个人简介
Studied Biochemistry at the University of Tübingen and the University of Washington, Seattle / USA
2002 PhD at the Swiss Institute of Experimental Cancer Research (ISREC), Lausanne/Switzerland
2002-2003 Postdoctoral research at ISREC, Lausanne/Switzer
研究领域
Biogenesis of microRNAs and RISC complexes
Biological relevance of microRNA-mediated regulation
Transport and sub-cellular localization of microRNA precursors
近期论文
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Böttcher R, Hollmann M, Merk K, Nitschko V, Obermaier C, Philippou-Massier J, Wieland I, Gaul U, Förstemann K (2014). Efficient chromosomal gene modification with CRISPR/cas9 and PCR-based homologous recombination donors in cultured Drosophila cells. Nucleic Acids Res. 2014 Apr 19.
Mirkovic-Hösle M, Förstemann K (2014). Transposon defense by endo-siRNAs, piRNAs and somatic pilRNAs in Drosophila: contributions of Loqs-PD and R2D2. PLoS One. 2014 Jan 13;9(1):e84994. doi: 10.1371
Esslinger SM, Schwalb B, Helfer S, Michalik KM, Witte H, Maier KC, Martin D, Michalke B, Tresch A, Cramer P, Förstemann K. (2013): Drosophila miR-277 controls branched-chain amino acid catabolism and affects lifespan. RNA Biology
Schertel C, Rutishauser T, Förstemann K, Basler K (2012). Functional Characterization of Drosophila microRNAs by a Novel in vivo Library. Genetics [Epub ahead of Print]
Michalik K., Böttcher R., Förstemann K. (2012): A small RNA response at DNA ends in Drosophila, Nucleic Acids Research
Aumiller VA, Graebsch A, Kremmer E, Niessing, D, Förstemann K (2012). Drosophila Pur-α binds to trinucleotide-repeat containing cellular RNAs and translocates to the early oocyte. RNA Biol. 9(5), p 633
Dittmer A, Förstemann K (2012). MCMV infection of cultured mouse cells induces expression of miR-7a. J Gen Virol. 2012 Mar 21.
Helfer S, Schott J, Stoecklin G and Förstemann K (2012). AU-rich Element Mediated mRNA Decay can occur independently of the miRNA machinery in Mouse Embryonic Fibroblasts and Drosophila S2-cells. PLoS One. 2012;7(1):e28907
Hartig, JV, Förstemann, K (2011) Loqs-PD and R2D2 define independent pathways for RISC generation in Drosophila. Nucleic Acids Res., doi:10.1093/nar/gkq1324
Förstemann K (2010). Transposon defense in Drosophila somatic cells: A model for distinction of self and non-self in the genome. RNA Biol. 2010 Mar 28;7(2). (invited Review article)
Hartig JV, Esslinger S, Böttcher, R, Saito K, Förstemann K (2009). Endo-siRNAs depend on a new isoform of loquacious and target artificially introduced, high-copy sequences. EMBO J. 2009 Oct 7;28(19):2932-44.
Esslinger S, Förstemann K (2009). MicroRNAs repress mainly through mRNA decay. Angew Chem Int Ed Engl. 2009;48(5):853-5. (invited Review article)
Shah C, Förstemann K (2008). Monitoring miRNA-mediated silencing in Drosophila melanogaster S2-cells. Biochim Biophys Acta. 2008 Nov;1779(11):766-72.
Aumiller V, Förstemann K (2008). Roles of microRNAs beyond development - Metabolism and neural plasticity. Biochim Biophys Acta. 2008 Nov;1779(11):692-6.(invited Review article)
Hartig JV, Tomari Y, Förstemann K (2007). piRNAs--the ancient hunters of genome invaders. Genes Dev. 21(14):1707-13.(invited Review article)http://www.ncbi.nlm.nih.gov/pubmed/17639076
Förstemann K*, Horwich MD*, Wee L, Tomari Y, Zamore PD. (2007). Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1. Cell 130(2):287-97
Förstemann K. et al., 2005: Normal microRNA Maturation and Germ-Line Stem Cell Maintenance Requires Loquacious, a Double-Stranded RNA-Binding Domain Protein. PLoS Biol. 3(7):e236
Förstemann K., Lingner J., 2005: Telomerase limits the extent of base pairing between template RNA and telomeric DNA. EMBO Rep. 6(4):361-6.
Förstemann K., Zaug A.J., Cech T.R., Lingner J., 2003: Yeast telomerase is specialized for C/A-rich RNA templates. Nucleic Acids Res. 31(6):1646-55.
Kelleher C, Teixeira MT, Förstemann K, Lingner J, 2002: Telomerase: biochemical considerations for enzyme and substrate. Trends Biochem Sci. 27(11):572-9.
Teixeira M.T., Förstemann K., Gasser S.M., Lingner J., 2002: Intracellular trafficking of yeast telomerase components. EMBO Rep. 3(7):652-9.
Förstemann K, Lingner J., (2001). Molecular basis for telomere repeat divergence in budding yeast. Mol Cell Biol. 21(21), 7277-86
Förstemann K, Hoss M, Lingner J., (2000). Telomerase-dependent repeat divergence at the 3' ends of yeast telomeres. Nucleic Acids Res. 28(14), 2690-4
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