个人简介

MSci, Chemistry - King's College, London 2004 PhD, Biomedical Engineering - Imperial College, London 2007 Post Doctoral Fellow, Chemistry - UNC at Chapel Hill, 2007-2011

研究领域

Bio-analytical/Neurochemistry/Nano-farication/Bio-sensors/Micro-electrodes

In the Hashemi Lab we are interested in developing novel tools for detecting molecules in the brain in order to characterize several aspects of brain function. Our research is divided into four areas: Cell Receptor Based Bio-sensing Biosensors employ a biological molecule to specifically 'recognize' and quantify molecules of interest that are not inherently electro-active. We are combining intact membrane bound neurotransmitter receptors, grown on 'designer' cells, with patch clamp and potentiometry techniques to produce a fast, sensitive, and selective recognition method for our biosensors. These sensors are directly implanted into the brain tissue and provide real-time, online measurements of the brain's molecules. Nano-fabricated Conductive Wires In order to probe the brain's chemistry, we need to develop devices small enough to sample the brain's chemical communication junctions, synapses, without damaging them. These junctions are typically 10-100 nm in length. In collaboration with SSIM at Wayne State (Smart Sensors and Integrated Microsystems), we are designing and characterizing nano-dimension conductive wires as the transduction method of our biosensors. Neuro-chemical Mechanisms of Depression Depression is a debilitating mental disorder that affects 12% of the US population. Imbalances in the serotonergic system in the brain are strongly implicated in depression but the exact mechanisms remain unclear. We are interested in understanding the effect of antidepressants on brain serotonin levels. An acute antidepressant dose causes large increases in brain serotonin levels (Figure 1) however, relief from depression symptoms often comes after a chronic treatment period. We are using Fast-Scan Cyclic Voltammetry (FSCV) to monitor serotonin release and uptake in the intact brain in order to study this phenomenon.

近期论文

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Hashemi P, Dankoski EC, Petrovic J, Keithley RB, Wightman RM (2009) Voltammetric detection of 5-hydroxytryptamine release in the rat brain. Anal Chem 81:9462-9471. Hashemi P, Bhatia R, Nakamura H, Dreier JP, Graf R, Strong AJ, Boutelle MG (2009) Persisting depletion of brain glucose following cortical spreading depression, despite apparent hyperaemia: evidence for risk of an adverse effect of Leao's spreading depression. J Cereb Blood Flow Metab 29:166-175. Hashemi P, Caesar K, Douhou A, Bonvento G, Boutelle MG, Walls AB, Lauritzen M (2008) Glutamate receptor-dependent increments in lactate, glucose and oxygen metabolism evoked in rat cerebellum in vivo. J Physiol 586:1337-1349. Hashemi P, Wightman RM (2007) Paying attention with the latest technology. Neuron 56:4-5.