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Zupanic A, Meplan C, Huguenin GVB, Hesketh JE, Shanley DP. Modeling and gene knockdown to assess the contribution of nonsense-mediated decay, premature termination, and selenocysteine insertion to the selenoprotein hierarchy. RNA 2016, 22(7), 1076-1084. Méplan C, Johnson IT, Polley ACJ, Cockell S, Bradburn DM, Commane DM, Arasaradnam RP, Mulholland F, Zupanic A, Mathers JC, Hesketh J. Transcriptomics and proteomics show that selenium affects inflammation, cytoskeleton, and cancer pathways in human rectal biopsies. The FASEB Journal 2016, 30(8), 2812-2825. Mistry HD, Gill CA, Kurlak LO, Seed PT, Hesketh JE, Meplan C, Schomburg L, Chappell LC, Morgan L, Poston L, SCOPE Consortium. Association between maternal micronutrient status, oxidative stress, and common genetic variants in antioxidant enzymes at 15 weeks' gestation in nulliparous women who subsequently develop preeclampsia. Free Radical Biology and Medicine 2015, 78, 147-155. Hughes DJ, Fedirko V, Jones JS, Meplan C, Schomburg L, Hybsier S, Riboli E, Hesketh JE, Jenab M, EPIC Grp. Association of selenoprotein and selenium pathway gene variation with colorectal cancer risk and modification by selenium status. In: European Cancer Congress 2015. 2015, Vienna, Austria: Elsevier. Zupanic A, Méplan C, Grellscheid SN, Mathers JC, Kirkwood TBL, Hesketh J, Shanley D. Detecting translational regulation by change point analysis of ribosome profiling data sets. RNA 2014, 20(10), 1507-1518. Méplan C, Hesketh J. Selenium and cancer: a story that should not be forgotten-insights from genomics. In: Vincenzo Zappia, Salvatore Panico, Gian Luigi Russo, Alfredo Budillon, Fulvio Della Ragione, ed. Advances in Nutrition and Cancer. Berlin: Springer-Verlag, 2014, pp.145-166. Hughes DJ, Fedirko V, Jenab M, Schomburg L, Méplan C, Freisling H, Bueno-de-Mesquita HB, Hybsier S, Becker NP, Czuban M, Tjønneland A, Outzen M, Boutron-Ruault MC, Racine A, Bastide N, Kühn T, Kaaks R, Trichopoulos D, Trichopoulou A, Lagiou P, Panico S, Peeters PH, Weiderpass E, Skeie G, Dagrun E, Chirlaque MD, Sánchez MJ, Ardanaz E, Ljuslinder I, Wennberg M, Bradbury KE, Vineis P, Naccarati A, Palli D, Boeing H, Overvad K, Dorronsoro M, Jakszyn P, Cross AJ, Quirós JR, Stepien M, Kong SY, Duarte-Salles T, Riboli E, Hesketh JE. Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort. International Journal of Cancer 2014. Méplan C, Dragstead LO, Ravn-Haren G, Tjønneland A, Vogel U, Hesketh J. Association between Polymorphisms in Glutathione Peroxidase and Selenoprotein P Genes, Glutathione Peroxidase Activity, HRT Use and Breast Cancer Risk. PLoS ONE 2013, 8(9), e73316. Hughes DJ, Jenab M, Meplan C, Schomburg L, Prehn J, Hesketh JE. Colorectal Cancer Risk - the Influence of Selenoprotein Gene Variants and Blood Selenium Status. In: 22nd Biennial Congress of the European Association for Cancer Research. 2012, Barcelona, Spain: Pergamon. Gong G, Meplan C, Gautrey H, Hall J, Hesketh JE. Differential effects of selenium and knock-down of glutathione peroxidases on TNF alpha and flagellin inflammatory responses in gut epithelial cells. Genes & Nutrition 2012, 7(2), 167-178. Méplan C, Rohrmann S, Steinbrecher A, Schomburg L, Jansen E, Linseisen J, Hesketh J. Polymorphisms in Thioredoxin Reductase and Selenoprotein K Genes and Selenium Status Modulate Risk of Prostate Cancer. PLoS One 2012, 7(11), e48709. Méplan C, Hesketh J. The influence of selenium and selenoprotein gene variants on colorectal cancer risk. Mutagenesis 2012, 27, 117-186. Steinbrecher A, Méplan C, Hesketh J, Schomburg L, Endermann T, Jansen E, Åkesson B, Rohrmann S, Linseisen J. Effects