Halic, Mario - Ludwig-Maximilians-Universität München

个人简介

1994 - 1999 Diplom at University of Zagreb, Croatia 2001 - 2005 Ph. D. at Humboldt University Berlin, Germany 2005 - 2007 Postdoctoral fellow at Humboldt University Berlin and University of Munich, Germany 2007 - 2011 Postdoctoral fellow at Harvar

研究领域

Small RNA mediated regulation of genome expression X-ray crystallography and electron microscopy of multicomponent complexes involved in RNAi Molecular systems biology of gene regulation

近期论文

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Marasovic M, Zocco M, Halic M. Argonaute and Triman generate dicer-independent priRNAs and mature siRNAs to initiate heterochromatin formation. Mol Cell. 2013 Oct 24;52(2):173-83. Gerace E, Halic M, Moazed D The Methyltransferase Activity of Clr4Suv39h triggers RNAi Independently of Histone H3K9 Methylation. Mol Cell. 2010 Aug 13;39(3):360-72. Halic M and Moazed D Dicer-Independent priRNAs and Argonaute Trigger RNAi and Heterochromatin Formation Cell. 2010 Feb 19;140(4):504-516. Bhushan S, Gartmann M, Halic M, Armache JP, Jarasch A, Mielke T, Berninghausen O, Wilson DN, Beckmann R α-Helical nascent polypeptide chains visualized within distinct regions of the ribosomal exit tunnel Nat Struct Mol Biol. 2010; Published online: 7 February 2010 | doi:10.1038/nsmb.1756. Halic M, Moazed D. 22G-RNAs in transposon silencing and centromere function. Mol Cell. 2009 Oct 23;36(2):170-1. Halic M, Moazed D. Transposon silencing by piRNAs. Cell. 2009 Sep 18;138(6):1058-60. Halic M, Blau M, Becker T, Mielke T, Pool MR, Wild K, Sinning I, Beckmann R Following the Signal Sequence from the Ribosomal Tunnel Exit to Signal Recognition Particle Nature. 2006 Nov 23;444(7118):507-11. Andersen CB, Becker T, Blau M, Anand M, Halic M, Balar B, Mielke T, Boesen T, Pedersen JS, Spahn CM, Kinzy TG, Andersen GR, Beckmann R. Structure of eEF3 and the mechanism of transfer RNA release from the E-site. Nature. 2006 Oct 12;443(7112):663-8. Halic M, Gartmann M, Schlenker O, Mielke T, Pool MR, Sinning I, Beckmann R Signal recognition particle receptor exposes the ribosomal translocon binding site. Science. 2006 May 5;312(5774):745-7. Halic M, Becker T, Frank J, Spahn CM, Beckmann R. Localization and dynamic behavior of ribosomal protein L30e. Nat Struct Mol Biol. 2005 May;12(5):467-8. Epub 2005 May 1. Halic M, Beckmann R. The signal recognition particle and its interactions during protein targeting. Curr Opin Struct Biol. 2005 Feb;15(1):116-25. Review. Wild K*, Halic M*, Sinning I, Beckmann R. SRP meets the ribosome. Nat Struct Mol Biol. 2004 Nov;11(11):1049-53. Review. * Both authors contributed equally Halic M, Becker T, Pool MR, Spahn CM, Grassucci RA, Frank J, Beckmann R. Structure of the signal recognition particle interacting with the elongation-arrested ribosome. Nature. 2004 Feb 26;427(6977):808-14.