Shah, Ajit - Middlesex University - Department of Natural Sciences

研究领域

Development and application of liquid chromatography and mass spectrometry for analysis of biomolecules Metabolomics - to identify small molecules as predictive and diagnostic biomarkers of disease Proteomics - to obtain a more global and integrated view of biology by studying all the proteins of a cell rather than each one individually Development of analytical instruments for analysis of biomolecules

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Shah, A. J.; Adlard, M. W. Trace level measurement of b-lactam antibiotics and biosynthetic intermediates following precolumn derivatisation with 9-fluoroenylmethylcholorformate. J. Chromatog. (1988) 325-336. Shah, A. J.; Adlard, M. W.; Holt, G. Quantitation of natural penicillins in fermentation media by high performance liquid chromatography using precolumn derivatisation with 1-hydroxybenzo-triazole. Analyst (1988) 1197-200. Shah, A. J.; Adlard, M. W.; Stride, J. D. A sensitive assay for clavulanic acid and sulbactam in biological fluids by high performance liquid chromatography and precolumn derivatisation. J. Pharm. Biomed. Anal. (1990) 437-443. Shah, A. J.; Tilburn, J.; Adlard, M. W.; Arst, H. N., Jr. pH Regulation of penicillin production in Aspergillus nidulans.FEMS Microbiol. Letts. (1991) 209-212. Shah, A. J.; Younie, D. A.; Adlard, M. W.; Evans, C. S. High-performance liquid chromatography of non-protein amino acids produced in Acacia seeds. Phytochem. Anal. (1992) 20-25. Evans, C. S.; Shah, A. J.; Adlard, M.W.; Arce, M. L. R. Non-protein amino acids in seeds of neotropical species of Acacia. Phytochemistry (1992) 123-126. Shah A.J; Orford C D.; Adlard M. W. Derivatisation methods for trace-level quantification of b-lactam antibiotics. LC-GC (1993). Shah, A. J.; Younie, D. A.; Adlard, M. W.; Evans, C. S. Evolutionary trends within genus Acacia based on the accumulation of non-protein amino acids in seeds. Advance in legume Systematics 5 (1994). Shah, A.; de Biasi, V.; Camilleri, P. Development of a spectrophotometric method for the measurement of thiols at trace levels. Anal. Proceedings (1995) 149-153. Shah, A; Rahman S.S; Biasi V. de; Camilleri P; Development of a colorimetric method for the detection of amines bound to solid support. (1995) 149-153. Hagan, J. J.; Leslie, R. A.; Patel, S.; Evans, M. L.; Wattam, T. A.; Holmes, S.; Benham, C. D.; Taylor, S. G.; Routledge, C.; Hemmati, P.; Munton, R. P.; Ashmeade, T. E.; Shah, A. J.; Hatcher, J. P.; Hatcher, P. D.; Jones, D. N. C.; Smith, M. I.; Piper, D. C.; Hunter, A. J.; Porter, R. A.; Upton, N. CNS Localisation and Effects of Orexin-A.Proceedings of the National Academy of Sciences of the United States of America (1999) 10911-10916. Shah, A. J.; de Biasi, V.; Taylor, S. G.; Roberts, C.; Hemmati, P.; Munton, R.; West, A.; Routledge, C.; Camilleri, P. Development of a protocol for the automated analysis of amino acids in brain tissue samples and microdialysates. J. Chrom. B: Biomedical Sciences and Applications (1999) 133-140 Hadley M; Gilges M; Senior J; Shah A; Camilleri; Capillary Electrophoresis in the pharmaceutical industry:applications in discovery and chemical development.J. Chrom. B: Biomedical Sciences and Applications (1999) 177-188. Hemmati, P.; Shilliam, C. S.; Hughes, Z. A.; Shah, A. J.; Roberts, J. C.; Atkins, A. R.; Hunter, A. J.; Heidbreder, C. A. In