of selenium status and polymorphisms in selenoprotein genes on prostate cancer risk in a prospective study of European men. Cancer Epidemiology Biomarkers and Prevention 2010, 19(11), 2958-2968. Meplan C, Hughes DJ, Pardini B, Naccarati A, Soucek P, Vodickova L, Hlavata I, Vrana D, Vodicka P, Hesketh JE. Genetic variants in selenoprotein genes increase risk of colorectal cancer. Carcinogenesis 2010, 31(6), 1074-1079. Mathers JC, Meplan C, Hesketh JE. Polymorphisms Affecting Trace Element Bioavailability. International Journal for Vitamin and Nutrition Research 2010, 80(4-5), 314-318. van Ommen B, El-Sohemy A, Hesketh J, Kaput J, Fenech M, Evelo CT, McArdle HJ, Bouwman J, Lietz G, Mathers JC, Fairweather-Tait S, van Kranen H, Elliott R, Wopereis S, Ferguson LR, Meplan C, Perozzi G, Allen L, Rivero D, Micronutrient Genomics Project Wor. The Micronutrient Genomics Project: a community-driven knowledge base for micronutrient research. Genes & Nutrition 2010, 5(4), 285-296. Kipp A, Banning A, van Schothorst EM, Meplan C, Schomburg L, Evelo C, Coort S, Gaj S, Keijer J, Hesketh J, Brigelius Flohe R. Four selenoproteins, protein biosynthesis, and Wnt signalling are particularly sensitive to limited selenium intake in mouse colon. Molecular Nutrition & Food Research 2009, 53(12), 1561-1572. Meplan C, Nicol F, Burtle BT, Crosley LK, Arthur JR, Mathers JC, Hesketh JE. Relative Abundance of Selenoprotein P Isoforms in Human Plasma Depends on Genotype, Se Intake, and Cancer Status. Antioxidants & Redox Signaling 2009, 11(11), 2631-2640. Leung WC, Hessel S, Méplan C, Flint J, Oberhauser V, Tourniaire F, Hesketh JE, von Lintig J, Lietz G. Two common single nucleotide polymorphisms in the gene encoding β-carotene 15,15′-monoxygenase alter β-carotene metabolism in female volunteers. FASEB Journal 2009, 23(4), 1041-1053. Meplan C, Crosley LK, Nicol F, Horgan GW, Mathers JC, Arthur JR, Hesketh JE. Functional effects of a common single-nucleotide polymorphism (GPX4c718t) in the glutathione peroxidase 4 gene: Interaction with sex. American Journal of Clinical Nutrition 2008, 87(4), 1019-1027. Pagmantidis V, Meplan C, Van Schothorst EM, Keijer J, Hesketh JE. Supplementation of healthy volunteers with nutritionally relevant amounts of selenium increases the expression of lymphocyte protein biosynthesis genes. American Journal of Clinical Nutrition 2008, 87(1), 181-189. Crosley LK, Meplan C, Nicol F, Rundlof AK, Arner ESJ, Hesketh JE, Arthur JR. Differential regulation of expression of cytosolic and mitochondrial thioredoxin reductase in rat liver and kidney. Archives of Biochemistry and Biophysics 2007, 459(2), 178-188. Meplan C, Crosley LK, Nicol F, Beckett GJ, Howie AF, Hill KE, Horgan G, Mathers JC, Arthur JR, Hesketh JE. Genetic polymorphisms in the human selenoprotein P gene determine the response of selenoprotein markers to selenium supplementation in a gender-specific manner (the SELGEN study). FASEB Journal 2007, 21(12), 3063-3074. Meplan C, Crosley K, Nicol F, Beckett GJ, Arthur JR, Mathers JC, Hesketh JE. A polymorphism in the coding region of human selenoprotein P gene influences the response to selenium supplementation in healthy volunteers. In: Scientific Meeting of the Nutrition Society. 2006, Aberdeen, UK: Proceedings of the Nutrition Society: Cambridge University Press. Meplan C, Crosley K, Nicol F, Arthur JR, Mathers JC, Hesketh JE. Influences of gender and genetic variation in the 3 ' untranslated region of the glutathione peroxidise 4 gene on the response to selenium supplementation in healthy volunteers. In: Proceedings of the Nutrition Society. 2006, Aberdeen, Scotland: Cambridge University Press.