个人简介

B.S., University of Wisconsin-Madison, 1998 Ph.D., University of California-Irvine, 2003 NIH Postdoctoral Fellow, Massachusetts Institute of Technology, 2003-6

研究领域

Organic synthesis/inorganic synthesis/metal-based drug design/catalysis/iron chemistry/ligand design and coordination chemistry.

Research in the Kodanko laboratory applies synthetic chemistry to problems in medicine and catalysis. In our studies we call upon multiple disciplines, including organic, organometallic, inorganic, and medicinal chemistry. One major area of interest in our lab is designing catalytic drugs. Most drugs today are stoichiometric, where a drug molecule can interact with its biological target only one molecule at a time. To create catalytic drugs, our strategy is to take advantage of the special reactivity one can achieve with metal complexes. By harnessing this reactivity, we plan to develop new molecules that can inactivate biological targets catalytically and with high selectivity. This technology would make agents that target biomolecules effective at lower concentrations, which in turn has potential to lower dosage amounts and eliminate side effects when compared with conventional drugs. In particular, we are interested in targeting proteins with iron-based oxidants. We have focused on iron because it is the most abundant transition metal in the human body and because recent advancements in the field of iron chemistry have demonstrated that iron complexes can be selective yet powerful oxidants. Therefore we have initiated a research program with the goal of understanding how iron-based oxidants can functionalize the amino acid residues of proteins and how these modifications can disrupt protein function. We consider the metalloantibiotic bleomycin (BLM) a model for our work in this area. Used for decades in cancer chemotherapy, BLM can catalytically degrade DNA in the presence of Fe(II) and O2.

近期论文

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Ekkati, A. R.; Kodanko, J. J. " Targeting Peptides with an Iron-Based Oxidant: Cleavage of the Amino Acid Backbone and Oxidation of Side Chains" J. Am. Chem. Soc. 2007, 129, 12390. Kodanko, J. J.; Xu, D.; Lippard, S. J. "Iron Substitution of Sodium in a Carboxylate-Bridged, Heterodinuclear Sodium-Iron Complex" J. Am. Chem. Soc. 2005, 127, 16004. Kodanko, J. J.; Morys, A. J.; Lippard, S. J. "Synthesis of Diethynyltriptycene-Linked Dipyridyl Ligands" Org. Lett, 2005, 7, 4585. Huang, A.; Kodanko, J. J.; Overman, L. E. "Asymmetric synthesis of pyrrolidinoindolines. Application for the practical total synthesis of (-)-phenserine" J. Am. Chem. Soc. 2004, 126,14043. Dounay, A.; Hatanaka, K.; Kodanko, J. J.; Oestreich, M.; Overman, L. E.; Pfeifer, L. Weiss, M. M. "Enantioselective Synthesis of 3-Alkyl-3-Aryl Oxindoles by Catalytic Asymmetric Heck Reactions" J. Am. Chem. Soc. 2003, 125, 6261. Kodanko, J. J., Overman, L. E. "Enantioselective Total Syntheses of the Cyclotryptamine Alkaloids Hodgkinsine and Hodgkinsine B" Angew. Chem. Int. Ed. 2003, 42, 2528.