Dilworth, Stephen - Middlesex University - Department of Natural Sciences

个人简介

1968-1974 Marsh Hill Boy's Grammar School, Birmingham 1973 A-Levels. 3 grade A, 1 grade B. (Biology, Chemistry, Physics and Mathematics) 1975-1978 St. John's College, Cambridge. B.A. (Hons.) Class: First. Subject: Natural Sciences 1981 M.A. 1978 - 1982 External PhD Student, Imperial College, London 1983 P.H.D. Thesis title: Polyoma virus T-antigens. Work performed at ICRF, LIF Branch.

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Novak, U., Dilworth, S.M., and Griffin, B.E. (1980). Coding capacity of a 35% fragment of the polyoma virus genome is sufficient to initiate and maintain cellular transformation. Proc. Natl. Acad. Sci. USA. 77 3278-3282. Magnusson, G., Nilsson, M.G., Dilworth, S.M., and Smolar, N. (1981). Characterization of Polyoma Mutants with Altered Middle and Large T-Antigens. Virol. 39 673-683. Dilworth, S.M., and Griffin, B.E. (1982). Monoclonal antibodies against polyoma virus tumor antigens. Proc. Natl. Acad. Sci. USA. 79 1059-1063. McCormick, F., Lane, D.P., and Dilworth, S.M. (1982). Immunological Cross-Reaction between Large T-Antigens of SV40 and Polyoma Virus. Virology 116 382-387. Dilworth, S.M. (1982). Protein kinase activities associated with distinct antigenic forms of polyoma virus middle T-antigen. EMBO Jl. 1 1319-1328. Ding, D.M., Dilworth, S.M., and Griffin, B.E. (1982). mlt Mutants of polyoma virus. J. Virol. 44 1080-1083. Dilworth, S.M., Cowie, A., Kamen, R.I., and Griffin, B.E. (1984). DNA binding activity of polyoma virus large tumor antigen. Proc. Natl. Acad. Sci. USA. 81 1941-1945. Dilworth, S.M., Hansson, H.A., Darnfors, C., Bjursell, G., Streuli, C.H., and Griffin, B.E. (1986). Subcellular localisation of the middle and large T-antigens of polyoma virus. EMBO Jl. 5 491-499. Dingwall, C., Dilworth, S.M., Black, S.J., Kearsey, S.E., Cox, L.S., and Laskey, R.A. (1987). Nucleoplasmin cDNA sequence reveals polyglutamic acid tracts and a cluster of sequences homologous to putative nuclear localization signals. EMBO Jl. 6 69-74. Dilworth, S.M., Black, S.J., and Laskey, R.A. (1987). Two Complexes That Contain Histones Are Required for Nucleosome Assembly In Vitro: Role of Nucleoplasmin and N1 in Xenopus Egg Extracts. Cell 51 1009-1018. Richardson, W.D., Mills, A.D., Dilworth, S.M., Laskey, R.A., and Dingwall, C. (1988). Nuclear Protein Migration Involves Two Steps: Rapid Binding at the Nuclear Envelope Followed by Slower Translocation through Nuclear Pores. Cell 52 655-664. Dingwall, C., Robbins, J., Dilworth, S.M., Roberts, B., and Richardson, W.D. (1988). The Nucleoplasmin Nuclear Location Sequence Is Larger and More Complex than That of SV 40 Large T Antigen. J. Cell Biol. 107 842-849. Lane, N.J., and Dilworth, S.M. (1989). Isolation and biochemical characterization of septate junctions: differences between the proteins in smooth and pleated varieties. J. Cell Sci. 93 123-131. Blanco, J., Millstein, L., Razik, M.A., Dilworth, S.M., Cote, C., and Gottesfeld, J. (1989). Two TF IIIA activities regulate expression of the Xenopus 5S gene families. Genes and Development. 3 1602-1612. Dingwall, C., Robbins, J., and Dilworth, S.M. (1989). Characterisation of the nuclear location sequence of Xenopus nucleoplasmin. J. Cell Sci. Suppl. 11 243-248. Dilworth, S.M. (1991). A perichromosomal region contains proteins phosphorylated during mitosis in Xenopus laevis cells. J. Cell Sci. 98 309-315. Robbins, J., Dilworth, S.M., Laskey, R.A., and Dingwall, C. (1991). Two Interdependent Basic Domains in Nucleoplasmin Nuclear Targeting Sequence: Identification of a Class of Bipartite Nuclear Targeting Sequence. Cell 64 615-623. Hopwood, N.D., Pluck, A., Gurdon, J.B., and Dilworth, S.M. (1992). Expression of XMyoD in early Xenopus laevis embryos. Development. 114 31-38. Forstova, J., Krauzewicz, N., Wallace, S., Street, A.J., Dilworth, S.M., Beard, S., and Griffin, B.E. (1993). Cooperation of Structural Proteins During Late Events in the Life Cycle of Polyoma Virus. J. Virol. 67 1405-1413. Dilworth, S.M., and Horner, V.P. (1993). Novel Monoclonal Antibodies That Differentiate Between the Binding of pp60c-src or Protein Phosphatase 2A by Polyoma Virus Middle T-Antigen. J. Virol. 67 2235-2244. Dilworth, S.M., Brewster, E.P., Jones, M.D., Lanfrancone, L., Pelicci, G., and Pelicci, P.G. (1994). Transformation by polyoma virus middle T-antigen requires the binding and tyrosine phosphorylation of Shc. Nature 367 87-90. Messerschmitt, A., Disela, C., Dilworth, S., Marti, A.G., and Ballmer-Hofer, K. (1996). Polyomavirus middle-T antigen lacking a membrane anchor sequence accumulates in the nucleus. J. Gen. Virol. 77. 17-26. Brewster, C.E.P., Glover, H.R., and Dilworth, S.M. (1997). Pp60c-src Binding to Polyomavirus Middle T-Antigen (MT) Requires Residues 185 to 210 of the MT Sequence. J. Virol. 71 5512-5520. Blaikie, P.A., Fournier, E., Dilworth, S.M., Birnbaum, D., Borg, J-P, and Margolis, B. (1997). The Role of the Shc Phosphotyrosine Interaction/Phosphotyrosine Binding Domain and Tyrosine Phosphorylation Sites in Polyoma Middle T Antigen-mediated cell transformation. J. Biol. Chem. 272 20671-20677. Senften, M., Dilworth, S., and Ballmer-Hofer, K. (1997). Multimerization of the Polyomavirus Middle-T Antigen. J. Virol. 71 6990-6995.