Reynolds, James N - Queen's University - Department of Biomedical and Molecular Sciences

个人简介

Fetal Brain Injury after Prenatal Alcohol Exposure. Dr. Reynolds research program at Queen's University has grown to encompass both basic and clinical investigations. His research interests over the past 25 years have centred around studies on the effects of alcohol on brain function. In particular, Dr. Reynolds' current research program is focused on understanding the neurobehavioural and cognitive deficits that are induced by prenatal exposure to alcohol. One of the key objectives is to investigate new approaches for assessing brain function in children with the goal of developing functional biomarkers of prenatal alcohol exposure. Novel intervention strategies to mitigate the effects of prenatal alcohol exposure in children is another area of interest for the research program. Dr. Reynolds has been funded for interdisciplinary basic and clinical investigations into the cellular mechanisms and neurobehavioural consequences of Fetal Alcohol Spectrum Disorder (FASD), and is one of the project leaders in NeuroDevNet, a national Network of Centres of Excellence in developmental neuroscience. In this role, Dr. Reynolds co-ordinates multi-centre, cross-Canada projects encompassing basic science and clinical studies in FASD that involve genetics, brain imaging, neurobehavioural assessments and intervention studies.

研究领域

Fetal Alcohol Spectrum Disorders Cognitive and Behavioural Deficits in Children with FASD Eye movement control is a powerful tool for assessing various aspects of brain function, including sensory-motor control and cognitive flexibility. Our studies have demonstrated that behavioural deficits in eye movement control can be measured in children with FASD. Future studies will be aimed at developing eye movement tasks and other novel tools that can be used to assess brain function in children with FASD and other neurodevelopmental disorders.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Paolozza, A., R. Munn, D.P. Munoz, J.N. Reynolds. Eye movements reveal sexually dimorphic deficits in children with fetal alcohol spectrum disorder. Front. Neurosci. 2015, 9:76. doi: 10.3389/fnins.2015.00076 Bell, E., G. Andrew, N. Di Pietro, A.E. Chudley, J.N. Reynolds, E. Racine. It’s a shame! Stigma against fetal alcohol spectrum disorder: Examining the ethical implications for public health practices and policies, Pub. Health Ethics (in press). Paolozza, A., S. Treit, C. Beaulieu, J.N. Reynolds. Response Inhibition Deficits in Children with Fetal Alcohol Spectrum Disorder: Relationship between Diffusion Tensor Imaging of the Corpus Callosum and Eye Movement Control. Neuroimage Clin. 2014, Jun 4;5:53-61. doi: 10.1016/j.nicl.2014.05.019. eCollection 2014. Paolozza, A., C. Rasmussen, J. Pei, A. Hanlon-Dearman, S.M. Nikkel, G. Andrew, A. McFarlane, D. Samdup, J.N. Reynolds, Working memory and visuospatial deficits correlate with oculomotor control in children with Fetal Alcohol Spectrum Disorder, Behav. Brain Res. 263 (2014) 70-79. Paolozza, A., C. Rasmussen, J. Pei, A. Hanlon-Dearman, S.M. Nikkel, G. Andrew, A. McFarlane, D. Samdup, J.N. Reynolds, Deficits in response inhibition correlate with oculomotor control in children with Fetal Alcohol Spectrum Disorder and Prenatal Alcohol Exposure, Behav. Brain Res. 259 (2014) 97-105. Williams, L., C.P.T. Jackson, N. Choe, L. Pelland, S.H. Scott, and J.N. Reynolds, Sensory-motor deficits in children with fetal alcohol spectrum disorder assessed using a robotic virtual reality platform, Alcohol. Clin. Exp. Res. 38 (2014) 116-125. Zizzo, N., N. DiPietro, C. Green, J. Reynolds, E. Bell, and E. Racine, Comments and reflections on ethics in screening for biomarkers of prenatal alcohol exposure, Alcohol. Clin. Exp. Res. 37 (2013) 1451-1455. Paolozza, A., R. Titman, D. Brien, D.P. Munoz, and J.N. Reynolds, Altered Accuracy of Saccadic Eye Movements in Children with Fetal Alcohol Spectrum Disorder, Alcohol. Clin. Exp. Res. 37 (2013) 1491-1498. Tseng, P.-H., I.G.M. Cameron, G. Pari, J.N. Reynolds, D.P. Munoz, and L. Itti. High-throughput classification of clinical populations from natural viewing eye movements, J. Neurol. 260 (2013) 275-284. Green, C.R., A.M. Mihic, D.C. Brien, I.T. Armstrong, S.M. Nikkel, B.C. Stade, C. Rasmussen, D.P. Munoz and J.N. Reynolds. Oculomotor deficits in children with fetal alcohol spectrum disorders assessed using a mobile laboratory. Eur. J. Neurosci. 29 (2009) 1302-1309. Green, C.R., A.M. Mihic, S.M. Nikkel, B.C. Stade, C. Rasmussen, D.P. Munoz and J.N. Reynolds. Executive function deficits in children with fetal alcohol spectrum disorders (FASD) measured using the Cambridge Neuropsychological Tests Automated Battery (CANTAB), J. Child Psychol. Psychiatry 50 (2009) 688-697.