Adams, Michael A - Queen's University - Department of Biomedical and Molecular Sciences

个人简介

B.ScH Physiology & Pharmacology, University of Western Ontario (1979), Ph.D. Pharmacology and Toxicology, University of Western Ontario (1985), Post-Doctoral Fellowship, Baker Medical Research Institute, Melbourne, Australia; Supervisors: Alex Bobik and Paul I. Korner (1985-1988) Dr. Michael Adams and Dr. Rachel Holden (Division of Nephrology, Department of Medicine) run a collaborative research laboratory. The long term goal of their research is to contribute to a greater understanding of the causes and consequences of cardiovascular and kidney disease and to apply this knowledge to the development and implementation of new therapeutic strategies for prevention and treatment. A specific area of current research, in collaboration with Dr. Glenville Jones, seeks to optimize treatment strategies, involving combination vitamin K and vitamin D therapies, to manage vascular calcification resulting from chronic kidney disease (CKD).

研究领域

Dr. Michael Adams and Dr. Rachel Holden (Division of Nephrology, Department of Medicine) run a collaborative research laboratory. The long term goal of our research is to contribute to a greater understanding of the causes and consequences of cardiovascular and kidney disease, as well as sexual dysfunction, and to apply this knowledge to the development and implementation of new therapeutic strategies for prevention and treatment. Exploring the etiologies of circulatory abnormalities has followed varied approaches for many years including roles for changes in neural, hormonal and local factors as well as in vascular structure. Within that framework our investigations focus on the critical and fundamental role that vascular remodeling plays in producing changes to circulatory health. Specifically, in conditions such as CKD, we are targeting the mechanistic underpinnings of abnormal circulatory states such as endothelial dysfunction, increased pulse pressure, elevated pulse wave velocity, and hypertension. We are also interested in determine the potential efficacy of various treatments to prevent or reverse the pathological vascular structural changes. In particular, our overall working hypothesis has been that pharmacotherapy-induced regression or prevention of pathogenic changes in cardiovascular structure imparts a more permanent normalization of the circulatory function; i.e. providing a 'cure' rather than just relief of signs and symptoms. In this regard, a current research focus, in collaboration with Dr. Glenville Jones, seeks to optimize treatments involving combination vitamin K and vitamin D delivery to manage the onset and development of vascular calcification resulting from chronic kidney disease (CKD).

