Stupp, Samuel I. - Northwestern University

个人简介

Professional Appointments 2021-present Severo Ochoa Distinguished Professor, Institute for Bioengineering of Catalonia, Spain 2020-present Visiting Professor, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 2015-2020 Visiting Professor, School of Materials Science & Engineering, Nanyang Technological University, Singapore 2014-present Director, Center for Bio-Inspired Energy Science, Northwestern University 2014-2024 Director, Simpson Querrey Institute, Northwestern University 2013-present Board of Trustees Professor of Biomedical Engineering, Northwestern University 2012-present Director, Louis A. Simpson and Kimberly K. Querrey Center for Regenerative Nanomedicine, Northwestern University 2000-2014 Director, Institute for BioNanotechnology in Medicine, Northwestern University 1999-present Board of Trustees Professor of Materials Science, Chemistry, and Medicine, Northwestern University 1992-1999 Professor of Chemistry, University of Illinois at Urbana-Champaign 1989-1999 Professor of Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign 1989-1999 Professor of Materials Science and Engineering and Bioengineering, University of Illinois at Urbana-Champaign 1996-1998 Swanlund Professor of Materials Science and Engineering, Chemistry, and Bioengineering, University of Illinois at Urbana-Champaign 1997 CNRS Visiting Professor, Institut Charles Sadron, Strasbourg, France 1991-1994 Chairman of Polymer Division, Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign 1985-1989 Associate Professor of Materials Science and Engineering and Bioengineering, University of Illinois at Urbana-Champaign 1980-1985 Assistant Professor of Materials Science and Engineering and Bioengineering, University of Illinois at Urbana-Champaign 1977-1980 Assistant Professor, Department of Biological Materials, Northwestern University

研究领域

Research in the Stupp group integrates chemistry with materials science, biology, and medicine. The overarching interest of the group is the development of self-assembling organic materials, focusing on functions relevant to energy and medicine. In the area of energy science, the laboratory’s interests include materials for solar photovoltaics, catalytic materials that can synthesize solar fuels, supramolecular ferroelectrics for non-volatile memories, and artificial muscle materials for inter-conversion of chemical and mechanical energy. In the area of medicine, the Stupp laboratory focuses on biomaterials for regenerative medicine of the brain, spinal cord, bone, cartilage and muscle, and also on targeted systemic drug delivery using nanostructures for cancer and cardiovascular applications. The organic structures of interest in both areas include visible-light-absorbing chromophores, organometallic catalysts, electron donors and acceptors, DNA, peptides, glycopeptides, and polymers, among others. The group is organized into three subgroups that meet weekly to discuss progress: Energy Materials, Biomaterials, and Supramolecular Self-Assembly. Research activities include molecular synthesis and characterization of structure with a broad suite of microscopies and synchrotron X-ray scattering, measurement of materials properties, computer simulations, construction of solar cells and other electronic devices, molecular and cell biology, and in vivo studies of the efficacy of materials and nanostructures in biomedical applications.

近期论文

