Flavin, Michael - Queen's University - Department of Biomedical and Molecular Sciences

个人简介

Dr. Flavin is interested in clinical studies which apply new basic science findings to neurodevelopmental impairment stemming from fetal and neonatal events such as brain inflammation, ischemia, and glucose deprivation.

研究领域

In some children with cerebral palsy there is evidence of peri-natal exposure to a pro-inflammatory state. Dr. Flavin is interested in the role of glial cells in ischemic and pro-inflammatory settings during early brain development. There are two current studies: a search for suitable inhibitors of microglial activation and an examination of the role of fever in fetal brain damage after a pro-inflammatory stimulus. He uses cell culture and in vivo systems. Sources of Research Funds: Dr. Flavin is funded by the Heart and Stroke Foundation for the cell interactions and tPA studies. The oligodendrocyte studies are locally funded

近期论文

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1. Flavin, M.P. Glial-neuronal cross-talk in neurodegeneration. IN: Glia and inflammation in neurodegenerative disease. Eds. Yenari MA and Giffard RG. 2006. Publishers: Nova Science. 2. Flavin, M.P., Ho, L.T. Microglial tissue plasminogen activator (tPA) triggers neuronal apoptosis in vitro. Glia 29:347-354, 2000. 3. Zhao, G., Flavin, M.P. Differential sensitivity of rat hippocampal and cortical astrocytes to oxygen glucose deprivation injury. Neuroscience. Letters 285:177-180, 2000. 4. Flavin, M.P., Zhao, G. Tissue plasminogen activator protects hippocampal neurons from oxygen-glucose deprivation injury. Journal of Neuroscience Research 63:388-394, 2001. 5. Zhao, G., Reynolds, J.N., Flavin, M.P. Temporal profile of tissue plasminogen activator (tPA) and inhibitor expression after transient focal cerebral ischemia. NeuroReport Sept 15; 14(13) 1689-92, 2003.