个人简介
Dr. Othman obtained her Medical degree, completed 3-years residency and received clinical training in Haematology/ Haemostasis at Mansoura University, Egypt. This training covered basic routine and specialized clinical/laboratory investigations related to the following fields: haematology, immunology, microbiology and clinical chemistry with a particular focus on Clinical/ Laboratory Haemostasis and related research. This was followed by an MSc at the same university. She obtained her PhD and received Clinical and Molecular Biology research training at Southampton university, UK . Dr. Othman completed a 3-year postdoctoral fellowship training at Dr. David Lillicrap's expert research Lab, Department of Pathology and Molecular Medicine, Queen's University and was an adjunct faculty at the same department for 2 years prior to joining DBMS. Her major research interests include: Molecular genetics and diagnosis of Platelet type von Willebrand disease and the role of platelet GPIb alpha protein in haemostais and beyond, Thromboelastography as a global haemostatic test in haematological and non haematological diseases, Coagulopathy in prostate cancer and pregnancy complications as well as Platelet- Adenovirus interactions.Education
1990 MD (MB BCh), Mansoura University, Egypt
1993 Residency in Clinical Pathology, Mansoura University, Egypt
1995 MSc in Clinical Pathology, Mansoura University, Egypt
2003 PhD in Pathology, Southampton University, Southampton, UK
2005 Post doctoral fellowship training, Queen’s University, CA
研究领域
Platelet type- von Willebrand disease (PT-VWD):
Mutations in the platelet GP1BA gene causing this rare autosomal dominant bleeding disorder. I have identified and characterized a novel mutation in the macroglycopeptide region of the GP1BA gene in three members of a British family with PT-VWD phenotype and has coordinatd an international project for the differential identification between the two closely similar disorders type 2B and PT-VWD based on genetic analysis . The results of this project is now published. For more info on pervious and ongoing related work please refer to http://www.pt-vwd.org/. We are currently investigating the bleeding phenotype in patients with PT-VWD worldwide, participating in international study using flowcytometry to differentiate type 2B VWD form PT-VWD as well as conducting a novel focused group of investigation in the PT-VWD mouse model including assessing the bleeding phenotype using thromboelastography during pregnancy and in response to infection as well as investigating novel treatment modalities.
Thromobelastography (TEG) studies:
We have demonstrated a wide inter and intra individual variations in the TEG pattern in hemophilia A dogs. We have also shown that acute exercise improves the global hemostatic efficacy in those hemophilic animals as shown by the changes in their TEG patterns. We evaluated the role of thromboelastography as a sensitive hemostatic tool to monitor the rFVII treatment in hemophilia A dogs. We are also investigating the role of TEG in determining haemostatic abnormalities in two medical conditions: Obstructive sleep apnea (OSA) and pre eclampsia. We are studying the TEG changes following inspiratory occlusion in anaesthetized rats to model OSA and also in LPS- treated pregnant rats to model pregnancy complication. We are currently investigating the effect of CPAP treatment on hypercoagulability in patients with severe OSA using a cross blinded study.
Prostate cancer and thrombosis:
We have recently extended our TEG studies to include prostate cancer investigating the role of this sensitive global assay in assessing hypercoagulability in these patients as well as novel markers that help risk stratification and guidance to anticoagulant prophylaxis. These studies are performed in collaboration with Dr. Rob Siemens. Currently we are studying the role of hypoxia in tumor microenvironment as well as the ADT therapy in thromboembolic risk in these patients.
Platelet- adenovirus interactions
We investigated the mechanism of acute thrombocytopenia that follows adenovirus administration and approaches to prevent this adverse effect. We have demonstrated a novel expression of CAR on human platelets and a critical role for the platelet P-selectin and the VWF protein in mediating adenovirus induced platelet clearance and currently studying the detailed adenovirus/ platelet interactions (binding/ internalization) both in vitro using human platelets and in vivo using mice platelets. We have studied the interaction of platelets with inert particles and compared it to adenovirus including the effect on platelet aggregation and the role of platelet membrane receptors as well as the ultrastructure of platelets in response to adenovirus. We are currently investigating approaches to reduce the adenovirus induced thrombocytopenia and their effect on virus liver transduction.
近期论文
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- Alkhiary W, Azzam H, Yossof MM, Aref S, Othman M, El-Sharawy S. Association of Hemostatic Gene Polymorphisms With Early-Onset Ischemic Heart Disease in Egyptian Patients.Clin Appl Thromb Hemost. 2015 Feb 18.
- Maceachern K, Kaur H, Toukh M, Mumal I, Hamilton A, Scovil S, James P, Elbatarny HS, Othman M. Comprehensive Evaluation of Hemostasis in Normal Women: Impact on the Diagnosis of Mild Bleeding Disorders. Clin Appl Thromb Hemost. 2015 Jan;21(1):72-81.
