Lomax, Alan E G - Queen's University - Department of Biomedical and Molecular Sciences

个人简介

My laboratory studies how interactions between the microbiota, nervous system and the immune system can contribute to symptom generation in inflammatory bowel disease. We also investigate the regulation of neurogenesis in the enteric nervous system.

研究领域

We study enteric neurons and nociceptive neurons to understand how neuroplasticity can lead to pain and altered function during disease. Our research on neurogenesis focusses on factors that suppress the generation of new neurons in the adult enteric nervous system. Extensive collaborations with clinicians at Kingston General Hospital enables translational work using patient biopsies and microbiota.

近期论文

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Lukewich MK, Lomax AE (2015). Mouse models of sepsis elicit spontaneous action potential discharge and enhance intracellular Ca2+ signalling in sympathetic postganglionic neurons. Neuroscience 284: 668-677. Moynes DM, Vanner S, Lomax AE (2014). Participation of interleukin 17A in neuroimmune interactions. Brain, Behaviour and Immunity 41: 1-9. Provided issue’s cover image. Benson JR, Xu J, Moynes DM, Lapointe TL, Altier C, Vanner S, Lomax AE (2014). Sustained neurochemical plasticity in the central terminals of mouse DRG neurons following colitis. Cell and Tissue Research 356: 309-317. Lukewich MK, Lomax AE (2014). Endotoxemia enhances catecholamine secretion from male mouse adrenal chromaffin cells through an increase in Ca2+-induced Ca2+ release from the endoplasmic reticulum. Endocrinology 155: 180-192. Lukewich MK, Rogers RC, Lomax AE (2014). Divergent neuroendocrine responses to localised and systemic inflammation. Seminars in Immunology 26: 402-408. Lukewich MK, Lomax AE (2013). Toll-like receptor 4 activation reduces adrenal chromaffin cell excitability through a nuclear factor kB-dependent pathway. Endocrinology 154: 351-362. Roberts JA, Lukewich MK, Sharkey KA, Furness JB, Mawe GM, Lomax AE (2012). The roles of purinergic signalling during gastrointestinal inflammation. Current Opinion in Pharmacology 12: 659-666. Hao MM, Lomax AE, McKeown SJ, Reid CA, Young HM, Bornstein JC (2012). Early development of electrical excitability in the mouse enteric nervous system. Journal of Neuroscience 32: 10949-10960. Featured in This Week in the Journal. Chisholm SP, Cervi A, Nagpal S, Lomax AE (2012). Interleukin 17A increases neurite outgrowth from adult postganglionic sympathetic neurons. Journal of Neuroscience 32: 1146-1155. Provided issue’s cover image. Lukewich MK, Lomax AE (2011). Altered adrenal chromaffin cell function during experimental colitis. American Journal of Physiology, Gastrointestinal and Liver Physiology 300: G654-664. Bertrand PP, Barajas-Espinosa AR, Bertrand RL, Lomax AE (2010). Real time electrochemical detection of mucosal serotonin release during experimental colitis. American Journal of Physiology, Gastrointestinal and Liver Physiology 298: G446-G455. Motagally M, Lukewich MK, Chisholm SP, Neshat S, Lomax AE (2009). Tumor necrosis factor α activates nuclear factor kB to inhibit N-type voltage-gated Ca2+ current in postganglionic sympathetic neurons. Journal of Physiology 587: 2623-2634. Lomax AE, O’Reilly MT, Neshat S and Vanner S (2007). Sympathetic vasoconstrictor regulation of mouse colonic submucosal arterioles is altered in experimental colitis. Journal of Physiology 583: 719-730.