Bracher, Franz - Ludwig-Maximilians-Universität München

个人简介

Studied pharmacy at the LMU Munich 1986 PhD in Pharmaceutical Chemistry, LMU Munich 1986-1987 Postdoctoral Researcher at the Department of Organic Chemistry, University of Geneve/Switzerland 1991 Habilitation, University of Marburg 1992-1997 C3 Pr

研究领域

Natural product chemistry (synthesis, biological activities) Inhibitors of ergosterol and cholesterol biosynthesis as new drugs Development of new, selective kinase inhibitors

近期论文

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A. Plodek, F. Bracher: A divergent approach to the total synthesis of the marine pyridoacridine alkaloid eilatin and its synthetic isomer isoeilatin. Tetrahedron Lett., 56, 1445-1447 (2015) J. Krauß, M. Hornacek, C. Müller, V. Staudacher, M. Stadler, F. Bracher: Synthesis and antifungal evaluation of novel N-alkyl tetra- and perhydroquinoline derivatives. Sci. Pharm., accepted (2014) A. Plodek, M. König, F. Bracher: Synthesis of the azaoxoaporphine alkaloid sampangine and ascididemin-type pyridoacridines via TMPMgCl*LiCl mediated ring closure. Eur. J. Org. Chem., 1302-1308 (2015) B. Strödke, A. P. Gehring, F. Bracher: Synthesis of desaza analogues of annomontine and canthin-4-one alkaloids, Arch. Pharm. Pharm. Med. Chem., 348, 125-131 (2015) M. Giera, C. Müller, F. Bracher: Analysis and experimental inhibition of distal cholesterol biosynthesis, Chromatographia, published online nov. (2014) J. Herms, K. Honarnejad, A. Daschner, A. Gehring, A. Szybinska, A. Giese, J. Kuznicki, F. Bracher: Identification of tetrahydrocarbazoles as novel multifactorial drug candidates for treatment of Alzheimer's disease, Translational Psychiatry, 4, e489 (2014) C.-C. Chen, M. Keller, M. Heß, R. Schiffmann, N. Urban, A. Wolfgardt, M. Schaefer, F. Bracher, M. Biel, C. Wahl-Schott, C. Grimm: A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV, Nature Communications, 5:4681, (2014) B. Melzer, A. Plodek, F. Bracher: Total synthesis of the marine pyridoacridine alkaloid demethyldeoxyamphimedine, J. Org. Chem. 79, 7239-7242 (2014) C. Grimm, L. M. Holdt, C.-C. Chen, S. Hassan, C. Müller, S. Jörs, H. Cuny, S. Kissing, B. Schröder, E. Butz, B. Northoff, J. Castonguay, C. A. Luber, M. Moser, S. Spahn, R. Lüllmann-Rauch, C. Fendel, N. Klugbauer, O. Griesbeck, A. Haas, M. Mann, F. Bracher, D. Teupser, P. Saftig, M. Biel, C. Wahl-Schott: High Susceptibility to Fatty Liver Disease in Two-pore Channel 2 Deficient Mice, Nature Communications, 5:4699, (2014) S. Kern, S. Agarwal, K. Huber, A. P. Gehring, B. Strödke, T. Brügl, C. C. Wirth, L. O. Abodo, T. Dandekar, C. Doerig, R. Fischer, A. B. Tobin, M. M. Alam, F. Bracher, G. Pradel: Inhibition of the SR protein-phosphorylating CLK kinases of Plasmodium falciparum impairs blood stage replication and malaria transmission, PLoS ONE 9(9):e105732 (2014) F. Bracher, J. Krauß: Medicinal chemistry and pharmacology of antifungals, Pharmakon 2, 191-199 (2014) D.-P. Kloos, E. Gay, H. Lingeman, F. Bracher, C. Müller, O. A. Mayboroda, A. M. Deelder, W. M. A. Niessen, M. Giera: Comprehensive GC–MS analysis of fatty acids and sterols using sequential one-pot silylation: quantification and isotopologue analysis, Rapid Commun. Mass Spectrom. (2014) F. Vetter, J. Pohl, B. Pohl, F. Bracher: Analysis of cefaclor in novel chocolate-based camouflage capsules, Pharmazie 69, 455-457 (2014) C. Müller, F. Vetter, E. Richter, F. Bracher: Determination of caffeine, myosmine, and nicotine in chocolate by headspace solid-phase microextraction coupled with gas chromatography-tandem mass spectrometry, J. Food Sci. 79, T251-255 (2014) J. Krauß, E. Plesch, S. Clausen, F. Bracher: Short and efficient synthesis of alkyl- and aryl ortho-hydroxy anilides and their antibiotic activity, Sci. Pharm. 82, 501-517 (2014) A. P. Gehring, T. Tremmel, F. Bracher: One-pot conversion of 1-bromo-β-carboline and 1-bromocarbazole into pentacyclic compounds by Suzuki cross-coupling followed by spontaneous cyclization, Synthesis 46, 893-898 (2014) J. Krauß, C. Müller, J. Kießling, S. Richter, V. Staudacher, F. Bracher: Synthesis and biological evaluation of novel N-alkyl tetra- and decahydroisoquinolines: Novel antifungals that target ergosterol biosynthesis, Arch. Pharm. Pharm. Med. Chem. 347, 283-290 (2014) J. Lancelot, S. Caby, F. Dubois-Abdesselem, M. Vanderstraete, J. Trolet, G. Oliveira, F. Bracher, M. Jung, M., R. J. Pierce: Schistosoma mansoni sirtuins: characterization and potential as chemotherapeutic targets, PLOS Negl. Trop. Dis. 7, e2428 (2014) P. Veiga-Santos, L. C. Reignault, K. Huber, F. Bracher, W. de Souza, T. M. Ulisses de Carvalho: Inhibition of NAD+-dependent histone deacetylases (sirtuins) causes growth arrest and activates both apoptosis and autophagy in the pathogenic protozoan Trypanosoma cruzi, Parasitology 141, 814-825 (2014) M. Krojer, C. Müller, F. Bracher: Steroidomimetic aminomethyl spiroacetals as novel inhibitors of the enzyme Δ8,7-sterol isomerase in cholesterol biosynthesis, Arch. Pharm. Pharm. Med. Chem. 347, 108-122 (2013)