- Arbelaez A, Niemann J, Freney R, Othman M, Emsley J, Mohammed S, Favaloro EJ.'Bleeding in the Jungle'. Am J Hematol. 2015 Apr 8.[Epub ahead of print]
- Kaur H, Corscadden K, Lott C, Elbatarny HS, Othman M. Bromelain has paradoxical effects on blood coagulability: a study using thromboelastography. Blood Coagul Fibrinolysis. 2014 Dec 16. [Epub ahead of print]
- Kaur H., Ozelo M, Scovil S, James P, Othman M. Systematic analysis of bleeding phenotype in PT-VWD compared to type 2B VWD using an electronic bleeding questionnaire. Clin Appl Thromb Hemost. June 2014. In press.
- Toukh M, Siemens DR, Black A, Robb S, Leveridge M, Graham CH, Othman M. (2014)Thromboelastography identifies hypercoagulablilty and predicts thromboembolic complications in patients with prostate cancer. Thromb Res. 133(1), 88-95.
- Othman M, Emsley J. Platelet- Type von Willebrand Disease: Toward an improved understanding of the " Sticky situation". Semin Thromb Hemost. 2014 Feb 4
-Othman M, Kaur H, Emsley J. Platelet-type von Willebrand disease: new insights into the molecular pathophysiology of a unique platelet defect. Semin Thromb Hemost. 2013 Sep;39(6):663-73
-Scepansky E, Othman M, Smith H.Aquired von Willebrand syndrome with a type 2B phenotype: Diagnostic and therapeutic dillemma. Acta Haematol. 2013 Nov 28;131(4):213-217.
-Othman M.Rare bleeding disorders: genetic, laboratory,clinical and molecular aspects. Preface . Semin Thromb Hemost. 2013 Sep;39(6):575-8.
-Toukh M, Ozelo MC, Angelillo-Scherrer A, Othman M. A novel use of thromboelastography in type 2B von Willebrand disease. International Journal of Laboratory Haematology. In press
-Toukh M, Gordon SP, Othman M. Construction Noise Induces Hypercoagulability and Elevated Plasma Corticosteroids in Rats.Clin Appl Thromb Hemost. 2013 Apr 8.
- Enayat S, Ravanbod S, Rassoulzadegan M, Jazebi M, Tarighat S, Ala F, Emsley J, Othman M. A novel D235Y mutation in the GP1BA gene enhances platelet interaction with von Willebrand factor in an Iranian family with platelet-type von Willebrand disease. Thromb Haemost. 2012;108(5).
-Gupalo E, Kuk C, Qadura M, Buriachkovskaia L, OthmanM. Platelet - adenovirus versus inert particles interaction: Effect on aggregation and the role of platelet membrane receptors. Platelet- 2012, July 19. [Epub ahead of print]
-Toukh M, Pereira EJ, FalconBJ, Liak C, Lerner M, HopmanWM, Iscoe S, Fitzpatrick MF , Othman M. Continuous Positive Airway Pressure Reduces Hypercoagulability, as Assessed by Thromboelastography, in Severe Obstructive Sleep Apnea. Resp Phys and Neurobiol J- 2012 Jul 5. [Epub ahead of print].
-Cotechini T, Othman M, Graham CH. Nitroglycerin prevents coagulopathies and foetal death associated with abnormal maternal inflammation in rats. Thromb Haemost. 2012 Jan 25;107(4).
-Falcón BJ, Cotechini T, Macdonald-Goodfellow SK, Othman M, Graham CH. Abnormal inflammation leads to maternal coagulopathies associated with placental haemostatic alterations in a rat model of foetal loss.Thromb Haemost. 2012 Mar 1;107(3):438-47.
-Othman M. Platelet-type von Willebrand disease: a rare, often misdiagnosed and underdiagnosed bleeding disorder.Semin
Thromb Hemost. 2011 Jul;37(5):464-9.
-Gupalo E, Buriachkovskaia L, Othman M. Human platelets express CAR with localization at the sites of intercellular interaction. Virol
J. 2011 Sep 30;8:456.
-Othman M, Lopez JA, Ware J.Platelet-type von Willebrand disease update: the disease, the molecule and the animal model. Expert
Rev Hematol. 2011 Oct;4(5):475-7.
-Renaud SJ, Cotechini T, Quirt JS, Macdonald-Goodfellow SK, Othman M, Graham CH Spontaneous pregnancy loss mediated
by abnormal maternal inflammation in rats is linked to deficient uteroplacental perfusion. J Immunol. 2011 Feb 1;186(3):1799-808.
-Chitlur M, Sorensen B, Rivard GE, Young G, Ingerslev J, Othman M, Nugent D, Kenet G, Escobar M, Lusher J. Standardization of Thromboelastography: A Report from the TEG-ROTEM Working Group. Haemophilia 2011 17(3):532-537
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