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Stupp, S.I.; Palmer, L.C. “New frontiers in supramolecular design of materials” MRS Bulletin 2024, https://doi.org/10.1557/s43577-024-00669-x Lee, S.; Carrow, J.K.; Fraser, L.A.; Yan, J.; Jeyamogan, S.; Sambandam, Y.; Clemons, T.D.; Kolberg-Edelbrock, A.; He, J.; Mathew, J.; Zhang, Z.; Leventhal, J.P.; Gallon, L.; Palmer, L.C.; Stupp, S.I. “Single Cell-Coating with Biomimetic Extracellular Nanofiber Matrices” Acta Biomaterialia 2024, 177, 50-61. Xing,H.; Wigham, C. ; Lee, S.R.; Pereira, A.J.; de Campos, L.J.; Picco, A.S.; Huck-Iriart, C.; Escudero,C.; Perez-Chirinos, L.; Gajaweera, S.; Comer, J.; Sasselli, I.R.; Stupp, S.I.; Zha, H.R.; Conda-Sheridan, M. “Enhanced Hydrogen Bonding by Urea Functionalization Tunes the Stability and Biological Properties of Peptide Amphiphiles” Biomacrocolecules 2024, 25 (5), 2823-2837 Clemons, T.D.; Egner, S.A; Grzybek, J.; Roan, J.J.; Sai, H.; Yang, Y.; Syrgiannis, Z.; Hun, H.; Palmer, L.C.; Gianneschi, N.C.; Stupp, S.I. “Hybrid Bonding Bottlebrush Polymers Grafted from a Supramolecular Polymer Backbone” Journal of the American Chemical Society 2024, 146, 16085-16096. Sangji, M.H.; Lee, S.R.; Sai, H.; Weigand, S.J.; Palmer, L.C.; Stupp, S.I. “Self-Sorting vs. Co-Assembly in Peptide Amphiphile Supramolecular Nanostructures” ACS Nano 2024, 18(24) 15878-15887. Emmanuele, R.; Sai, H.; Chen, J-S.; Morrow, D.J.; Dordevic, L.; Gosztola, D.J.; Hla, S.W.; Stupp, S.I.; Ma, X. “Lattice Symmetry-Guided Charge Transport in Two-Dimensional Supramolecular Polymers Promotes Triplet Formation” Advanced Science 2024, 2402932 https://doi.org/10.1002/advs.202402932 Kupferberg, J.E.; Syrgiannis, Z.; Dordevic, L.; Bruckner, E.P.; Jaynes, T.J.; Ha, H.; Qi, E.; Wek, K.S.; Dannenhoffer, A.J.; Sather, N.A.; Fry, H.C.; Palmer, L.C.; Stupp, S.I. “Biopolymer-Supramolecular Polymer Hybrids for Photocatalytic Hydrogen Production” Soft Matter 2024, DOI: 10.1039/d4sm00373j Yuan, S.C.; Alvarez, Z.; Lee, S.R.; Pavlovic, R.; Yuan, C.; Singer, E.; Weigand, S.J.; Palmer, L.C.; Stupp, S.I. “Supramolecular Motion Enables Chondrogenic Bioactivity of a Cyclic Peptide Mimetic of Transforming Growth Factor-β1” Journal of the American Chemical Society 2024, https://doi.org/10.1021/jacs.4c05170 Lewis, J.A.; Nemke, B.; Lu, Y.; Sather, N.A.; McClendon, M.T.; Mullen, M.; Yuan, S.C.; Ravuri, S.K.; Bleedorn, J.A.; Huard, J.; Markel, M.D., Stupp, S.I. “A Bioactive Supramolecular and Covalent Polymer Scaffold for Cartilage Repair in a Sheep Model” PNAS 2024 121(33) e2405454121 Cezan, S.D.; Li, C.; Kupferberg, J.; Dordevic, L.; Aggarwal, A.; Palmer, L.C.; Olvera de la Cruz, M.; Stupp, S.I. “Autonomous Phototaxis of Hydrogel Swimmers” Advanced Functional Materials 2024 https://doi.org/10.1002/adfm.202400386. Dannenhoffer, A.; Sai, H.; Bruckner E.P.; Ðorđević, L.; Narayanan, A.; Yang, Y.; Ma, X.; Palmer L.C.; Stupp S.I. “Metallurgical Alloy Approach to Two-Dimensional Supramolecular Materials” Chem 2023, 9(1), 170-180. Alvarez, Z; Ortega, J. A.; Sato, K.; Sasselli, I. R; Edelbrock, A. N.; Quinlan, K. A.; Mussumeci, C.; Stupp, S. I.; Kiskinis, E. “Artificial Extracellular Matrix Scaffolds of Mobile Molecules Enhance Maturation of Human Stem Cell-Derived Neurons” Cell Stem Cell 2023, https://doi.org/10.1016/j.stem.2022.12.010 Yamaura, K.; Sather N.A.; Metlushko, A.; Nishimura, H.; Pavlović, R.; Hambright, S.; Kumar Ravuri, S.; Philippon, M.J.; Stupp, S.I.; Bahney, C.; Huard, J. “Sustained-release losartan from peptide nanofibers promotes chondrogenesis” Frontiers in Bioengineering and Biotechnology 2023, 11, 2296-4185. Kolberg-Edelbrock, J; Cotey, T.J.; Ma, S.Y.; Kapsalis, L.M.; Bondoc, D.M.; Kolberg-Edelbrock, A.N.; Stupp, S.I. “Biomimetic Extracellular Scaffolds by Microfluidic Superstructuring of Nanofibers” ACS Biomaterials Science and Engineering 2023, DOI: 10.1021/acsbiomaterials.2c01098. Đorđević, L.; Sai, H, Sather, N.A.; Yang, Y.; Palmer, L.C.; Stupp, S.I. “Heterocyclic