Vanner, Stephen - Queen's University - Department of Medicine

个人简介

Dr. Vanner received a undergraduate degree in Life Sciences and a concurrent MD and MSc degree from Queen’s University. After completing his Internal Medicine and Gastroenterology training at Queen’s and he carried out post doctoral research training in enteric neurophysiology at the Vollum Institute in Portland Oregon. Since returning to Queen’s University in 1991 he has been an attending staff in Gastroenterology at the Kingston General and Hotel Dieu Hospitals and cares for patients with gastrointestinal disorders in both the inpatient and outpatient departments. He performs a full range of endoscopic procedures including ERCP. He has subspecialty expertise in gastrointestinal motility disorders involving the lower GI tract including the small intestine, colon and anorectum and is director of the anorectal motility laboratory. He has an established translational research program that examines mechanisms underlying pain signaling and motility in the gastrointestinal tract.

研究领域

Peripheral pain mechanisms underlying irritable bowel syndrome and inflammatory bowel diseas Synthetic stool transplants for treating C. difficile colitis and potential “ecosystem therapeutics” for other disorders such as IBD, IBS and others (Petrof PI) Colon cleansing kits for colonoscopy Key signaling molecules and targets of interest: mast cell and non mast cell proteases endogenous opioids in chronic inflammation FODMAP diets (low CHO) diets and their effect on the microbiome Human models of study (current or potential): irritable bowel syndrome – indirect studies of microbiome using breath testing and combined Tc99 scintography; baraostat measurements of rectal sensory thresholds DNA methylation studies of colonic biopsies from colon cancer screening patients (Will King PI) fecal probiotic for treatment of C. difficile (Elaine Petrof PI) electrophysiology recordings from the human colon and the effects of stress hormones (joint program GIDRU members and General Surgery) GIDRU is developing a “human research laboratory” for comprehensive and capacity studies of humans Animal models of study (existing or desired): post infectious IBS model – self limiting colitis induced by Citrobacter rodentium (a model of Human E. coli infection) combined with chronic stress – patch clamp, multi-unit afferent recordings, plus in vivo sensory threshold measurements with visceromotor reflexes acute and chronic models of IBD – TNBS, DSS (same techniques as 1.) Biobanking of human samples (existing or desired): colonic biopsies from all disease from upper and lower GI tract; currently studying irritable bowel syndrome, IBD, and colon polyp/cancer patients stool samples for microbiome analysis; currently studying C. difficile colitis (Petof PI) access to blood and urine samples on all of above

近期论文

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Epithelial expression and function of trypsin-3 in irritable bowel syndrome. Rolland-Fourcade C, Denadai-Souza A, Cirillo C, Lopez C, Jaramillo JO, Desormeaux C, Cenac N, Motta JP, Larauche M, Taché Y, Berghe PV, Neunlist M, Coron E, Kirzin S, Portier G, Bonnet D, Alric L, Vanner S, Deraison C, Vergnolle N. Gut. 2017 Jan 17. pii: gutjnl-2016-312094. doi: 10.1136/gutjnl-2016-312094. [Epub ahead of print] PMID: 28096305 Free Article Similar articles Select item 28007748 Emerging Studies of Human Visceral Nociceptors. Reed DE, Vanner SJ. Am J Physiol Gastrointest Liver Physiol. 2016 Dec 22:ajpgi.00391.2016. doi: 10.1152/ajpgi.00391.2016. [Epub ahead of print] PMID: 28007748 Similar articles Select item 27590998 Stress activates pronociceptive endogenous opioid signalling in DRG neurons during chronic colitis. Guerrero-Alba R, Valdez-Morales EE, Jimenez-Vargas NN, Lopez-Lopez C, Jaramillo-Polanco J, Okamoto T, Nasser Y, Bunnett NW, Lomax AE, Vanner SJ. Gut. 2016 Sep 2. pii: gutjnl-2016-311456. doi: 10.1136/gutjnl-2016-311456. [Epub ahead of print] PMID: 27590998 Similar articles Select item 27144634 Rome IV Diagnostic Questionnaires and Tables for Investigators and Clinicians. Palsson OS, Whitehead WE, van Tilburg MA, Chang L, Chey W, Crowell MD, Keefer L, Lembo AJ, Parkman HP, Rao SS, Sperber A, Spiegel B, Tack J, Vanner S, Walker LS, Whorwell P, Yang Y. Gastroenterology. 2016 Feb 13. pii: S0016-5085(16)00180-3. doi: 10.1053/j.gastro.2016.02.014. [Epub ahead of print]