Carell, Thomas - Ludwig-Maximilians-Universität München

个人简介

Studied chemistry at Münster 1993 PhD, Max-Planck-Institute for Medical Research, Heidelberg 1993-1995 Postdoctoral research, Massachusetts Institute of Technology, USA 1998 Habilitation, ETH Zürich 1999-2000 Privatdozent, ETH Zürich 2000-2003 P

研究领域

DNA materials Repair of DNA damage RNA modifications

近期论文

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L. Penter, B. Maier, U. Frede, B. Hackner, T. Carell, C. Hagemeier, M. Truss Target Oncol. 2015 , 10.1007/s11523-014-0354-5 A rapid screening system evaluates novel inhibitors of DNA methylation and suggests F-box proteins as potential therapeutic targets for high-risk neuroblastoma M. Su, M. Tomas–Gamasa, T. Carell Chem. Sci. 2015, 6, 632-638 DNA based multi-copper ions assembly using combined pyrazole and salen ligandosides K. Brunner, J. Harder, T. Halbach, J. Willibald, F. Spada, F. Gnerlich, K. Sparrer, A. Beil, L. Möckl, C. Bräuchle, K-K Conzelmann, T. Carell Angew. Chem. Int. Ed. 2014, 53, 1-5 Cell-Penetrating and Neurotargeting Dendritic siRNA Nanostructures M. Tomas–Gamasa, S. Serdjukow, M. Su, M. Müller, T. Carell Angew. Chem. Int. Ed. 2014, 54, 796-800 "Post-It" Type Connected DNA Created with a Reversible Covalent Cross-Link O. Ziv, A. Zeisel, N. Mirlas-Neisberg, U. Swain, R. Nevo, N. Ben-Chetrit, M. Paola Martelli, R. Rossi, S.n Schiesser, C. E. Canman, T. Carell, N. E. Geacintov, B. Falini, E. Domany, Z. Livneh Nat. Commun. 2014, 5:5437 Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin. A. Benjdia, K. Heil, A. Winkler, T. Carell, I. Schlichting. Chem. Commun. 2014, 50, 14201-14204 Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase D. B. Bucher, A. Schlueter, T. Carell, W. Zinth Angew. Chem. Int. Ed. 2014, 53, 11366-11369 Watson-Crick Base Pairing Controls Excited-State Decay in Natural DNA A. Biela, F. Coste, F. Culard, M. Guerin, S. Goffinont, K. Gasteiger, J. Cieśla, A. Winczura, Z. Kazimierczuk, D. Gasparutto, T. Carell, B. Tudek, B. Castaing Nucl. Acids Res. 2014, 42, 10748-10761 Zinc finger oxidation of Fpg/Nei DNA glycosylases by 2-thioxanthine: biochemical and X-ray structural characterization K. Sadeghian, D. Flaig, I. D. Blank, S. Schneider, R. Strasser, D. Stathis, M. Winnacker, T. Carell, C. Ochsenfeld Angew. Chem. Int. Ed. 2014, 53, 10044-10048 Ribose-Protonated DNA Base Excision Repair: A Combined Theoretical and Experimental Study L. I. Kroeze, M. G. Aslanyan, A. van Rooij, T. N. Koorenhof-Scheele, M. Massop, T. Carell, J. B. Boezeman, J.-P. Marie, C. J. M. Halkes, T. de Witte, G. Huls, S. Suciu, R. A. Wevers, B. A. van der Reijden, J. H. Jansen Blood 2014, 124, 1110-1118 Characterization of acute myeloid leukemia based on levels of global hydroxymethylation T. Pfaffeneder, F. Spada, M. Wagner, C. Brandmayr, S. K. Laube, D. Eisen, M. Truss, J. Steinbacher, B. Hackner, O. Kotljarova, D. Schuermann, S. Michalakis, O. Kosmatchev, S. Schiesser, B. Steigenberger, N. Raddaoui, G. Kashiwazaki, U. Müller, C. G. Spruijt, M. Vermeulen, H. Leonhardt, P. Schär, M. Müller & T. Carell Nat. Chem. Biol. 2014, 10, 574-581 Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA N. Kitsera, K. Gasteiger, B. Lühnsdorf, J. Allgayer, B. Epe, T. Carell, A. Khobta PLOS One 2014, 9 (4), e94405 Cockayne Syndrome: Varied Requirement of Transcription-Coupled Nucleotide Excision Repair for the Removal of Three Structurally Different Adducts from Transcribed DNA S. Serdjukow, F. Kink, B. Steigenberger, M. Tomas–Gamasa, T. Carell Chem. Commun. 2014, 50, 1861-1863 Synthesis of γ-labeled nucleoside 5'-triphosphates using click chemistry D.B. Bucher, B.M. Pilles, T. Carell, W. Zinth Proc. Natl. Acad. Sci. U.S.A. 2014, 111 (12), 4369-4374 Charge separation and charge delocalization identified in long-living states of photoexcited DNA P. Bashtrykov, A. Rajavelu, B. Hackner, S. Ragozin, T. Carell, A. Jeltsch ChemBioChem. 2014, 15, 743-8 Targeted Mutagenesis Results in an Activation of DNA Methyltransferase 1 and Confirms an Autoinhibitory Role of its RFTS Domain D.B. Bucher, B.M. Pilles, T. Pfaffeneder, T. Carell, W. Zinth Chemphyschem. 2014, 15, 420-3 Fingerprinting DNA oxidation processes: IR characterization of the 5-methyl-2´-deoxycytidine radical cation C.N. Buechner, K. Heil, G. Michels, T. Carell, C. Kisker, I. Tessmer J Biol Chem. 2014, 289, 3613-3624 Strand specific recognition of DNA damages by XPD provides insights into Nucleotide Excision Repair substrate versatility M. Su, M. Tomás-Gamasa, S. Serdjukow, P. Mayer, T. Carell Chem Commun (Camb). 2014, 50, 409-411 Synthesis and properties of a Cu(II) complexing pyrazole ligandoside in DNA A.S. Schröder, J. Steinbacher, B. Steigenberger, F.A. Gnerlich, S. Schiesser, T. Pfaffeneder, T. Carell Angew. Chem. Int. Ed. 2014, 53, 315-8 (selected as Hot-Paper) Synthesis of a DNA Promoter Segment Containing All Four Epigenetic Nucleosides: 5-Methyl-, 5-Hydroxymethyl-, 5-Formyl-, and 5-Carboxy-2’-Deoxycytidine A.C. Kneuttinger, G. Kashiwazaki, S. Prill, K. Heil, M. Müller, T. Carell Photochem Photobiol. 2014, 90, 1-14 Formation and Direct Repair of UV-induced Dimeric DNA Pyrimidine Lesions