vivo characterization of basal chemoneuroanatomical markers for amino acids in the shell and core subterritories of the nucleus accumbens. Neurochemistry International (2001) 199-208. Heidbreder, C. A.; Lacroix, L.; Atkins, A. R.; Organ, A. J.; Murray, S.; West, A.; Shah, A. J. Development and application of a sensitive high performance ion-exchange chromatography method for the simultaneous measurement of dopamine, 5-hydroxytryptamine and norepinephrine in microdialysates from the rat brain. Journal of Neuroscience Methods (2001) 135-144. Senior J; Shah A; Monteux C; Biasi V De; The evaluation of interdigitated array electrodes for the measurement of catecholamines and indoleamines. J. Pharm. Biomed. Anal. (2001) 843-848. Tolson, D.; Organ, A.; Shah, A. Development of a high-pressure gradient pumping system for parallel liquid chromatography/mass spectrometry for the analysis of combinatorial libraries. Rapid Comm. Mass Spectro. (2001) 1244-1249. Heidbreder, C. A.; Foxton, R.; Cilia, J.; Hughes, Z. A.; Shah, A. J.; Atkins, A.; Hunter, A. J.; Hagan, J. J.; Jones, Declan N. C. Increased responsiveness of dopamine to atypical, but not typical antipsychotics in the medial prefrontal cortex of rats reared in isolation. Psychopharmacology (2001) 338-351 Hows, M, E. P.; Organ, A. J.; Murray, S.; Dawson, L. A.; Foxton, R.; Heidbreder, C.; Hughes, Z. A.; Lacroix, L.; Shah, A. J. High-performance liquid chromatography/tandem mass spectrometry assay for the rapid high sensitivity measurement of basal acetylcholine from microdialysates. J. Neuroscience Methods (2002) 33-39. Shah, A. J.; Crespi, F.; Heidbreder, C. Amino acid neurotransmitters: separation approaches and diagnostic value. J. Chromatog. B: Analytical Technologies in the Biomedical and Life Sciences (2002) 151-163. Lacroix, L. P.; Hows, M. E. P.; Shah, A. J.; Hagan, J. J.; Heidbreder, C. A. Selective Antagonism at Dopamine D3 Receptors Enhances Monoaminergic and Cholinergic Neurotransmission in the Rat Anterior Cingulate Cortex. Neuropsychopharmacology (2003) 839-849. Dawson, L. A.; Organ, A. J.; Winter, P.; Lacroix, L. P.; Shilliam, C. S.; Heidbreder, C.; Shah, A. J. Rapid high-throughput assay for the measurement of amino acids from microdialysates and brain tissue using monolithic C18-bonded reversed-phase columns. J. Chromatog. B: Analytical Technologies in the Biomedical and Life Sciences (2004) 235-241. Hows, M. E. P.; Lacroix, L.; Heidbreder, C.; Organ, A.J.; Shah, A. J. High-performance liquid chromatography/tandem mass spectrometric assay for the simultaneous measurement of dopamine, norepinephrine, 5-hydroxytryptamine and cocaine in biological samples. J. Neuroscience Methods (2004) 123-132. Hows, M. E. P.; Ashmeade, T. E.; Billinton, A.; Perren, M. J.; Austin, A. A.; Virley, D. J.; Organ, A. J.; Shah, A. J. High-performance liquid chromatography/tandem mass spectrometry assay for the determination of 1-methyl-4-phenyl pyridinium (MPP+) in brain tissue homogenates. J. of Neuroscience Methods (2004) 221-226. Shah, A. J.; De la Flor, R.; Atkins, A.; Dawson, L. A. Development and application of a liquid chromatography/tandem mass spectrometric assay for measurement of N-acetylaspartate, N- acetylaspartylglutamate and glutamate in brain slice superfusates and tissue extracts. J. Chromatogr. B: Analytical Technologies in the Biomedical and Life Sciences (2008) 153-158.