Knight, Andrew - Newcastle University - School of Biomedical Sciences

个人简介

2003-2005 Wellcome Trust Teaching Fellow. Institute for Immunology and Infection Research (IIIR), School of Biological Sciences, Ashworth Laboratories, University of Edinburgh, Edinburgh 1999-2003 Wellcome Trust Career Development Fellow Institute for Immunology and Infection Research (IIIR), School of Biological Sciences, Ashworth Laboratories, University of Edinburgh, Edinburgh 1994–1999 Senior Post-Doctoral Research Assistant, Department of Biochemistry, Medical Sciences Institute, University of Dundee, Dundee 1988-1993 Scientific Officer (part-time Ph.D. student) Transplantation Biology Section, Clinical Research Centre, Harrow, Middlesex 1986 Junior Research Technician, Ludwig Institute for Cancer Research, Haddow Laboratories, Sutton, Surrey

研究领域

For the initiation of the CD4+ T cell response, native protein antigens (Ag.) must be captured, intra-cellularly processed, complexed with molecules encoded by the major histocompatibility complex (MHC) class II region and re-expressed on the cell surface of antigen presenting cells (APC).

近期论文

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Knight AM. B-cell acquisition of antigen: Sensing the surface. European Journal of Immunology 2015, 45(6), 1600-1604. Ciechomska M, Wilson CL, Floudas A, Hui W, Rowan AD, van Eden W, Robinson JH, Knight AM. Antigen-specific B lymphocytes acquire proteoglycan aggrecan from cartilage extracellular matrix resulting in antigen presentation and CD4+ T-cell activation. Immunology 2014, 141(1), 70-78. Floudas A, Griffiths L, Jones D, Knight AM, Palmer JM. Altered B cell populations and cytokine production in primary biliary cirrhosis. In: BSI Congress 2013: Annual Congress of the British-Society-for-Immunology. 2013, Liverpool, England: Wiley-Blackwell Publishing Ltd. Wilson CL, Hine DW, Pradipta A, Pearson JP, van Eden W, Robinson JH, Knight AM. Presentation of the candidate rheumatoid arthritis autoantigen aggrecan by antigen-specific B cells induces enhanced CD4+T helper type 1 subset differentiation. Immunology 2012, 135(4), 344-354. Ciechomska M, Lennard TWJ, Kirby JA, Knight AM. B lymphocytes acquire and present intracellular antigens that have relocated to the surface of apoptotic target cells. European Journal of Immunology 2011, 41(7), 1850-1861. Hoefer MM, Aichem A, Knight AM, Illges H. Modulation of murine complement receptor type 2 (CR2/CD21) ectodomain shedding by its cytoplasmic domain. Molecular Immunology 2008, 45(8), 2127-2137. Knight AM. Regulated release of B cell-derived exosomes: Do differences in exosome release provide insight into different APC function for B cells and DC?. European Journal of Immunology 2008, 38(5), 1186-1189. Brown SL, Barrault DV, Phythian-Adams A, Knight AM. Lack of induced co-stimulation as a result of complement receptor 2 (CR2) ligation on mouse splenic B cells. International Immunology 2006, 18(1), 69-78. Barrault DV, Steward M, Cox VF, Smith RAG, Knight AM. Efficient production of complement (C3d)3 fusion proteins using the baculovirus expression vector system. Journal of Immunological Methods 2005, 304(1-2), 158-173. Barrault DV, Knight AM. Distinct Sequences in the Cytoplasmic Domain of Complement Receptor 2 Are Involved in Antigen Internalization and Presentation. Journal of Immunology 2004, 172(6), 3509-3517. Brooks K, Knight AM. Lowering the affinity between antigen and the B cell receptor can enhance antigen presentation. European Journal of Immunology 2004, 34(3), 837-843. A. M. Knight,J. M. Lucocq,A. R. Prescott,S. Ponnambalam,C. Watts. Antigen endocytosis and presentation mediated by human membrane IgG1 in the absence of the Ig(alpha)/Ig(beta) dimer. Embo J 1997, 16(13), 3842-50. E. Simpson,P. J. Dyson,A. M. Knight,P. J. Robinson,J. I. Elliott,D. M. Altmann. T-cell receptor repertoire selection by mouse mammary tumor viruses and MHC molecules. Immunol Rev 1993, 131, 93-115. A. M. Knight,G. B. Harrison,R. J. Pease,P. J. Robinson,P. J. Dyson. Biochemical analysis of the mouse mammary tumor virus long terminal repeat product. Evidence for the molecular structure of an endogenous superantigen. Eur J Immunol 1992, 22(3), 879-82. K. Tomonari,S. Fairchild,O. A. Rosenwasser,P. J. Robinson,A. M. Knight,P. J. Dyson. Endogenous ligands selecting T cells expressing particular V beta elements. Int Rev Immunol 1992, 8(4), 289-309. M. McDuffie,D. Schweiger,B. Reitz,A. Ostrowska,A. M. Knight,P. J. Dyson. I-E-independent deletion of V beta 17a+ T cells by Mtv-3 from the nonobese diabetic mouse. J Immunol 1992, 148(7), 2097-102. P. J. Dyson,C. de Smet,A. M. Knight,D. Simon-Chazottes,J. L. Guenet,T. Boon. Mapping of the genes encoding tum- transplantation antigens P91A, P35B, and P198. Immunogenetics 1992, 35(5), 316-23. G. A. Fowlis,S. Adelman,A. M. Knight,E. Simpson. PCR-analyzed microsatellites of the mouse genome--additional polymorphisms among ten inbred mouse strains. Mamm Genome 1992, 3(4), 192-6. C. M. Hearne,M. A. McAleer,J. M. Love,T. J. Aitman,R. J. Cornall,S. Ghosh,A. M. Knight,J. B. Prins,J. A. Todd. Additional microsatellite markers for mouse genome mapping. Mamm Genome 1991, 1(4), 273-82. P. J. Dyson,A. M. Knight,S. Fairchild,E. Simpson,K. Tomonari. Genes encoding ligands for deletion of V beta 11 T cells cosegregate with mammary tumour virus genomes. Nature 1991, 349(6309), 531-2. J. A. Todd,T. J. Aitman,R. J. Cornall,S. Ghosh,J. R. Hall,C. M. Hearne,A. M. Knight,J. M. Love,M. A. McAleer,J. B. Prins,et al. Genetic analysis of autoimmune type 1 diabetes mellitus in mice. Nature 1991, 351(6327), 542-7. A. M. Knight,P. J. Dyson. Detection of DNA polymorphisms between two inbred mouse strains-- limitations of restriction fragment length polymorphisms (RFLPs). Mol Cell Probes 1990, 4(6), 497-504. J. M. Love,A. M. Knight,M. A. McAleer,J. A. Todd. Towards construction of a high resolution map of the mouse genome using PCR-analysed microsatellites. Nucleic Acids Res 1990, 18(14), 4123-30.