Cahill, Catherine M - Queen's University - Department of Biomedical and Molecular Sciences

个人简介

Neuropathic pain, a chronic debilitating condition affecting more than 3 million people in North America, imposes a significant burden on society by diminishing the individual's quality of life, and producing an enormous impact on healthcare costs, predicted to be over $100 million annually. Medical therapy for neuropathic pain continues to be a challenge for physicians as this pain is typically refractory to conventional treatments including opioid analgesics. Hence, a sustained research effort is required for elucidating the mechanisms underlying neuropathic pain in an attempt to address this largely unmet medical need. The focus of research in my laboratory is to explore the underlying mechanisms of chronic pain using behavioural, neuroanatomical and biochemical techniques.

研究领域

Neuropathic pain, a chronic debilitating condition affecting more than 3 million people in North America, imposes a significant burden on society by diminishing the individual's quality of life, and producing an enormous impact on healthcare costs, predicted to be over $100 million annually. Medical therapy for neuropathic pain continues to be a challenge for physicians as this pain is typically refractory to conventional treatments including opioid analgesics. Hence, a sustained research effort is required for elucidating the mechanisms underlying neuropathic pain in an attempt to address this largely unmet medical need. The focus of research in my laboratory is to explore the underlying mechanisms of chronic pain using behavioural, neuroanatomical and biochemical techniques.

近期论文

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Milne B., Sutak M., Cahill C.M. and Jhamandas K. (2008) Low doses of alpha(2)-adrenoceptor antagonists augment spinal morphine analgesia and inhibit development of acute and chronic tolerance. British Journal of Pharmacology. [Epub ahead of print, 2008 Sep 22]. Stroman P.W., Figley C.R. and Cahill C.M. (2008) Spatial normalization, bulk motion correction and coregistration for functional magnetic resonance imaging of the human cervical spinal cord and brainstem. Magnetic Resonance Imaging 26:809-814. Morano T.J., Bailey N.J., Cahill C.M. and Dumont E.C. (2008) Nuclei- and condition-specific responses to pain in the bed nucleus of the stria terminalis. Progress in Neuro-Psychopharmacology & Biological Psychiatry 32:643-650. Holdridge S.V., Armstrong S.A., Taylor A.M.W. and Cahill C.M. (2007) Behavioural and morphological evidence for the involvement of glial cell activation in delta opioid receptor function: implications for the development of opioid tolerance. Molecular Pain 3:7 (12 March 2007). Landau A.M., Yashpal K., Cahill C.M., St Louis M., Ribeiro-da-Silva A. and Henry J.L. (2007) Sensory neuron and substance P involvement in symptoms of a zymosan-induced rat model of acute bowel inflammation. Neuroscience 145:699-707. Holdridge S.V. and Cahill C.M. (2007) Spinal administration of a d opioid receptor agonist attenuates hyperalgesia and allodynia in a rat model of neuropathic pain. European Journal of Pain 11:685-693. Cahill C.M., Holdridge S.V. and Morinville A. (2007) Trafficking of d-opioid receptors and other G-protein-coupled receptors: implications for pain and analgesia. Trends in Pharmacological Sciences 28:23-31. Kabli N. and Cahill C.M. (2007) Anti-allodynic effects of peripheral delta opioid receptors in neuropathic pain. Pain 127:84-93. Gilron I., Watson P.N., Cahill C.M. and Moulin D.E. (2006) Neuropathic pain: a practical guide for the clinician. Canadian Medical Association Journal 175:265-275. Odrcich M., Bailey J.M., Cahill C.M. and Gilron I. (2006) Chronobiological characteristics of painful diabetic neuropathy and postherpetic neuralgia: diurnal pain variation and effects of analgesic therapy. Pain 120:207-212. Sharif Naeini R., Cahill C.M., Ribeiro-da-Silva A., Ménard H.A. and Henry J.L. (2005) Remodelling of spinal nociceptive mechanisms in an animal model of monoarthritis. European Journal of Neuroscience 22:2005-2015. Morinville A., Cahill C.M., Aibak H., Rymar V.V., Pradhan A., Hoffert C., Mennicken F., Stroh T., Sadikot A.F., O'Donnell D., Clarke P.B.S., Collier B., Henry J.L., Vincent J.P. and Beaudet A. (2004) Morphine-induced changes in d opioid receptor trafficking are linked to somatosensory processing in the rat spinal cord. Journal of Neuroscience 24:5549-5559. Morinville A., Cahill C.M., Kieffer B., Collier B. and Beaudet A. (2004) Mu-opioid receptor knockout prevents changes in delta-opioid receptor trafficking induced by chronic inflammatory pain. Pain 109:266-273. Morinville A., Cahill C.M., Esdaile M.J., Aibak H., Collier B., Kieffer B.L. and Beaudet A. (2003) Regulation of d-opioid receptor trafficking via µ-opioid receptor stimulation: evidence from µ-opioid receptor knock-out mice. Journal of Neuroscience 23:4888-4898. Cahill C.M., Morinville A., Hoffert C., O'Donnell D. and Beaudet A. (2003) Up-regulation and trafficking of d opioid receptor in a model of chronic inflammation: implications for pain control. Pain 101:199-208.