Donnell, Denis O - Queen's University - Department of Medicine

个人简介

Denis E. O’Donnell, MB, BCh., (NUI), MD (NUI), FRCP(I), FRCP(C) is a Professor of Medicine, with cross appointments to the Departments of Biomedical & Molecular Sciences (Physiology), Rehabilitation Medicine and Kinesiology & Health Studies, Queen’s University, Kingston, Ontario, Canada. He is a Clinician Scientist and past Chair of the Division of Respiratory and Critical Care Medicine and Director of the Respiratory Investigation Unit at Queen’s. He completed clinical research fellowships in Respirology at TrinityCollege, Dublin, and at the University of Manitoba (1984-1988), where he completed a doctoral thesis in medicine on the topic “Mechanisms of Dyspnea in COPD” in 1988. Dr. O’Donnell’s main research focus is clinical integrative physiology and specifically, exercise pathophysiology and mechanisms and management of dyspnea in respiratory disorders. His main clinical focus is COPD and pulmonary rehabilitation. Dr. O’Donnell had a leadership role (Chair) in the development of best practice guidelines for the management of COPD in Canada. He has been a senior author in over 260 scientific publications. He has co-edited a book on Dyspnea, now in its third edition. He has lectured extensively on these topics both at a national and international level. He has been the recipient of the Basmajian award for Excellence in Biomedical research at Queen’s University. He held a Career Scientist Award from the Ontario Ministry of Health from 1994 to 2004. He gave the American College of Chest Physicians Distinguished Scientist Honour Lecture in 2005, the Trudeau Lecture for the New York Thoracic Society in 2007, the Jean Jacques Gauthier Award and Honour Lecture, University of Montreal and the John Rankin Visiting Professor and Honour Lecture, University of Madison, Wisconsin in 2008. In 2012 he received an award for Excellence in Research in Respiratory Physiology by the Association for Respiratory Technology & Physiology (ARTP) in the United Kingdom. He serves on several national and international scientific panels on respiratory diseases and sits on the Editorial Boards for CHEST, Journal of Applied Physiology, Journal of COPD, the International Journal of COPD, and is an Associate Editor of the Canadian Respiratory Journal. He is the Past President of the Canadian Thoracic Society and is a member of the Institute Advisory Board (IAB) for the Canadian Institutes of Health Research (Circulatory and Respiratory Health). He is currently the National Canadian Delegate for the European Respiratory Society. Contact: 102 Stuart Street, Kingston, ON K7L 3N6 Email: odonnell@queensu.ca Phone: 613.548.2339 Fax: 613.549.1459 Clinical Interests: General Respirology COPD Pulmonary Rehabilitation Clinical Appointments: G.F.T. Kingston General Hospital Consultant: Hotel Dieu Hospital Providence Continuing Care, St. Mary's on the Lake Academic Interests: Director, Respiratoru investigation Unit Queen's University http://www.queensu.ca/riu/index.html Exercise physiology Control of breathing in cardiopulmonary disease Lung mechanics in COPD Mechanisms and management of dyspnea in cardriopulmonary disease Administrative Appointments: Professor, Department of Medicine Professor, Department of Physical Medicine and Rehabiliation Professor, Department of Physiology Professor, School of Kinesiology and Health Studies

研究领域

Mechanisms and management of dyspnea in chronic pulmonary conditions Respiratory control, respiratory muscle function and mechanics during exercise in health and disease Effects of aging, sex/gender, obesity, pregnancy, skeletal muscle deconditioning on exercise performance, cardiopulmonary responses and respiratory sensation Small airway and pulmonary microvascular dysfunction in patients with early or mild COPD Translational Research Physiological studies on the impact of supplemental oxygen, non-invasive ventilatory assistance, nebulized Furosemide, nebulized opiates, surgical bullectomy on improving dyspnea and exercise performance in patients with COPD. Clinical trials on the efficacy of new bronchodilators and anti-inflammatory agents in patients with COPD with particular focus on the outcomes of dyspnea and exercise endurance.

近期论文

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O'Donnell DE, Webb K. Exertional breathlessness in patients with chronic airflow limitation: the role of lung hyperinflation. Am Rev Respir Dis 1993: 48(5):1351-1357. Loughneed MD, Webb K, O'Donnell DE. Breathlessness during induced hyperinflation in asthma: the role of the inpiratory threshold load. Am J Respir Crit Care Med 1995; 152(3):911-920. O'Donnell DE, Bertley J, Webb KA, Conian AA. Mechanisms of relief of extertional breathlessness following unilateral bullectomy and lung volume reducation surgery in advanced chronic airflow limitation. Chest, 1996; llo: 18-27. O'Donnell DE, Chau LL, Bertley J, Webb KA. Qualitative aspects of exertional breathlessness in chronic airflow limition: pathophysiological mechanisms. Am J Respir Crit Care Med 1997: 155:190-115. O'Donnell DE, Chau LKL, Webb KA. Qualitative aspects of exertional dyspnea in interstitial lund disease. J Appl Physiol 1998; 84: 2000-2009. O'Donnell DE, McGuire M, Samis L, Webb KA. Effects of general exercise training on ventilatory and peripheral muscle strength and endurance in chronic airflow limitation. Am J Respor Crit Care Med 1998: 157:1489-1497. O'Donnell DE, Lam M, Webb KA. Measurement of exertional symptoms, dynamic hyperinflation and exercise endurance in COPD. Am J Respir Crit Care Med 1998;158:1557-1565. O'Donnell DE, D'Arsigny C, Raj S, Abdollah, Webb KA. Ventilatory assistance improves exercise endurance in patients with stable congestive heart failure. Am J Respir Crit Care Med 1999;160:1804-1811. O'Donnell DE, Hong HH, Webb KA. Effects of chest wall restriction and deadspace loading on dyspnea and exercise tolerance in healthy normals. J Appl Physiol 2000;88:1859-1869. O'Donnell DE, Revill SK, Webb KA. Dynamic hyperinflation and exercise intolerance in COPD. Am J Respir Crit Care Med 2001:164:770-777. Lougheed MD, Flannery J, Webb KA, O'Donnell DE. Respiratory sensation and ventilatory mechanics during induced bronchoconstriction in spontaneously breathing low cervical quadriplegia. Am J Respit Crit Care Med 2001;166:370-376. O'Donnell DE, D'Arsigney C, Fitzpatrick M, Webb Ka. Exerice hypercapnia in advanced COPD: the role of lung hyperinflation. Am J Respir Crit Care Med 2002:166:663-668 [with accompanying editorial] O'Donnell DE, Voduc N, Fitzpatrick M, Webb KA. Effect of salmeterol on the ventilatory response to exercise in COPD. Eur Respir 2004;24:86-94. O'Donnell D, Fluge T, Gerken F, Hamilton A, Webb K, Agauilaniu B, Make B, Magnussen H. Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD. Eur Respir J 2004; 23:832-840. Jensen D, Wolfe La, Slatkovska L, Webb KA, Davies GAL, O'Donnell DE. Effects of human pregnancy on the ventilatory chemoreflex response to carbon dioxide. Am J Physiol: Regulatory, integrative and Comparative Physiology 2005;288:1369-1375. Parker CM, Voduc N, Aaron SD, Webb KA, O'Donnell DE. Physiological changes during symptom recovery from moderate exacerbation of COPD. Eur Respir J 2005;26(3):420-428. [with accompanying editorial]