Hopfner, Karl-Peter - Ludwig-Maximilians-Universität München

个人简介

Studied biology at Regensburg and St.Louis 1997 PhD, Max-Planck-Institute of Structural Biology, Martinsried 1998-2001 Postdoctoral research at Scripps Research Institute, USA 2001-2004 Professor (C3, tenure-track) of Biochemistry, LMU Munich 2005

研究领域

DNA repair and genome maintenance Repair of DNA damage in chromatin RNA maintenance

近期论文

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Molecular architecture of the HerA-NurA DNA double-strand break resection complex. Byrne RT, Schuller JM, Unverdorben P, Förster F, Hopfner KP. FEBS Lett. 2014 Dec 20;588(24):4637-44. doi: 10.1016/j.febslet.2014.10.035. Epub 2014 Nov 11. c-di-AMP recognition by Styphylococcus aureus PstA Müller M., Hopfner KP and Witte G FEBS Lett. 2014 Nov 27 pii: S0014-5793(14)00827-8. doi: 10.1016/j.febslet.2014.11.022. [Epub ahead of print] Structure of the Rad50 DNA double-strand break repair protein in complex with DNA. Rojowska A, Lammens K, Seifert FU, Direnberger C, Feldmann H, Hopfner KP. EMBO J. 2014 Oct 27. ATP puts the brake on DNA double-strand break repair: A new study shows that ATP switches the Mre11-Rad50-Nbs1 repair factor between signaling and processing of DNA ends. Hopfner KP. Bioessays. 2014 Sep 11. doi: 10.1002/bies.201400102 RIG-I Holds the CARDs in a Game of Self versus Nonself. Hopfner KP. Mol Cell. 2014 Aug 21;55(4):505-7. doi: 10.1016/j.molcel.2014.08.009. T cell-recruiting triplebody 19-3-19 mediates serial lysis of malignant B-lymphoid cells by a single T cell. Roskopf CC, Schiller CB, Braciak TA, Kobold S, Schubert IA, Fey GH, Hopfner KP, Oduncu FS. Oncotarget. 2014 Aug 30;5(15):6466-83. OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids. Hornung V, Hartmann R, Ablasser A, Hopfner KP. Nat Rev Immunol. 2014 Aug;14(8):521-8. doi: 10.1038/nri3719. Epub 2014 Jul 18. Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia. Gockel I, Becker J, Wouters MM, Niebisch S, Gockel HR, Hess T, Ramonet D, Zimmermann J, Vigo AG, Trynka G, de León AR, de la Serna JP, Urcelay E, Kumar V, Franke L, Westra HJ, Drescher D, Kneist W, Marquardt JU, Galle PR, Mattheisen M, Annese V, Latiano A, Fumagalli U, Laghi L, Cuomo R, Sarnelli G, Müller M, Eckardt AJ, Tack J, Hoffmann P, Herms S, Mangold E, Heilmann S, Kiesslich R, von Rahden BH, Allescher HD, Schulz HG, Wijmenga C, Heneka MT, Lang H, Hopfner KP, Nöthen MM, Boeckxstaens GE, de Bakker PI, Knapp M, Schumacher J. Nat Genet. 2014 Aug;46(8):901-4. doi: 10.1038/ng.3029. Epub 2014 Jul 6. Structural Studies of DNA End Detection and Resection in Homologous Recombination. Schiller CB, Seifert FU, Linke-Winnebeck C, Hopfner KP. Cold Spring Harb Perspect Biol. 2014 Jul 31. pii: a017962. doi: 10.1101/cshperspect.a017962. Crystallization of Mouse RIG-I ATPase Domain: In Situ Proteolysis. Civril F, Hopfner KP. Methods Mol Biol. 2014;1169:27-35. doi: 10.1007/978-1-4939-0882-0_3. Single-molecule choreography between telomere proteins and G quadruplexes. Hopfner KP. Structure. 2014 Jun 10;22(6):801-2. doi: 10.1016/j.str.2014.05.011. Crystal and solution structure of the human RIG-I SF2 domain T. Deimling, S. Cui, K. Lammens, K.-P. Hopfner and G. Witte Acta Cryst. (2014). F70, 1027-1031 Editorial overview: Theory and simulation: Macromolecular machines. Hopfner KP, Smith TJ. Curr Opin Struct Biol. 2014 May 12. pii: S0959-440X(14)00045-1. doi: 10.1016/j.sbi.2014.04.005. [Epub ahead of print] Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1β production. Roth S, Rottach A, Lotz-Havla AS, Laux V, Muschaweckh A, Gersting SW, Muntau AC, Hopfner KP, Jin L, Vanness K, Petrini JH, Drexler I, Leonhardt H, Ruland J. Nat Immunol. 2014 Apr 28. In Vivo Ligands of MDA5 and RIG-I in Measles Virus-Infected Cells. Runge S, Sparrer KM, Lässig C, Hembach K, Baum A, García-Sastre A, Söding J, Conzelmann KK, Hopfner KP. PLoS Pathog. 2014 Apr 17;10(4):e1004081. Activating FLT3 mutants show distinct gain-of-function phenotypes in vitro and a characteristic signaling pathway profile associated with prognosis in acute myeloid leukemia. Janke H, Pastore F, Schumacher D, Herold T, Hopfner KP, Schneider S, Berdel WE, Büchner T, Woermann BJ, Subklewe M, Bohlander SK, Hiddemann W, Spiekermann K, Polzer H. PLoS One. 2014 Mar 7;9(3):e89560. Crosstalk between the cGAS DNA Sensor and Beclin-1 Autophagy Protein Shapes Innate Antimicrobial Immune Responses. Liang Q, Seo GJ, Choi YJ, Kwak MJ, Ge J, Rodgers MA, Shi M, Leslie BJ, Hopfner KP, Ha T, Oh BH, Jung JU. Cell Host Microbe. 2014 Feb 12;15(2):228-38. doi: 10.1016/j.chom.2014.01.009. NK cells from an AML patient have recovered in remission and reached comparable cytolytic activity to that of a healthy monozygotic twin mediated by the single-chain triplebody SPM-2. Braciak TA, Wildenhain S, Roskopf CC, Schubert IA, Fey GH, Jacob U, Hopfner KP, Oduncu FS. J Transl Med. 2013 Nov 16;11(1):289. [Epub ahead of print] Structure and Subunit Topology of the INO80 Chromatin Remodeler and Its Nucleosome Complex Tosi A, Haas C, Herzog F, Gilmozzi A, Berninghausen O, Ungewickell C, Gerhold CB, Lakomek K, Aebersold R, Beckmann R, Hopfner KP Cell, Volume 154, Issue 6, 1207-1219, 12 September 2013 Structural Analysis of Phenothiazine Derivatives as Allosteric Inhibitors of the MALT1 Paracaspase. Schlauderer F, Lammens K, Nagel D, Vincendeau M, Eitelhuber AC, Verhelst SH, Kling D, Chrusciel A, Ruland J, Krappmann D, Hopfner KP. Angew Chem Int Ed Engl. 2013 Aug 14. doi: 10.1002/anie.201304290.