Edwards, Martin - Newcastle University

个人简介

1998-2001 PhD, University of Durham “Enhancing Resistance of Horticultural Crops Towards Vine Weevil Through Plant Genetic Engineering”. The basis of the project is to identify the major digestive proteases used by the vine weevil, and then target these with plant derived protein inhibitors which can be introduced into susceptible crops via plant genetic engineering. Awarded 2003. 1997-1998 MSc in Biomedical Sciences, University of Newcastle upon Tyne. Pass with Merit. This twelve-month course consisted of six months of lectures covering the principles of molecular genetics, protein engineering and microbiology. The second part of the course involved a laboratory based project in which I investigated the relationship between alternately spliced transcripts of the mdm2 gene and the severity of breast carcinoma, in the Department of Pathology at the Royal Victoria Infirmary. 1994-1997 BSc(Hons) in Genetics, University of Newcastle upon Tyne. Classification 2ii. This undergraduate degree course contained the usual intensive lecture courses, along with a ten week laboratory research project which gave me sound basis in many molecular biological techniques.

研究领域

Expression of novel enzymes in bioreactor systems, and optimising their expression levels Utilization of plant expression machinery as bio-factories To identify the differential regulation of plant genes in response to biotic and abiotic stress Ectopic expression of endogenous defense genes to increase a crops resistance to insect attack Identification of novel insecticidal proteins for the use in crop protection strategies Combining and comparing marker assisted breeding and traditional plant breeding strategies with GM technology

