Craig, Andrew - Queen's University - Department of Biomedical and Molecular Sciences

个人简介

My lab studies tyrosine kinase signaling pathways that regulate cell motility, tissue invasion and inflammation. We currently have projects focusing on mast cells, that produce a wide array of mediators that can remodel tissues during immune responses and regulate tumour progression. We also study contributions of F-BAR proteins in metastatic cancers using cell and mouse models.

研究领域

Cancer metastasis pathways My research program is investigating paracrine signaling pathways linked to mast cell activation, systemic mastocytosis and cancer metastasis. Of particular interest are discovering the molecular mechanisms controlling cell motility and invasion in mast cells and cancer cells. We employ RNA interference, cell biology, transgenic mouse models, and tumor xenografting in the course of these studies. We have research ongoing to study functions of kinases and adaptor proteins targeted to membranes via their F-BAR domains in mast cells and cancer cell models. These projects will help define how F-BAR proteins contribute to the dynamic control of membranes via regulating actin assembly and other pathways. Biosketch: My training commenced at Queen's University (B.Sc.Honours Biochemisty, 1993, with distinction), and continued as a graduate student in Dr. Sonenberg’s lab at McGill University where I studied regulation of mRNA translation (Ph.D, 1998, McLaughlin Thesis award). I returned to Queen’s University for a post-doctoral fellowship with Dr. Peter Greer in the Cancer Research Labs ('98-02; CIHR PDF and Senior Research Fellowship), where I helped develop and characterize transgenic mice lacking Fer protein-tyrosine kinase activity. Studies of Fer-deficient mice have provided new insights into the role of Fer kinase in inflammation, growth factor signaling in fibroblasts, and regulation of mast cell activation and migration. I was appointed to a faculty position in Biochemistry at Queen’s in July 2002 (CIHR New Investigator award) and have mentored 13 former trainees(4 PDF, 3 PhD, 6 MSc). The lab currently consists of 1 PDF, 3 PhD students, 2 MSc students, and a research technician.

