li,Axiu Nie,Gao-Chao Fan,and Heyou Han *.“A portable SERS reader coupled with catalytic hairpin assembly for sensitive microRNA-21 lateral flow sensing” Analyst,2021,146,848 Yang Wu,Guiyun Deng,Kai Jiang, Huajuan Wang,Zhiyong Song**,Heyou Han*.“Photothermally triggered nitric oxide nanogenerator targeting type IV pili for precise therapy of bacterial infections”.Biomaterials 268 (2021) 120588. Kaikai Xiang, Gang Chen, AXiu Nie,Wenjing Wang *,Heyou Han *.“Silica-based nanoenzymes for rapid and ultrasensitive detection of mercury ions”.Sensors & Actuators: B. Chemical 330 (2021) 129304. Huajuan Wang,Jin Zhang,Zhiyong Song,Yongli Mu,Mohamed F. Foda,Yang Wu,Heyou Han*.“An intelligent platform based on acidity-triggered aggregation of gold nanoparticles for precise photothermal ablation of focal bacterial infection”.Chemical Engineering Journal 407(2021)127076. Jing Ma,Wenjing,Wang,Yun Li,Zhicheg Lu,Xuecai Tan,and Heyou Han*.“Novel Porphyrin Zr Metal−Organic Framework (PCN-224)-Based Ultrastable Electro-chemiluminescence System for PEDV Sensing”.Anal,Chem.2021,93,2090-2096. Yang Wu, Zhiyong Song, Guiyun Deng, Kai Jiang, Huajuan Wang, Xueji Zhang,*and Heyou Han*.“Gastric Acid Powered Nanomotors Release Antibiotics for In Vivo Treatment of Helicobacter pylori Infection”.Small 2021, 2006877. kai Zhang,Hongyang Li,Wenjing Wang,Jinxuan Gao*,Ning Gan*,and Heyou Han*.“Application of Multiplexed Aptasensors in Food Contaminants Detection”ACS Sens.2020. doi: 10.1021/acssensors.0c01740 Kai Cai, Weiyun Zhang, Mohamed F. Foda, Xuyu Li, Jin Zhang, Yeteng Zhong,Huageng Liang,* Huiqiao Li, Heyou Han* and Tianyou Zhai*.”Miniature Hollow Gold Nanorods with Enhanced Effect for In Vivo Photoacoustic Imaging in the NIR-II Window” Small 2002748 Zhaoyu Ma, Yifan Zhang, Jin Zhang, Weiyun Zhang, Mohamed F. Foda, Xinxin Dai and Heyou Han*.”Ultrasmall Peptide-Coated Platinum Nanoparticles for Precise NIR-II Photothermal Therapy by Mitochondrial Targeting.“ ACS Appl. Mater. Interfaces 2020,