Smith, Graeme N - Queen's University - Department of Biomedical and Molecular Sciences

个人简介

Dr. Smith completed a combined MD/PhD at the University of Western Ontario in 1992 under the supervision of Dr. John Patrick. He subsequently obtained his FRCSC in Obstetrics & Gynecology at Queen’s University in 1997 and completed sub-specialty training in Maternal-Fetal Medicine at the University of Toronto in 1999 before joining the faculty at Queen's. Dr. Smith is a member of the Maternal-Fetal Medicine Division and is the Professor and Head of the Department of Obstetrics & Gynecology at Queen’s University and is cross-appointed to the Department of Biomedical and Molecular Sciences and Imaging Services. Dr. Smith divides his time between high-risk obstetrics, clinical/basic science research and as the director of the Clinical Investigator Program for the School of Medicine, Faculty of Health Sciences at Queen’s University.

研究领域

Dr. Smith runs the Queen's University Perinatal Research Unit which has a basic science laboratory and a clinical research/clinical trials group. The current focus of both his basic and clinical research is on adverse obstetrical events, specifically related to the etiology, outcomes and potential therapies for pre-eclampsia. Current research themes include: Examining adverse pregnancy outcomes as a marker of future maternal health. Dr. Smith has developed The MotHERS Program (Mothers Health Education, Research and Screening) and its website (www.themothersprogram.ca) to improve maternal health and outcomes. Exploring the molecular, haemodynamic and morphological effects of carbon monoxide gas inhalation on the utero-placental environment. Dr. Smith has active research projects aimed at elucidating the role of carbon monoxide exposure and maternal risk for, and symptomatic presentation of pre-eclampsia. Research Funding History Canadian Institutes of Health Research; Canadian Federation for Women’s Health; Heart and Stroke Foundation; Physician’s Services Inc., Clinical Teachers' Association of Queen's University. Prospective Research Students For inquiries regarding research in the Smith Lab, please address correspondences to both Dr. Graeme Smith at gns@queensu.ca and our lab manager Nicki Peterson at nicki.peterson@queensu.ca.