近期论文

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Smallegange C, Kline RL, Adams MA. Transplantation of enalapril-treated kidneys confers persistent lowering of arterial pressure in SHR. Hypertension 42:932-936, 2003 Smallegange C, Hale TM, Bushfield TL, Adams MA. Persistent Lowering of Pressure by Transplanting Kidneys from Adult Spontaneously Hypertensive Rats Treated with Brief Antihypertensive Therapy. Hypertension 44: 89-94, 2004 Hannan JL, Smallegange C, Hale TM, Heaton JPW, Adams MA. Impact of Antihypertensive Treatments on Erectile Responses in Aging Spontaneously Hypertensive Rats. J Hypertension. 24: 159-168, 2006 Hannan JL., Heaton JPW, Adams MA. Recovery of Erectile Function in Aging Hypertensive and Normotensive Rats Using Exercise and Caloric Restriction, Journal of Sexual Medicine 4: 886–897, 2007 Bourque SL, Komolova M, Nakatsu K, Adams MA. Long-Term Circulatory Consequences of Perinatal Iron-Deficiency in Male Wistar Rats. Hypertension 51:154-159, 2008. Burke SD, Barrette VF, Bianco J, Thorne JG, Yamada AT, Pang SC, Adams MA and Croy BA. Spiral Arterial Remodeling is Not Essential for Normal Blood Pressure Regulation in Pregnant Mice. Hypertension 55:729-737, 2010 Komolova M and Adams MA. Moment-to-Moment Characteristics of the Relationship Between Arterial Pressure and Renal Interstitial Hydrostatic Pressure, Hypertension, 56; 650-657, 2010 Hannan JL, Blaser MC, Oldfield L, Pang, SC, Pang JJ, Adams SM and Adams MA Morphological and Functional Evidence for the Contribution of the Pudendal Artery in Aging-Induced Erectile Dysfunction. J. Sex. Med. 7(10):3373–3384, 2010 Taben M. Hale, Terri L. Bushfield, Jeanette Woolard, Judy J. Pang, Karen J. Rees-Milton, Michael A. Adams. Changes Critical to Persistent Lowering of Arterial Pressure in Spontaneously Hypertensive Rat Occur Early in Antihypertensive Treatment. Journal of Hypertension 29(1): 113–122, 2011 JL Hannan, Blaser MC, Pang JJ, Adams SM, Pang SC, Adams MA. Impact of Hypertension, Aging and Antihypertensive Treatment on the Morphology of the Pudendal Artery. Journal of Sexual Medicine 8:1027–1038, 2011 SL Bourque, Davidge ST, Adams MA. The interaction between endothelin-1 and nitric oxide in the vasculature: new perspectives. Am. J. Physiol. Regul. Integr. Comp. Physiol. 300: R1288–R1295, 2011. Croy BA, Burke SD, Barrette VF, Zhang J, Hatta K, Smith GN, Bianco J, Yamada AT, Adams MA. Identification of the primary outcomes that result from deficient spiral arterial modification in pregnant mice. Pregnancy Hypertension: An International Journal of Women’s Cardiovascular Health. 1;1(1):87-94. 2011 MacKenzie L, Heaton JPW and Adams MA. Impact of Systemically Active Neurohumoral Factors on the Erectile Response of the Rat. J. Sexual Medicine 8:2461–2471, 2011 SD Burke,VF Barrette, S David, EV Khankin, MA Adams and BA Croy. Circulatory and Renal Consequences of Pregnancy in Diabetic NOD Mice. Placenta 32; 949-955, 2011 Hannan JL, Cheung GL, Blaser MC, Pang JJ, Pang SC, Webb RC, Adams MA. Characterization of the vasculature supplying the genital tissues in female rats. J Sex Med. 9(1):136-147, 2012 Bourque SL, Komolova M, McCabe K, Adams MA, Nakatsu K. Perinatal iron deficiency combined with a high-fat diet causes obesity and cardiovascular dysregulation. Endocrinology. 153(3):1174-82. 2012 Bourque SL, Whittingham HA, Brien SE, Davidge ST, Adams MA. Role of endothelin-1 in the hyper-responsiveness to nitrovasodilators following acute NOS inhibition. Br J Pharmacol. 165(6):1992-1999, 2012. Komolova M, Friberg P and Adams MA. Altered Vascular Resistance Properties and Acute Pressure-Natriuresis Mechanism in Neonatal and Weaning Spontaneously Hypertensive Rats. Hypertension 59(5):979-84, 2012 Maio TM, Hannan JL, Komolova M and Adams MA. Caloric Restriction Prevents Visceral Adipose Tissue Accumulation and Maintains Erectile Function in Aging Rats. J. Sex. Med 9(9), 2273–2283, 2012 McCabe KM, Booth SL, Fu X, Shobeiri N, Pang JJ, Adams MA and Holden RM. Dietary Vitamin K and Therapeutic Warfarin Alter the Susceptibility to Vascular Calcification in Experimental Chronic Kidney Disease. Kidney International, 83(5):835-44 (2013) Shobeiri N, Pang JJ Adams MA, Holden RM. Cardiovascular Disease in an Adenine-Induced Model of Chronic Kidney Disease; The Temporal Link Between Vascular Calcification and Hemodynamic Consequences. J. Hypertension 31(1):160-168 (2013) Aasa KL, Kwong KK, Adams MA, Croy BA. Analysis of maternal and fetal cardiovascular systems during hyperglycemic pregnancy in the nonobese diabetic mouse. Biol. Reproduction. 88(6):151. (2013) McCabe KM, Adams MA, Holden RM, Vitamin K Status in Chronic Kidney Disease. Nutrients. 5(11): 4390–4398 (2013) Shobeiri N, Adams MA, Holden RM. Phosphate: an old bone molecule but new cardiovascular risk factor. Br J Clin Pharmacol. 77(1):39-54 (2014)