Chromophore Amphiphiles and their Supramolecular Polymerization” Angewandte Chemie Int. Ed. e202214997, 2023, https://doi.org/10.1002/anie.202214997 Pavlović, R. Z.; Egner, S.A.; Palmer, L.C.; Stupp. S.I. “Supramolecular Polymers: Dynamic Assemblies of “Dancing” Monomers” Journal of Polymer Science 2023, https://doi.org/10.1002/pol.20230115 Li, C.; Kazem-Rostami, M.; Seale, J.; Zhou, S.; Stupp, S.I. “”Macroscopic Actuation of Bisazo Hydrogels Driven by Molecular Photoisomerization” Chemistry of Materials 2023, https://doi.org/10.1021/acs.chemmater.3c00062 Searl, T.; Martin,S.; Harrington, D.; Ohlander, S.; Stupp, S.I.; Mcvary, K.; Podlasek, C. “RNAseq and Pathway Analysis of Rat Penis with Cavernous Nerve Injury and Sonic Hedgehog Treatment by Peptide Amphiphile” The Journal of Urology 2023, 209(4), e362. Martin,S.; Deng, J.; Searl, T.; Ohlander, S.; Harrington, D.; Stupp,S.I.; Mcvary,K.; Podlasek, C. “Analysis of BMP4 and GREMLIN as targets of SHH signaling and regulators of the collagen axis in the penis” The Journal of Sexual Medicine, 2023, 20(1). Searl, T.; Martin,S.; Harrington, D.; Ohlander, S.; Stupp, S.I.; Mcvary, K.; Podlasek, C. “RNAseq and Pathway Analysis of Rat Penis with Cavernous Nerve Injury and Sonic Hedgehog Treatment by Peptide Amphiphile” The Journal of Sexual Medicine 2023, 20(1). Duan, J; Shabbir, H; Chen, Z; Bi, W; Liu, Q; Sui, J ; Đorđević, L; Stupp, S.I.; Chapman, K; Martinson, A; Li, A; Goswami, S; Getman, R ; Hupp, J. “Synthetic access to a framework-stabilized and fully sulfided analogue of an Anderson polyoxometalate that is catalytically competent for reduction reactions” Journal of the American Chemical Society 2023, 145(13), 7268–7277. Li, C.; Xiong, Q.; Clemmons, T.; Sai, H.; Yang, Y.; Sangji, M.H.; Iscen, A.; Palmer, L.C.; Schatz, G.C.; Stupp, S.I. “Role of Supramolecular Polymers in Photo-actuation of Spiropyran Hydrogels” Chemical Science. 2023, DOI: 10.1039/D3SC00401E Qiu, R; Chen, F; Alvarez, Z; Clemons, T; Biswas, S; Karver, M.; Takata , N; Sai, H; Peng, H; Weigand, S; Palmer, L.C.; Stupp, S.I. “Supramolecular Nanofibers Block SARS-CoV-2 Entry into Human Host Cells” ACS Applied Materials & Interfaces 2023, 15 (22), 26340-26348PMCID #PMC10237298 Yang, Y.; Li, C.; Palmer, L.C.; Stupp, S.I. “Autonomous Hydrogel Locomotion Regulated by Light and Electric Fields” Science Advances 2023, 9 (31), eadi4566 Smith, C. S.; Álvarez, Z.; Qui, R.; Sasseli, I.; Clemons, T.; Ortega, J.A.; Viliela-Picos, M.; Wellman, H.; Kiskinis, E.; Stupp, S.I. “Enhanced Neuron Growth and Electrical Activity by a Supramolecular Netrin-1 Mimetic Nanofiber” ACS Nano 2023, https://doi.org/10.1021/acsnano.3c04572 Pavlović, R.Z.; Finnegan, T. J.; Metlushko, A.; Hansen, A. L.; Waudby, C. A.; Wang, X.; Hoefer, N.; McComb, D. W.; Pavic, A.; Plackic, N.; Novakovic, J.; Bradic, J.; Jeremic, N.; Jakovljevic, V.; Smit, B.; Matic, S.; Alvarez-Saavedra, M. A., Capo, I.; Moore, C. E.; Stupp, S. I. “Dynamic and Assembly Characteristics of Deep‐Cavity Basket Acting as a Host for Inclusion Complexation of Mitoxantrone in Biotic and Abiotic Systems” Chemistry : a European Journal 2023, 29(68), e202303374 Ortega, J. A; Sasselli, I. R.; Boccitto, M.; Fleming, A. C.; Fortuna, T.; Li, Y.; Sato, K.; Clemons, T. D.; McKenna, E.; Nguyen, T. P.; Anderson, E.; Ichida, J.; Pandey, U.; Wolin, S.; Stupp, S. I.; Kiskinis, E. “CLIP-Seq Analysis Enables the Design of Ribosomal RNA Bait Oligonucleotides That Protect Against C9ORF72 ALS/FTD-Associated Poly-GR Pathophysiology” Science Advances 2023, 9(43). Stone, E.B.S; Đorđević, L.; Stupp, S.I.; Weiss, E.A.; Arcudi, F.; Hupp, J.T. “Selective Photocatalytic Reduction of