个人简介

BS University of Virginia, Charlottesville, VA, 1997 PhD University of Virginia, Charlottesville, VA, 2002 NIH Postdoctoral Fellow, Harvard University, Cambridge, MA, 2002-2006 Assistant Professor of Chemistry, Virginia Tech, 2006 Associate Professor of Chemistry, Virginia Tech, 2013

研究领域

Bioorganic and Medicinal Chemistry

We are interested in using chemistry to understand biological processes. Central to our theme is organic chemistry as a tool that intersects with molecular life sciences such as molecular and cell biology. Our primary focus is the development of chemical toolboxes to address problems in biology. Currently, our work is aimed at the following: Development of novel diboron reagents for the mild and selective boration of activated carbon-carbon bonds Development of medium-sized branched peptides to target RNA structures associated with HIV as the next generation anti-HIV therapeutics Defining the roles of sphingosine kinases in hyperproliferative diseases by developing cell permeable small molecule libraries as probes Development of N-terminal peptidic boronic acids as protease inhibitors

近期论文

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Zhang, W.; Bryson, D.I.; Crumpton, J.B.; Wynn, J. and Santos, W. L. Branched Peptide Boronic Acids (BPBAs): A Novel Mode of Binding Towards RNA. Chem. Commun. 2013, 49, 2436-2438. DOI: 10.1039/C3CC00243H. Bryson, D.R.; Zhang, W.; McLendon, P.M.; Reineke, T.M. and Santos, W.L. Toward Targeting RNA Structure: Branched Peptides as Cell-Permeable Ligands to TAR RNA. ACS Chem. Biol. 2012, 7, 210–217. DOI: 10.1021/cb200181v. Kharel, Y.; Raje, M.; Gao, M.; Gellett, A.M.; Tomsig, J.L.; Lynch, K.R. and Santos, W.L. Sphingosine kinase type 2 inhibition elevates circulating sphingosine-1-phosphate. Biochem. J. 2012, 447, 149-157.doi:10.1042/BJ20120609 Raje, M.R.; Knott, K.; Kharel, Y.; Bissel, P.; Lynch, K.R. and Santos, W.L. Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors. Bioorg. Med. Chem. 2012, 20, 183-194.DOI:10.1016/j.bmc.2011.11.011. Calderone, J.A. and Santos, W.L. Copper(II)-Catalyzed Silyl Conjugate Addition to α,β-Unsaturated Conjugated Compounds: Brønsted Base-Assisted Activation of Si–B Bond in Water. Org. Lett. 2012, 14, 2090-2093. DOI: 10.1021/ol300618j Thorpe, S.B.; Calderone, J.A. and Santos, W.L. Unexpected copper (II) catalysis: Catalytic amine base promoted β-borylation of α,β-unsaturated carbonyl compounds in water. Org. Lett. 2012, 14, 1918-1921. DOI:10.1021/ol300575d.