Matson, John B. - Virginia Polytechnic Institute and State University

个人简介

Professor of Chemistry Virginia Tech (Blacksburg, VA) 2021 – present Dr. AC Lilly Jr. Faculty Fellow of Nanoscience Virginia Tech (Blacksburg, VA) 2020 – present Associate Professor of Chemistry Virginia Tech (Blacksburg, VA) 2018 – 2021 Assistant Professor of Chemistry Virginia Tech (Blacksburg, VA) 2012 – 2018 Postdoctoral Fellow Northwestern University (Chicago, IL) Institute for BioNanotechnology in Medicine Advisor: Samuel I. Stupp 2009-2012 Ph.D. California Institute of Technology (Pasadena, CA) Department of Chemistry Advisor: Robert H. Grubbs Thesis Title: Applications and Extensions of Living Ring-Opening Metathesis Polymerization 2004-2009 A. B. Washington University in St. Louis (St. Louis, MO) Majors: Chemistry, German Advisor: Karen L. Wooley 2000-2004 SELECTED AWARDS AND HONORS 2022 – Alan F. Clifford Faculty Service Award (Virginia Tech Dept. of Chemistry) 2022 – Materials Today European Polymer Journal Award 2020 – Humboldt Research Fellowship for Experienced Researchers (Germany) 2019 – John C. Schug Research Award (Virginia Tech Dept. of Chemistry) 2019 – Thieme Chemistry Journal Award 2018 – Camille Dreyfus Teacher-Scholar Award 2018 – ACS PMSE Division Young Investigator Award 2017 – Virginia Tech nominee for SCHEV Rising Star Award (Commonwealth of Virginia) 2016 – Jimmy W. Viers Teaching Award (Virginia Tech Dept. of Chemistry) 2015-2020 – NSF CAREER Award 2015 – 3M Non-Tenured Faculty Award 2014 – Ralph E. Powe Junior Faculty Enhancement Award 2011-2012 – NIH National Research Service Award Postdoctoral Fellowship 2009-2011 – Baxter Early Career Development Fellowship Award in Bioengineering 2009 – ACS POLY Division Excellence in Graduate Polymer Research Award 2008 – NSF Travel Grant to NATO Advanced Study Institute

研究领域

Therapeutic H2S Delivery: Bottlebrush Polymers: New Renewable and Degradable Polymers: Self-Assembling Peptide-Based Materials:

