Beckmann, Roland - Ludwig-Maximilians-Universität München

个人简介

Studied biochemistry at FU Berlin 1995 PhD, FU Berlin 1995-2000 Postdoc at Rockefeller University, New York/USA 2001-2006 Group leader of VolkswagenStiftung at Charité, HU, Berlin Since 2006 Professor of Biochemistry (W3), LMU

研究领域

Structure/function of protein targeting and translocation complexes. High resolution of cryo-electron microscopy (cryo-EM) and single particle analysis of macromolecular complexes. Analysis of co-translational interactions of the nascent polypeptide c

近期论文

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Leidig, C., Thoms, M., Holdermann, I., Bradatsch, B., Berninghausen, O., Bange, G., Sinning, I., Hurt, E. and Beckmann, R. (2014) Construction of the central protuberance requires rotation of 5S RNP during 60S ribosome biogenesis. Nature Comm., in press Gogala, M., Becker, T., Beatrix, B., Armache, J.-P., Barrio-Garcia, C., Berninghausen, O. and Beckmann, R. (2014). Structures of the Sec61-complex engaged in nascent peptide translocation or membrane insertion. Nature, doi:10.1038/nature12950 Pfeffer, S., Dudek, J., Gogala, M., Schorr, S., Linxweiler, J., Lang, S., Becker, T., Beckmann, R., Zimmermann, R., Förster, F. (2014). Structure of the mammalian oligosaccharyl-transferase complex in the native ER protein translocon. Nature Comm., Jan 10;5:3072. doi: 10.1038/ncomms4072 Seitl, I., Wickles, S., Beckmann, R., Kuhn, A. and Kiefer, D. (2014). The C-terminal regions of YidC from Rhodopirellula baltica and Oceanicaulis alexandrii bind to ribosomes and partially substitute for SRP receptor function in Escherichia coli. Molecular Microbiology, 91, 408-21. Tosi, A., Haas, C., Herzog, F., Gilmozzi, A., Berninghausen, O., Ungewickell, C., Gerhold, C.B., Lakomek, K., Aebersold, R., Beckmann, R., Hopfner K.P. (2013). Structure and subunit topology of the INO80 chromatin remodeler and its nucleosome complex. Cell 154, 1207-1219. Anger A.M., Armache J.P., Berninghausen O., Habeck M., Subklewe M., Wilson D.N., and Beckmann R. (2013). Structures of the human and Drosophila 80S ribosome Nature 497, 80-85 Leidig, C., Bange, G., Kopp,J., Amlacher, S., Aravind, A., Wickles,S., Witte,G., Hurt,E., Beckmann, R., and Sinning I. (2013). Structural characterization of a eukaryotic chaperone, the ribosome-associated complex (RAC). Nat Struct Mol Biol 20, 23-28 Norousi, R., Wickles, S., Leidig, C., Becker, T., Schmid, V.J., Beckmann, R. Tresch, A. (2013). Automatic post-picking using MAPPOS improves particle image detection from cryo-EM micrographs. J Struct Biol. 182(2):59-66 Armache, J.P., Anger A.M., Márquez V., Franckenberg S., Fröhlich T., Villa E., Berninghausen O., Thomm M., Arnold G.J., Beckmann R., and Wilson D.N. (2013). Promiscuous behaviour of archaeal ribosomal proteins: implications for eukaryotic ribosome evolution Nucleic Acids Research 41, 1284-1293 Bradatsch, B., Leidig, C., Granneman, S., Gnadig, M., Tollervey, D., Bottcher, B., Beckmann, R., and Hurt, E. (2012). Structure of the pre-60S ribosomal subunit with nuclear export factor Arx1 bound at the exit tunnel. Nat Struct Mol Biol 19, 1234-1241 Franckenberg, S., Becker, T., and Beckmann, R. (2012). Structural view on recycling of archaeal and eukaryotic ribosomes after canonical termination and ribosome rescue. Current opinion in structural biology 22, 786-796 Dönhöfer, A., Franckenberg, S., Wickles, S., Berninghausen, O., Beckmann, R., and Wilson, D.N. (2012). Structural basis for TetM-mediated tetracycline resistance. Proc Natl Acad Sci U S A 109, 16900-16905. Gumbart, J., Schreiner, E., Wilson, D.N., Beckmann, R., and Schulten, K. (2012). Mechanisms of SecM-mediated stalling in the ribosome. Biophysical journal 103, 331-341. Grela, P., Gajda, M.J., Armache, J.P., Beckmann, R., Krokowski, D., Svergun, D.I., Grankowski, N., and Tchorzewski, M. (2012). Solution structure of the natively assembled yeast ribosomal stalk determined by small-angle X-ray scattering. The Biochemical journal 444, 205-209. Becker, T., Franckenberg, S., Wickles, S., Shoemaker, C.J., Anger, A.M., Armache, J.P., Sieber, H., Ungewickell, C., Berninghausen, O., Daberkow, I., Karcher, A., Thomm, M., Hopfner, KP., Green, R., Beckmann, R. (2012). Structural basis of highly conserved ribosome recycling in eukaryotes and archaea. Nature 482, 501-506. Jarasch, A., Dziuk, P., Becker, T., Armache, J.P., Hauser,A., Wilson, D.N., and Beckmann, R. (2012). The DARC site: a database of aligned ribosomal complexes Nucleic Acids Research, 40, 495-500. Database: The DARC site Wollmann, P., Cui, S., Viswanathan, R., Berninghausen, O., Wells, M.N., Moldt, M., Witte, G., Butryn, A., Wendler, P., Beckmann, R., Auble, D.T., and Hopfner, K.P. (2011). Structure and Mechanism of the Swi2/Snf2 Remodeller Mot1 in Complex with Its Substrate Tbp. Nature 475, 403-407. Wilson, D.N., Bhushan, S., Becker, T., and Beckmann, R. (2011). Nascent polypeptide chains within the ribosomal tunnel analyzed by Cryo-EM. In: Eds. Rodnina, M, Wintermeyer, W, and Green, R Ribosomes: Structure, Function and Dynamics.(Springer-Verlag, Wien). Frauenfeld, J., Gumbart, J., Sluis, E.O., Funes, S., Gartmann, M., Beatrix, B., Mielke, T., Berninghausen, O., Becker, T., Schulten, K., and Beckmann, R. (2011). Cryo-EM Structure of the Ribosome-Sec YE Complex in the Membrane Environment. Nat Struct Mol Biol 18, 614-621.