Siemens, D. Robert - Queen's University - Department of Biomedical and Molecular Sciences

个人简介

Our research focuses on certain aspects of cancer progression and cancer treatment. These studies look at certain aspects of the micro-environment of tumor cells and how this may be altered to improve existing treatments, including chemotherapy and radiotherapy. We also are interested in the development of novel drug therapies for the treatment of cancer.

研究领域

Our research focuses on certain aspects of cancer progression and cancer treatment. These studies look at certain aspects of the micro-environment of tumor cells and how this may be altered to improve existing treatments, including chemotherapy and radiotherapy. We also are interested in the development of novel drug therapies for the treatment of cancer. Sources of Research Funds: Clare Nelson Bequest; U.S. Army Medical Research and Materiel Command; Prostate Cancer Research Foundation.

近期论文

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1. Friederiksen LJ, Siemens DR, Heaton JPW, Maxwell LR, Adams MA, Graham CH: The role of nitric oxide in hypoxia-induced chemoresistance in prostate cancer. Journal of Urology, 170: 1003-1007, 2003. 2. Siemens, D.R., Crist S., Austin, J.C., Tartaglia, J., Ratliff, T.L.: Comparison of viral vectors: gene transfer efficiency and tissue specificity in an orthotopic murine bladder cancer model. Journal of Urology, 170: 979-984, 2003. 3. Siemens, D.R., Morales, A.M., Emerson, L., Johnston, B.: A comparative analysis of rapid urine tests for the diagnosis of suspicious upper tract lesions. Canadian Journal of Urology, 10(1): 1694-98, 2003. 4. Siemens, D.R., Ratliff, T.L: Vaccines in Urologic Malignancy. Urological Research, 29:152-162, 2001 Elsey B.D., Siemens, D.R., Ratliff, T.L. and Lubaroff, D.M.: Immunization with type 5 adenovirus recombinant for a tumor antigen in combination with recombinant canarypox viraus (ALVAC) cytokine gene delivery induces destruction of established prostate tumors. International Journal of Cancer, 94(6):842-9, 2001. 6. Siemens, D.R., Austin, J.C., See, W.A., Tartaglia, J., Ratliff, T.L.: Evaluation of gene transfer efficiency by viral vectors to murine bladder epithelium. Journal of Urology, 165: 667, 2001 7. Siemens, D.R., Iwasawa T., Austin, J.C., See, W.A., Hedican, S.P., Tartaglia, J., Cohen M., Rodgers, J., Williams R.W., Ratliff, T.L.: Biomarker distribution after injection in the canine prostate: implications for gene therapy. BJU International, 86: 1076, 2000. 8. Siemens, D.R., Elzey, B.D., Lubaroff, D.M., Bohlken, C., Jensen R.J., Swanson A.K., Ratliff, T.L.: Restoration of the ability to generate CTL in mice immune to adenovirus by delivery of virus in a collagen-based matrix. Journal of Immunology, 166: 731, 2000 9. Siemens, D.R., Austin, J.C., Hedican, S.P., Tartaglia, J., Ratliff, T.L.: Viral delivery in a gelatin sponge matrix enhances gene expression and antitumor activity in a murine prostate cancer model. JNCI, 92 (5): 403-412, 2000.