近期论文

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Murphy MSQ, Bytautiene E, Saade G, Smith GN. (2015) Alterations to the maternal circulating proteome after pre-eclampsia. American Journal of Obstetrics and Gynecology. Available online: doi:10.1016/j.ajog.2015.10.008 Murphy MSQ, Tayade C, Smith GN. (2015) Evidence of inflammation and predisposition toward Metabolic Syndrome after pre-eclampsia. Pregnancy Hypertension. Available online: doi: 10.1016/j.preghy.2015.09.007 McRae K E, Davies GAL,Easteal RA, Smith GN. (2015) Creation of plastinated placentas as a novel teaching resource for medical education in obstetrics and gynaecology. Placenta. 36 (9): 1045 - 1051. Murphy MSQ, Seaborn GEJ, Redfearn DP, Smith GN. (2015) Reduced heart rate variability and altered cardiac conduction after pre-eclampsia. PlosOne. DOI: 10.1371/journal.pone.0138664 Murray EKI, Murphy MSQ, Smith GN, Hopman WM, Othman M, Graham CH. (2015) Thromboelastography identifies cyclic haemostatic variations in healthy women using oral contraceptives. Thrombosis Research. . Available online: doi.org/10.1016/j.thromres.2015.08.011 Murphy MSQ, Casselman RC, Tayade C, Smith GN. (2015) Differential expression of plasma miRNA in pre-eclamptic patients at delivery and one year postpartum. American Journal of Obstetrics and Gynecology. 213(3):367.e1-9 doi:10.1016/j.ajog.2015.05.013 Rodger,M.A., M.C.Walker, G.N.Smith, P.S.Wells, T.Ramsay, N.J.Langlois, N.Carson, M.Carrier, R.Rennicks White, S.Shachkina, S.W.Wen. Is thrombophilia associated with placenta-mediated pregnancy complications? A prospective cohort study. J Thromb Haemost 2014 Apr;12(4):469-78.3. Venditti CC, Smith GN.Involvement of the heme oxygenase system in the development of preeclampsia and as a possible therapeutic target. Womens Health (Lond Engl). 2014 Nov;10(6):623-43. doi: 10.2217/whe.14.54. Murphy MS, Vignarajah M, Smith GN. Increased microvascular vasodilation and cardiovascular risk following a pre-eclamptic pregnancy. Physiol Rep. 2014 Nov 26;2(11). pii: e12217. doi: 10.14814/phy2.12217. Print 2014 Nov 1. Venditti CC, Casselman R, Young I, Karumanchi SA, Smith GN. Carbon monoxide prevents hypertension and proteinuria in an adenovirus sFlt-1 preeclampsia-like mouse model. PLoS One. 2014 Sep 9;9(9):e106502. doi: 10.1371/journal.pone.0106502. eCollection 2014. Wen, S.W., J.Champagne, R.Rennicks White, W.I.Fraser, G.N.Smith, D.A.Fergusson, M.C.Walker. Effect of folic acid supplementation in pregnancy on preeclampsia: the folic acid clinical trial (FACT) study. J Pregnancy 2013 doi 10.1155/2013/294312 M.Cussimano, J.Pudwell, M.Roddy, C.K.J. Cho, G.N.Smith. The Maternal Health Clinic: An initiative for cardiovascular risk reduction in women with pregnancy-related complications. Am J Obstet Gynecol 2013 Dec 4 doi 10.1016/j.ajog.2013.12.001 Luo, Z.C., P.Julien, S.Q.Wei, F.Audibert, G.N.Smith, W.D.Fraser. Plasma cotinine indicates an increased risk of preeclampsia in previous and passive smokers. Am J Obstet Gynecol 2013 Oct 2. pii: S0002-9378(13)01034-X. doi: 10.1016/j.ajog.2013.09.041. S.Nascimento, J.Pudwell, F.Surita, K.Adamo, G.N.Smith. The effect of physical exercise strategies on weight loss in postpartum women: a systematic review and meta-analysis. Int J Obes (Lond). 2013 Sep 19. doi: 10.1038/ijo.2013.183. [Epub ahead of print] C.Venditti, L.Adamson, M.S.Q.Murphy, J.Sled, G.N.Smith. Chronic carbon monoxide inhalation during pregnancy augments uterine artery blood flow and uteroplacental vascular growth in mice. Am J Physiol 2013 Aug 28. [Epub ahead of print] 7. Ray, J.G., A.J.McGeer, J.M.Blake, G.Lebovic, G.N.Smith, M.H.Yudin Peripartum outcomes: non-adjuvanted v. adjuvanted H1N1 vaccination. CMAJ. 2014 Feb 4;186(2):137. G.N.Smith, J.Pudwell, M.Roddy. 2013: The Maternal Health Clinic: A new window of opportunity for early heart disease risk screening and intervention for women with pregnancy complications. JOGC 35(9):831-839. G.N.Smith, G.Saade. Pregnancy as a window to future health: The development of complications in pregnancy provides a new window of opportunity for early heart disease risk screening and intervention for women. Society for Maternal-Fetal Medicine, 2013; www.smfm.org/attachedfiles/pregwindowSMFM513.pdf (pg 1-8). Highlighted ScienceDaily July 1, 2013. 10. Sprague, A., S.I.Dunn, D.B.Fell., J.Harold, M.C.Walker, S.Kelly, G.N.Smith (2013) Measuring Quality in Maternal-Newborn Care: Developing a Clinical Dashboard. J Obstet Gynaecol Can; Jan 35(1):29-38. Murphy, MSQ, RC Casselman, GN Smith (2013) Postpartum alterations in circulating endothelial progenitor cells in women with a history of pre-eclampsia. Pregnancy Hypertension. Wen S, H.Tan, R.Xie, G.N.Smith, M.Walker. (2012) A pre-conception cohort to study preeclampsia in China: Rationale, study design, and preliminary results. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2012 Nov;37(11):1081-7. doi: 10.3969/j.issn.1672-7347.2012.11.001. Smith GN, J.Pudwell, M.Walker and S.W.Wen for the PE-NET (2012) Risk estimation of metabolic syndrome at one and three years after a pregnancy complicated by preeclampsia. J Obstet Gynaecol Can. 2012 Sep;34(9):836-41. (PE-NET: CIHR FMI 63194 and HSFC PG-03-0175-PE-NET) Smith GN, J.Pudwell, M.Walker and S.W.Wen for the PE-NET (2012) Ten year, thirty year and life-time risk estimates of cardiovascular disease following a pregnancy complicated by pre-eclampsia. J Obstet Gynaecol Canada, 34(9):830-835. (PE-NET: CIHR FMI 63194 and HSFC PG-03-0175-PE-NET) Smith GN, J.Pudwell, M.Walker and S.W.Wen for the PE-NET. (2012) A history of pre-eclampsia identifies women with cardiovascular risk factors including the metabolic syndrome. Follow up of the Pre-Eclampsia New Emerging Team longitudinal prospective cohort. J Obstet Gynaecol Canada 34(9):836-841. (PE-NET: CIHR FMI 63194 and HSFC PG-03-0175-PE-NET) Yanfang, G., G.N.Smith, S.W.Wen, M.C.Walker. (2012) Folate Metabolism and Preeclampsia. Fetal and Maternal Medicine Review 23:2, May 2012.