个人简介

B.A. Carleton College, 1992 Ph.D. Yale University, 1999 NIH Postdoctoral Fellow, Harvard University, 1999-2001

研究领域

Protein post-translational modification/histone deacetylase proteins/chemical genetics/medicinal chemistry

Research in the Pflum group integrates organic chemistry, biochemistry, and cell biology to understand the molecular basis of disease. For many years, we have been particularly interested in two proteins associated with cancer formation- kinase and histone deacetylase enzymes. Our goal is to use a chemical approach to characterize the role of these proteins in cancers, which will lead to identification of novel drugs targeting these proteins and biomarkers to diagnose illness.

近期论文

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Kinase-Catalyzed Biotinylation of Peptides, Proteins, and Lysates, Chamara Senevirathne, Keith D. Green, and Mary Kay H. Pflum, Curr Protocols in Chem Biol, 2012, 83-100 The Structural Requirements of Histone Deacetylase Inhibitors: Suberoylanilide Hydroxamic Acid Analogues Modified at the C3 Position Display Isoform Selectivity, Sun Ea Choi, Sujith V. W. Weerasinghe and Mary Kay H. Pflum, Bioorg Med Chem Lett, 2011, 21, 6139-6142 A Histone Deacetylase-Dependent Screen in Yeast, Sujith V. W. Weerasinghe, Magdalene Wambua and Mary Kay H. Pflum, Bioorganic and Medicinal chemistry, 2010, 18, 7586-7592 Phosphorylation-Dependent Kinase-Substrate Cross-Linking, Sujit Suwal, Mary Kay H. Pflum, Angewandte Chemie International Edition, 2010, 49 (9), 1627-1630. Exploring Kinase Cosubstrate Promiscuity: Monitoring Kinase Activity through Dansylation, Keith D. Green and Mary Kay H. Pflum, ChemBioChem, 2009, 10 (2), 234-237. Residues in the 11 ? Channel of Histone Deacetylase 1 Promote Catalytic Activity: Implications for Designing Isoform-Selective Histone Deacetylase Inhibitors, Sujith V. W. Weerasinghe, Guillermina Estiu, Olaf Wiest, and Mary Kay H. Pflum, J. Med. Chem., 2008, 51 (18), 5542-5551. Structural Requirements of HDAC Inhibitors: SAHA Analogs Functionalized Adjacent to the Hydroxamic Acid, Anton V. Bieliauskas, Sujith V. W. Weerasinghe and Mary Kay H. Pflum, Bioorg. Med. Chem. Lett., 2007, 17 (8), 2216-2219. Kinase-Catalyzed Biotinylation for Phophoprotein Detection, Keith D. Green and Mary Kay H. Pflum, J. Am. Chem. Soc., 2007, 129 (1), 10-11.