Boswell, Timothy - Newcastle University

研究领域

My research interests are centred on the neural and endocrine mechanisms that underpin feeding behaviour, metabolism, reproduction and stress responsiveness. I am particularly interested in how vertebrates, particularly birds, adjust their behaviour and physiology to environmental seasonality such as changes in photoperiod. I use a comparative, multi-disciplinary, approach that combines and integrates the genetic and molecular to the ecological and behavioural levels of biological organisation. In this way, I aim to gain insight into fundamental mechanisms regulating behaviour and physiology from the perspective of the whole animal. My research has involved the use of functional genomic technologies, including DNA microarrays, to identify genes in the brain involved in the control of seasonal physiology, and I have combined this with neurobiological approaches to characterise and monitor activity of neuroendocrine pathways. I am currently applying my knowledge of the neuroendocrine mechanisms underlying control of food intake and stress regulation to develop novel methods for assessing welfare in chickens and other livestock based on molecular markers.

近期论文

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Henderson LJ, Cockcroft RC, Kaiya H, Boswell T, Smulders TV. Peripherally injected ghrelin and leptin reduce food hoarding and mass gain in the coal tit (Periparus ater). In: SICB Annual Meeting 2016. 2016, Portland, Oregon: Oxford University Press. Dunn IC, Wilson PW, D'Eath RB, Boswell T. Hypothalamic Agouti-Related Peptide mRNA is Elevated During Natural and Stress-Induced Anorexia. Journal of Neuroendocrinology 2015, 27(9), 681-691. Boswell T, Dunn IC. Regulation of the avian central melanocortin system and the role of leptin. General and Comparative Endocrinology 2015, 221, 278-283. Cornelius JM, Boswell T, Jenni-Eiermann S, Breuner CW, Ramenofsky M. Contributions of endocrinology to the migration life history of birds. General and Comparative Endocrinology 2013, 190, 47-60. Dunn IC, Wilson PW, Smulders TV, Sandilands V, D'Eath RB, Boswell T. Hypothalamic Agouti-Related Protein Expression Is Affected by Both Acute and Chronic Experience of Food Restriction and Re-Feeding in Chickens. Journal of Neuroendocrinology 2013, 25(10), 920-928. Boswell T. Food intake: behavioral endocrinology. In: Breed, M.D., Moore, J, ed. Encyclopedia of Animal Behavior. Oxford, UK: Academic Press, 2010, pp.738-743. Boswell T. Molecular aspects of leptin in the chicken. In: Paolucci, M, ed. Leptin in non-mammalian vertebrates. Kerala, India: Transworld Research Network, 2010, pp.79-93. Graham G, Sharp PJ, Li Q, Wilson PW, Talbot RT, Downing A, Boswell T. HSP90B1, a thyroid hormone-responsive heat shock protein gene involved in photoperiodic signaling. Brain Research Bulletin 2009, 79(3-4), 201-207. Sharp PJ, Dunn IC, Waddington D, Boswell T. Chicken leptin. General and Comparative Endocrinology 2008, 158(1), 2-4. Holberton RL, Boswell T, Hunter MJ. Circulating prolactin and corticosterone concentrations during the development of migratory condition in the Dark-eyed Junco, Junco hyemalis. General and Comparative Endocrinology 2008, 155(3), 641-649. Tachibana T, Oikawa D, Adachi N, Boswell T, Furuse M. Central administration of alpha-melanocyte-stimulating hormone changes lipid metabolism in chicks. Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology 2007, 148(2), 408-412. Tachibana T, Oikawa D, Adachi N, Boswell T, Furuse M. Central administration of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide differentially regulates energy metabolism in chicks. Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology 2007, 147(1), 156-164. Tachibana T, Oikawa D, Adachi N, Boswell T, Furuse M. Intracerebroventricular injection of glucagon-like peptide-1 changes lipid metabolism in chicks. Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology 2007, 147(4), 1104-1108. Liu X, Dunn IC, Sharp PJ, Boswell T. Molecular cloning and tissue distribution of a short form chicken leptin receptor mRNA. Domestic Animal Endocrinology 2007, 32(3), 155-166. Tachibana T, Oikawa D, Takahashi H, Boswell T, Furuse M. The anorexic effect of alpha-melanocyte-stimulating hormone is mediated by corticotrophin-releasing factor in chicks. Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology 2007, 147(1), 173-178. Boswell T, Dunn IC, Wilson PW, Joseph N, Burt DW, Sharp PJ. Identification of a non-mammalian leptin-like gene: Characterization and expression in the tiger salamander (Ambystoma tigrinum). General and Comparative Endocrinology 2006, 146(2), 157-166. Tachibana T, Sato M, Oikawa D, Takahashi H, Boswell T, Furuse M. Intracerebroventricular injection of neuropeptide Y modifies carbohydrate and lipid metabolism in chicks. Regulatory Peptides 2006, 136(1-3), 1-8. Bromee T, Sjodin P, Fredriksson R, Boswell T, Larsson TA, Salaneck E, Zoorob R, Mohell N, Larhammar D. Neuropeptide Y-family receptors Y6 and Y7 in chicken: Cloning, pharmacological characterization, tissue distribution and conserved synteny with human chromosome region. FEBS Journal 2006, 273(9), 2048-2063. Tachibana T, Tsukada T, Fujimoto M, Takahashi H, Ohkubo T, Boswell T, Furuse M. Comparison of mammalian prolactin-releasing peptide and Carassius RFamide for feeding behavior and prolactin secretion in chicks. General and Comparative Endocrinology 2005, 144(3), 264-269. Ciccone NA, Dunn IC, Boswell T, Tsutsui K, Ubuka T, Ukena K, Sharp PJ. Gonadotrophin inhibitory hormone depresses gonadotrophin α and follicle-stimulating hormone β subunit expression in the pituitary of the domestic chicken. Journal of Neuroendocrinology 2005, 16(12), 999-1006. Boswell T, Takeuchi S. Recent developments in our understanding of the avian melanocortin system: Its involvement in the regulation of pigmentation and energy homeostasis. Peptides 2005, 26(10), 1733-1743. Boswell T. Regulation of energy balance in birds by the neuroendocrine hypothalamus. Journal of Poultry Science 2005, 42(3), 161-181. Tachibana T, Saito E-S, Takahashi H, Saito S, Tomonaga S, Boswell T, Furuse M. Anorexigenic effects of pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal peptide in the chick brain are mediated by corticotrophin-releasing factor. Regulatory Peptides 2004, 120(1-3), 99-105. Tachibana T, Saito S, Tomonaga S, Takagi T, Saito E-S, Nakanishi T, Koutoku T, Tsukada A, Ohkubo T, Boswell T, Furuse M. Effect of central administration of prolactin-releasing peptide on feeding in chicks. Physiology & Behavior 2004, 80(5), 713-719. Takeuchi S, Takahashi S, Okimoto R, Schi?th HB, Boswell T. Avian Melanocortin System: α-MSH May Act as an Autocrine/Paracrine Hormone: a mini review. Annals of the New York Academy of Sciences: The Melanocortin System 2003, 994(1), 366-372.