Anastassiades, Tassos - Queen's University

个人简介

Dr. Tassos Anastassiades is a Clinician Scientist and an Emeritus Professor of Medicine. His clinical training was at McGill at the Royal Victoria Hospital and he did most of his PhD work at the Rockefeller University in New York. He serves as Head of the Division of Rheumatology and has provided local and National leadership in Arthritis for a number of years. His main clinical and teaching interest is currently in osteoporosis. His Laboratory research is in connective tissue metabolism. The emphasis is on repair of damaged cartilage and bone. He has developed chemically modified glucosamines by changing the N-acetyl group to other moieties. He showed that one of these compounds demonstrated pronounced protective effects on the bones of animal models of destructive arthritis and of osteoporosis. These modified glucosamine compounds can be positioned somewhere between pharmaceuticals and nutriceuticals and appear to have very low toxicity. Recently his attention has turned to chemically modifying hyaluronic acid, the giant, ubiquitous molecule of connective tissues. Surprisingly, these modified hyaluronic acid compounds, which are of relatively low molecular weight, show a striking ability to reduce the production of pro-inflammatory cytokines. Both the modified glucosamines and hyaluronic acid compounds have potentially multifaceted translational applications. Dr. Anastassiades is also involved in observational research in osteoporosis and is the Director for the Kingston Centre of the Canadian Multicentre Osteoporosis Study (CaMOS), which is a CIHR-funded initiative now in its 17th year.

研究领域

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Animal models in arthritis and osteoporosis for testing compounds of interest. Laboratory work on the hyaluronic acid compounds including assessing their anti-inflammatory potential in vitro. Work with human sera and other biological fluids from patients with chronic inflammatory conditions and controls. Isolation of hyaluronic acid and testing for inflammatory properties and effects of our synthetic compounds. This project is currently in development. Epidemiology projects in osteoporosis utilizing the CaMOS data base. A focus in the Kingston CaMOS site has been on quality of life measures. Clinical and radiological assessment of hand X-rays for chronic inflammatory disease and osteoporosis (Combined Cortical Thickness): A simple quantitative method also providing insight into pathogenesis and function.