Pang, Stephen C - Queen's University - Department of Biomedical and Molecular Sciences

个人简介

The research program of Dr. Stephen Pang is on the structure and function of the cardiovascular system in health and disease. His current research focus is on the design of gene therapies for the treatment of myocardial infarction (MI or heart attack). Using atrial natriuretic peptide (ANP) as a cardioprotective molecule, Dr. PangÕs laboratory is designing a new gene construct in order to protect the heart immediately following MI. Collaborations with Drs. Amer Johri (Cardiology), Albert Jin (Neurology), and David Andrew, Dr. PangÕs laboratory is studying the link between abnormal atrial natriuretic peptide expression, heart attack and stroke. Drs. Stephen Waldman (Mechanical Engineering), Davide Bardana (Orthopedic Surgery), James Stewart and Manuela Kunz (Computing), Mark Hurtig (Ontario Veterinary College, Univ. of Guelph), Andrew Winterborn (Health Sciences) and Pang are current working on methods of producing engineered articular cartilage for implantation and joint repair. With the collaborations of Drs. Will King, Janet Ashbury (Epidemiology), Stephen Vanner (GIDRU) and Sherry Taylor (Pathology, Dalhousie Univ.), Yat Tse, the Pang lab has established a method of quantifying LINE-1 DNA methylation and applying it in an epidemiological study to screen colorectal cancer.

研究领域

The research program of Dr. Stephen Pang is on the structure and function of the cardiovascular system in health and disease. His current research focus is on the design of gene therapies for the treatment of myocardial infarction (MI or heart attack). Using atrial natriuretic peptide (ANP) as a cardioprotective molecule, Dr. Pang’s laboratory is designing a new gene construct in order to protect the heart immediately following MI. With the collaboration of Drs. Yat Tse, Luis Melo and Christopher Ward (Physiology), Dr. Pang is evaluating methods for developing a stem cell-based therapy for MI. Drs. Brian Amsden (Chemical Engineering) and Pang are developing a method of delivering hepatic growth factor as a means to treat MI. Drs. Stephen Waldman (Mechanical Engineering) and Pang are current working on methods of producing engineered articular cartilage for implantation and joint repair.

近期论文

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1. Sangaralingham, SJ; MY Tse, SC Pang. Estrogen protects against the development of salt-sensitive cardiac hypertrophy in heterozygous proANP gene disrupted mice. Journal of Endocrinology; Accepted April 16, 2007. (In press) 2. O’Tierney, PF, MY Tse, SC Pang. Elevated renal norepinephrine in proANP gene-disrupted mice is associated with increased tyrosine hydroxylase expression in sympathetic ganglia. Regulatory Peptides; Accepted Epub: April 11, 2007. (In Press) 3. Liu, X.-L., JA Simpson, KR Brunt, CA Ward, SRR Hall, RT Kinobe, V Barrette, MY Tse, SC Pang, AS Pachori, VJ Dzau, KO Ogunyankin, LG Melo. Pre-emptive heme oxygenase-1 gene delivery reveals reduced mortality and preservation of left ventricular function one-year after acute myocardial infarction. American Journal of Physiology Heart and Circulatory Physiology, Accepted Epub: Feb 23 2007. (In Press) 4. Bell, EN; MY Tse; LJ Frederikson; A Gardhouse; SC Pang; CH Graham; DR Siemens. Atrial natriuretic peptide attenuates hypoxia induced chemoresistance in prostate cancer cells. Journal of Urology 177(2): 751-756, 2007. 5. Amsden, BG; MY Tse; ND Turner; DK Knight; SC Pang. In vivo degradation behavior of photo-cross-linked star-poly(epsilon-caprolactone-co-D,L-lactide) elastomers. Biomacromolecules 7(1): 365-372, 2006. Brunt, KR, KK Fenrich, G Kiani, MY Tse, SC Pang, CA Ward, LG Melo. Protection of human vascular smooth muscle cells from H2O2-induced apoptosis through functional codependence between HO-1 and AKT. Arteriosclerosis, Thrombosis and Vascular Biology 26(9):2027-2034, 2006.