近期论文

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Guo J, Zhang H, Edwards M, Wang Z, Bai S, He K. Expression patterns of the glycogen phosphorylase gene related to larval diapause in Ostrinia furnacalis. Archives of Insect Biochemistry and Physiology 2016, (Early View). Abd-El-Halim HM, Alshukri BMH, Ahmad MS, Nakasu EYT, Awwad MH, Salama EM, Gatehouse AMR, Edwards MG. RNAi-mediated knockdown of the voltage gated sodium ion channel TcNav causes mortality in Tribolium castaneum. Scientific Reports 2016, 6, 1-9. Nakasu EY, Karamaouna F, Partsinevelos GK, Abd-El-Halim HM, Fitches EC, Pyati P, Gatehouse JA, Gatehouse AMR, Edwards MG. Sublethal effects of the insecticidal fusion protein ω-ACTX-Hv1a/GNA on the parasitoid Eulophus pennicornis via its host Lacanobia oleracea. Pest Management Science 2016, 72(3), 585-590. Lu H, Edwards M, Wang Q, Zhao H, Fu H, Huang J, Gatehouse A, Shu Q. Expression of cytochrome P450 CYP81A6 in rice: tissue specificity, protein subcellular localization, and response to herbicide application. Journal of Zhejiang University-Science B 2015, 16(2), 113-122. Lee J, Orosa B, Millyard L, Edwards M, Kanyuka K, Gatehouse A, Rudd J, Hammond-Kosack K, Pain N, Sadanandom A. Functional analysis of a Wheat Homeodomain protein, TaR1, reveals that host chromatin remodelling influences the dynamics of the switch to necrotrophic growth in the phytopathogenic fungus Zymoseptoria tritici. New Phytologist 2015, 206(2), 598-605. Guan W, Ferry N, Edwards MG, Bell HA, Othman H, Gatehouse JA, Gatehouse AMR. Proteomic analysis shows that stress response proteins are significantly up-regulated in resistant diploid wheat (Triticum monococcum) in response to attack by the grain aphid (Sitobion avenae). Molecular Breeding 2015, 35, 57. Xu LN, Wang ZY, Zhang J, Ferry N, Edwards MG, Gatehouse AMR, He KL. Characterization of four midgut aminopeptidase N isozymes from Ostrinia furnacalis strains with different susceptibilities to Bacillus thuringiensis. Journal of Invertebrate Pathology 2014, 115, 95-98. Jin TT, Chang X, Gatehouse AMR, Wang ZY, Edwards MG, He KL. Downregulation and Mutation of a Cadherin Gene Associated with Cry1Ac Resistance in the Asian Corn Borer, Ostrinia furnacalis (Guenée). Toxins 2014, 6(9), 2676-2693. Zhang TT, He MX, Gatehouse AMR, Wang ZY, Edwards MG, Li Q, He KL. Inheritance Patterns, Dominance and Cross-Resistance of Cry1Ab-and Cry1Ac-Selected Ostrinia furnacalis (Guenée). Toxins 2014, 6(9), 2694-2707. Nakasu EYT, Williamson SM, Edwards MG, Fitches EC, Gatehouse JA, Wright GA, Gatehouse AMR. Novel biopesticide based on a spider venom peptide shows no adverse effects on honeybees. Proceedings of the Royal Society B 2014, 281(1787), 20140619. Nakasu EYT, Edwards MG, Fitches E, Gatehouse JA, Gatehouse AMR. Transgenic plants expressing ω-ACTX-Hv1a and snowdrop lectin (GNA) fusion protein show enhanced resistance to aphids. Frontiers in Plant Science 2014, 5. Xu LN, Ferry N, Wang ZY, Zhang J, Edwards MG, Gatehouse AMR, He KL. A proteomic approach to study the mechanism of tolerance to Bt toxins in Ostrinia furnacalis larvae selected for resistance to Cry1Ab. Transgenic Research 2013, 22(6), 1155-1166. Tétard-Jones C, Edwards MG, Rempelos L, Gatehouse AMR, Eyre M, Wilcockson SJ, Leifert C. Effects of previous crop management, fertilization regime and watersupply on potato tuber proteome and yield. Agronomy 2013, 3(1), 59-85. Gatehouse AMR, Edwards MG, Ferry N, Owen MDK. Transgenic Crops, Environmental Impact. In: Meyers, R.A, ed. Encyclopedia of Sustainability Science and Technology. Dordrecht: Springer Science, 2012, pp.10713-10732. Gatehouse AMR, Ferry N, Edwards MG, Bell HA. Insect-resistant biotech crops and their impacts on beneficial arthropods. Philosophical Transactions of the Royal Society B: Biological Sciences 2011, 366(1569), 1438-1452. Edwards MG, Gatehouse JA, Gatehouse AMR. Molecular and biochemical characterisation of a dual proteolytic system in vine weevil larvae (Otiorhynchus sulcatus Coleoptera: Curculionidae). Insect Biochemistry and Molecular Biology 2010, 40(11), 785-791. Edwards MG, Poppy GM. Environmental Benefits of Genetically Modified Crops. In: Ferry, N., Gatehouse, A.M.R, ed. Environmental Impact of Genetically Modified Crops. Wallingford, UK: CAB International, 2009, pp.23-41. Edwards MG, Gatehouse AMR. Biotechnology in crop protection: Towards sustainable insect control. In: Vurro, M, Gressel, J, ed. Novel Biotechnologies for Biocontrol Agent Enhancement and Management. Netherlands: Springer, 2007, pp.1-23. Ferry N, Edwards MG, Gatehouse J, Capell T, Christou P, Gatehouse AMR. Transgenic plants for insect pest control: A forward looking scientific perspective. Transgenic Research 2006, 15(1), 13-19. Ferry N, Edwards MG, Mulligan EA, Emami K, Petrova AS, Frantescu M, Davison GM, Gatehouse AMR. Engineering resistance to insect pests. In: Christou, P; Klee, H, ed. Handbook of Plant Biotechnology. Hoboken, New Jersey: John Wiley & Sons, 2004, pp.373-394. Fitches E, Edwards MG, Mee C, Grishin E, Gatehouse AMR, Edwards JP, Gatehouse JA. Fusion proteins containing insect-specific toxins as pest control agents: Snowdrop lectin delivers fused insecticidal spider venom toxin to insect haemolymph following oral ingestion. Journal of Insect Physiology 2004, 50(1), 61-71. Ferry N, Edwards MG, Gatehouse JA, Gatehouse AMR. Plant-insect interactions: Molecular approaches to insect resistance. Current Opinion in Biotechnology 2004, 15(2), 155-161. Ferry N, Edwards MG, Gatehouse JA, Gatehouse AMR. Plant–insect interactions: molecular approaches to insect resistance. Current Opinion in Biotechnology 2004, 15(2), 155-161. Edwards MG, Ferry N, Mulligan EA, Emami K, Petrova AS, Frantescu M, Davison GM, Gatehouse AMR. The Role of Biotechnology in Crop Protection:Current Status and Future Perspectives. In: Atti dell'Accademia Nazionale Italiana di Entomologia Rendiconti. Florence: Accademia Nazionale Italiana di Entomologia, 2004, pp.133-152. Foissac X, Edwards MG, Du JP, Gatehouse AMR, Gatehouse JA. Putative protein digestion in a sap-sucking homopteran plant pest (rice brown plant hopper; Nilaparvata lugens: Delphacidae) - identification of trypsin-like and cathepsin B-like proteases. Insect Biochemistry and Molecular Biology 2002, 32(9), 967-978.