近期论文

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Tomas Baldassarre, P Truesdell, K Watt, J Meens, MM Schneider, SK Sengupta, and AWB Craig (2015) Endophilin A2 Promotes Triple Negative Breast Cancer Progression and Metastasis, Mol Cancer Res, Mar 17 Epub. Otto L.D. Cerqueira, Peter Truesdell, Tomas Baldassarre, Santiago A. Vilella-Arias, Kathleen Watt, Jalna Meens, Harish Chander, Cynthia A.B. Osório, Fernando A. Soares, Eduardo M. Reis* and Andrew W.B. Craig* (2015) CIP4 promotes metastasis in triple-negative breast cancer and is associated with poor patient prognosis, Oncotarget, 6:9397-408. Namit Sharma and Andrew W Craig (2015) Leukocyte-targeting toxins as therapeutics in allergic asthma, J Leuk Biol, 97:345-6. Harish Chander, Colin D. Brien, Peter Truesdell, Kathleen Watt, Jalna Meens, Colleen Schick, Doris Germain and Andrew W.B. Craig (2014) Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis, Breast Cancer Research, 16:3413. P Truesdell, J Ahn, H Chander, J Meens, K Watt, X Yang, and AWB Craig (2014) CIP4 Promotes Lung Adenocarcinoma Metastasis and Is Associated with Poor Prognosis, Oncogene, Sept 1 Epub. Namit Sharma, Stephanie Everingham, Lifan Zeng, Zhong-Yin Zhang, Reuben Kapur, and Andrew W.B. Craig (2014) Oncogenic KIT-induced aggressive systemic mastocytosis requires SHP2/PTPN11 phosphatase for disease progression in mice Oncotarget, 5(15):6130-41; featured on the cover Aug 30 issue. Namit Sharma, Stephanie Everingham, Baskar Ramdas, Reuben Kapur, and Andrew WB Craig (2014) SHP2 phosphatase promotes mast cell chemotaxis towards SCF via enhancing activation of the Lyn/Vav/Rac signaling axis, J Immunol. 192(10):4859-66. Vijay Kumar, Stephanie Everingham, Christine Hall, Peter A. Greer and Andrew W.B. Craig (2014) Calpains promote neutrophil recruitment and bacterial clearance in an acute bacterial peritonitis model, Eur J Immunol., 44:831-841; featured article “In This Issue”; cited by 2 papers. Joseph Ahn, Peter Truesdell, Jalna Meens, Carli Kadish, Xiaolong Yang, Alexander H. Boag and Andrew W.B. Craig (2013) Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis, Mol Cancer Res, 11:952-63. cited by 7 papers. Maitham Khajah, Graciela Andonegui, Ronald Chan, Andrew W. Craig, Peter A. Greer & Donna-Marie McCafferty (2013) Fer Kinase Limits Neutrophil Chemotaxis towards End Target Chemoattractants, J Immunol, 190:2208-16; cited by 6 papers. Harish Chander, Peter Truesdell, Jalna Meens and Andrew W.B. Craig (2013) Transducer of Cdc42-dependent Actin Assembly Promotes Breast Cancer Invasion and Metastasis, Oncogene 32:3080-90; featured article; cited by 3 papers. Andrew W.B. Craig (2012) The family infighting continues: dualling Src family kinases now linked to activating IgG receptor signalling and anaphylaxis, Frontiers in Inflammation, 3:137 Raghuveer Singh Mali, Peilin Ma, Li-Fan Zeng, Holly Martin, Baskar Ramdas, Yantao He, Emily Sims, Sarah Nabinger, Joydeep Gosh, Namit Sharma, Veerendra Munugalavadla, Anindya Chatterjee, Shuo Li, George Sandusky, Andrew W. Craig, Kevin D. Bunting, Gen-Sheng Feng, Rebecca J. Chan, Zhong-Yin Zhang and Reuben Kapur (2012) Role of SHP2 phosphatase in KIT induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT, Blood.120:2669-78; cited by 21 papers. Namit Sharma, Vijay Kumar, Stephanie Everingham, Raghuveer Singh Mali, Reuben Kapur, Li-Fan Zeng, Zhong-Yin Zhang, Gen‐Sheng Feng, Karin Hartmann, Axel Roers, and Andrew W.B. Craig (2012) SH2 domain‐containing phosphatase‐2 is a critical regulator of mast cell survival and homeostasis in mice, Mol. Cell. Biol., 32:2653-2663; featured on the cover of June 2013 issue; cited by 10 papers. Ester Kwok, Shengnan Zhang, Peter A. Greer, John S. Allingham and Andrew W.B. Craig (2012) FES Kinase Promotes Mast Cell Recruitment to Mammary Tumors Via the Stem Cell Factor/KIT Receptor Signaling Axis, Molecular Cancer Research, 10:881-891; cited by 6 papers; featured on the cover and highlights section of July issue Andrew W.B. Craig (2012) FES/FER kinase signaling in hematopoetic cells and leukemias. Frontiers in Bioscience, 17:861-875; cited by 9 papers. Peilin Ma, Raghuveer Singh Mali, Veerendra Munugalavadla, Subha Krishnan, Baskar Ramdas, Emily Sims , Holly Martin, Joydeep Ghosh, Shou Li, Rebecca Chan, Gerald Krystal, Andrew W. Craig, Clifford Takemoto and Reuben Kapur (2011) The PI3K drives the maturation of mast cells via microphthalmia transcription factor, Blood, 118:3459-69; cited by 10 papers. Jinghui Hu, Alka Mukhopadhyay, Peter Truesdell, UK Mukhopahyay, Alan Mak and Andrew WB Craig (2011) Cdc42-Interacting Protein 4 is a Src substrate that regulates invadopodia and breast tumor invasiveness via promoting MT1-MMP endocytosis, J. Cell Sci., 124: 1739-1751; featured on the cover of the May issue; cited by 24 papers; reviewed in F1000: Buccione R: "Transmembrane type I matrix metalloprotease…” Jinghui Hu, Alka Mukhopadhyay and Andrew WB Craig (2011) Transducer Of Cdc42-dependent actin assembly promotes epidermal growth factor-induced cell motility and invasiveness, J. Biol. Chem., 286:2261-72; cited by 19 papers Julie Smith, Lionel Samayawardhena and Andrew Craig (2010) Fps/Fes protein-tyrosine kinase regulates mast cell adhesion and migration downstream of Kit and b1 integrin receptors, Cell. Signal, 22:427-436; cited by 13 papers. Victor A. McPherson, Namit Sharma, Stephanie Everingham, Julie Smith, Helen H. Zhu, Gen-Sheng Feng and Andrew W.B. Craig (2009) SHP2 Protein-Tyrosine Phosphatase Promotes FcεRI-induced Activation of Fyn and Erk Pathways Leading to TNFα Release from Bone Marrow-derived Mast Cells, J. Immunol., 183:4940-4947; cited by 12 papers. Jinghui Hu, Flavia Troglio , Alka Mukhopadhyay, Stephanie Everingham, Ester Kwok, Giorgio Scita, and Andrew W.B. Craig (2009) F-BAR-containing adaptor CIP4 localizes to early endosomes and regulates Epidermal Growth Factor Receptor trafficking and downregulation, Cell. Signal, 21, 1686-1697; cited by 26 papers. Victor McPherson, Stephanie Everingham, Robert Karisch, Julie Smith, Chris Udell, Jimin Zheng, Zongchao Jia, and Andrew W.B. Craig (2009) Contributions of F-BAR and SH2 Domains of FES Protein-Tyrosine Kinase For Coupling to the FceRI Pathway in Mast Cells, Mol. Cell. Biol. 29:389-401; cited by 18 papers. Lei Liu, Andrew W. Craig, Heather D. Meldrum, Bruce E. Elliott, and Marlys L. Koschinsky (2008) Integrin aVb3 is Required for Apolipoprotein(a) Stimulation of Vascular Endothelial Cell Growth and Migration, Biochem. J., 418:325-36; cited by 7 papers.