Acetylene to Ethylene Powered by a Cobalt-Porphyrin Metal–Organic Framework” ACS Energy Letters 2023, 8(11), 4684–4693. Zhou,Y.; Fyrner, T; Chen. C; Sather, N.; Hsu, E.; Stupp, S.I.; Snead, M.L. “Optimization of peptide amphiphile-lipid raft interaction by changing PA lipophilicity” Acta Biomaterialia 2023, 164, 377–386 PMCID:PMC10225347 McClendon, M.; Ji, W.; Greene, A.C.; Sai, H.; Sangji, M. H.; Chen, C.H.; Lee, S.S.; Katchko, K.; Jeong, S.S.; Kannan, A.; Weiner, J.; Cook, R.; Driscoll, A.; Lubbe, R.; Chang. K.; Haleem, M.; Chen, F.; Qiu, R.; Chun, D.; Stock, S.R.; Hsu, W.K.; Hsu, E.L.; Stupp, S.I. “A Supramolecular Polymer-Collagen Microparticle Slurry for Bone Regeneration with Minimal Growth Factor” Biomaterials 2023, 302, 122357. Barlek, M.H.; Gillis, D.C.; Egner, S.A.; Maragos, S.L.; Karver, M.R.; Stupp, S.I.; Tsihlis, N.D.; Kibbe, M.R.; “Systemic peptide amphiphile nanofiber delivery following subcutaneous injection” Biomaterials 2023, 303, 122401. Sasselli, I. R.; Syrgiannis, Z.; Sather, N.; Palmer, L. C; Stupp. S. I.; “Modelling Interactions Within and Between Peptide Amphiphile Supramolecular Filaments” Physical Chemistry B 2022,126(3), 650-659. Dumele, O.; Dordevic, L.; Sai, H.; Cotey, T. J.; Sangji, M. H.; Sato, K.; Dannenhoffer, A. J.; Stupp, S. I. “Photocatalytic Aqueous CO2 Reduction to CO and CH4 Sensitized by Ullazine Supramolecular Polymers” Journal of the American Chemical Society 2022, 144 (7), 3127-3136. Aggarwal, A.; Li, C.; Stupp, S. I.; Olvera de la Cruz, M. “Controlling the Shape Morphology of Origami-Inspired Photoresponsive Hydrogels” Soft Matter 2022, 18, 2193-2201. PMCID: PMC8989053 NIHMSID: NIHMS1785846 Nap, R. J.; Qiao, B.; Palmer, L. C.; Stupp, S. I.; Olvera de la Cruz, M.; Szleifer, I. “Acid-Base Equilibrium and Dielectric Environment Regulate Charge in Supramolecular Nanofibers” Frontiers in Chemistry 2022, 10:852164. PMCID: PMC8965714 Bruckner, E.P.; Stupp, S. I. “Designing Supramolecular Polymers with Nucleation and Growth Processes” Polymer International 2022, 71, 590-595. Qiu, R.; Sasselli, I. R.; Álvarez, Z.; Sai, H.; Ji, W.; Palmer, L. C.; Stupp, S. I. “Supramolecular Copolymers of Peptides and Lipidated Peptides and their Therapeutic Potential” Journal of the American Chemical Society 2022, 144 (12) 5532-5574. Arcudi, F.; Dordevic, L.; Schweitzer, N.; Stupp, S. I.; Weiss, E. A. “Selective Visible-Light Photocatalysis of Acetylene to Ethylene Using a Cobalt Molecular Catalyst and Water as a Proton Source” Nature Chemistry 2022, https://doi.org/10.1038/s41557-022-00966-5. Bruckner, E. P.; Curk, T.; Dordevic, L.; Wang, Z.; Yang, Y.; Qiu, R.; Dannenhoffer, A. J.; Sai, H.; Kupferberg, J.; Palmer, L. C.; Luijten, E.; Stupp, S. I. “Hybrid Nanocrystals of Small Molecules and Chemically Disordered Polymers” ACS Nano 2022, 16 (6), 8993-9003. Ledford, B. T.; Akerman, A. W; Sun, K.; Gillis, D. C.; Weiss, J. M.; Vang, J.; Willcox, S.; Clemons, T. D.; Sai, H.; Qiu, R.; Karver, M. R.; Griffith, J. D.; Tsihlis, N. D.; Stupp, S.I.; Ikonomidis, J. S.; Kibbe, M. R. “Peptide Amphiphile Supramolecular Nanofibers Designed to Target Abdominal Aortic Aneurysms” ACS Nano 2022, 16 (5), 7309-7322. Podlasek, C; Martin,S.; Deng J; Searl, T.;Ohlander,S.; Harrington,D.; Stupp,S.I.; Dynda D.; McVary,K. “Sonic Hedgehog Signaling in Primary Culture of Human Corpora Cavernosal Tissue from Prostatectomy, Diabetic, and Peyronie’s Patients” The Journal of Sexual Medicine 2022, 19 (8),1228-1242. Yuan, S.; Lewis, J.; Sai, H.; Weigand, S.; Palmer, L.; Stupp, S.I. “Peptide Sequence Determines Structural Sensitivity to Supramolecular Polymerization Pathways and Bioactivity” Journal of the American Chemical Society 2022,144 (36) 16512-16523.