近期论文

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Enzyme-triggered chemodynamic therapy via a peptide-H2S donor conjugate with complexed Fe2+Zhu, Y.; Archer, W. R.; Morales, K. F.; Schulz, M. D.; Wang, Y.; Matson, J. B. Angew. Chem. Int. Ed. 2023 DOI: 10.1002/anie.202302303 N-thiocarboxyanhydrides, amino acid-derived enzyme-activated H2S donors, enhance sperm mitochondrial activity in presence and absence of oxidative stress Pintus, E.; Chinn, A. F.; Kadlec, M.; García-Vázquez F. A.; Novy, P.; Matson, J. B.; Ros-Santaella, J. L.BMC Vet. Res. 2023, 19 DOI: 10.1186/s12917-023-03593-5 Terminology for chain polymerization (IUPAC Recommendations 2021)Fellows, C. M.; Jones, R. G.; Keddie, D. J.; Luscombe, C. K.; Matson, J. B.; Moad, G.; Matyjaszewski, K.; Merna, J.; Nakano, T.; Penczek, S.; Russell, G. T.; Topham, P. D. Pure. Appl. Chem. 2022, 94, 1093-1147 DOI: 10.1515/pac-2020-1211 A Brief Guide to Polymerization Terminology (IUPAC Technical Report) Luscombe, C.K.; Moad, G.; Hiorns, R.C.; Jones, R. G.; Keddie, D. J.; Matson, J. B.; Merna, J.; Nakano, T.; Russell, G. T.; Topham, P. D.Pure. Appl. Chem. 2022, 94, 1079-1084 DOI: 10.1515/pac-2021-0115 Radical–radical coupling effects in the direct-growth grafting-through synthesis of bottlebrush polymers using RAFT and ROMP Alaboalirat, A.; Vu, C.; Matson, J. B.Polym. Chem. 2022, 13, 5841-5851 DOI: 10.1039/D2PY00794K Fluorescent detection of hydrogen sulfide (H2S) through the formation of pyrene excimers enhances H2S quantification in biochemical systems Pose, M.; Dillon, K. M.; Denicola, A.; Alvarez, B.; Matson, J. B.; Möller, M. N.; Cuevasanta, E.J. Biol. Chem. 2022, 298, 102402 DOI: 10.1016/j.jbc.2022.102402 Book Chapter: “Macromolecular and Supramolecular Approaches for H2S Delivery” Hydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies. Swilley-Sanchez, S. N.; Li, Z.; Matson, J. B. John Wiley and Sons, New Jersey, 2022, 373-425 DOI: 10.1002/9781119799900.ch15 Electrospun scaffolds functionalized with a hydrogen sulfide donor stimulate angiogenesis Yao, T.; van Nunen, T.; Rivero, R.; Powell, C.; Carrazzone, R.; Kessels, L.; Wieringa, P. A.; Hafeez, S.; Wolfs, T.; Moroni, L.; Matson, J. B.; Baker, M. B. ACS Appl. Mater. Interfaces 2022, 14, 25, 28628–28638 DOI: 10.1021/acsami.2c06686 Complex polymer architectures using ring-opening metathesis polymerization: synthesis, applications, and practical considerations Blosch, S. E.; Scannelli, S. J.; Alaboalirat, M.; Matson, J. B.Macromolecules 2022, 55, 4200-4227 DOI: 10.1021/acs.macromol.2c00338 pH-Responsive self-assembling peptide-based biomaterials: designs and applications Li, Z.; Zhu, Y.; Matson, J. B. ACS Appl. Bio. Mater. 2022, 5, 4635-4651 DOI: 10.1021/acsabm.2c00188 Solvent effects in grafting-through ring-opening metathesis polymerization Blosch, S. E.; Alaboalirat, M.; Eades, C. B.; Scannelli, S. J.; Matson, J. B.Macromolecules 2022, 55, 3522-3532 DOI: 10.1021/acs.macromol.2c00254 Green-light-responsive metal–organic frameworks for colorectal cancer treatment Cornell, H. D.; Zhu, Y.; Ilic, S.; Lidman, N. E.; Yang, X.; Matson, J. B.; Morris, A. J.Chem. Commun. 2022, 58, 5225-5228 DOI: 10.1039/D2CC00591C Poly(β-cyclodextrin) prepared by ring-opening metathesis polymerization enables creation of supramolecular polymeric networks Alaboalirat, M.; Matson J. B. ACS Macro Lett. 2021, 10, 1460-1466 DOI: 10.1021/acsmacrolett.1c00590 Strong variation of micelle-unimer coexistence as a function of core chain mobility Carrazzone, R. J.; Li, X.; Foster, J. C.; Uppala, V. V. S.; Wall, C. E.; Esker, A. E.; Madsen, L. A.; Matson, J. B.Macromolecules 2021, 54, 6975-6981 DOI: 10.1021/acs.macromol.1c00635 A review of chemical tools for studying small molecule persulfides: detection and delivery Dillon, K. M.; Matson, J. B. ACS Chem. Biol. 2021, 16, 1128-1141 DOI: 10.1021/acschembio.1c00255 Amino acid-based H2S donors: N-thiocarboxyanhydrides that release H2S with innocuous byproducts Kaur, K.; Enders, P.; Zhu, Y.; Bratton, A. F.; Powell, C. R.; Kashfi, K.; Matson, J. B.Chem. Commun. 2021, 57, 5522-5525 DOI: 10.1039/D1CC01309B Targeted delivery of persulfides to the gut: Effects on the microbiome Dillon, K M.; Morrison, H. A.; Powell, C. R.; Carrazzone, R. J.; Ringel-Scaia, V. M.; Winckler, E. W.; Council-Troche, R. M.; Allen, I. C.; Matson, J. B. Angew. Chem. Int. Ed. 2021, 60, 2-9 DOI: 10.1002/anie.202014052 Novel electrospun pullulan fibers incorporating hydroxypropyl-β-cyclodextrin: morphology and relation with rheological properties Poudel, D.; Swilley-Sanchez, S.; O’keefe, S.; Matson, J. B.; Long, T. E.; Fernandez-Fraguas, C.Polymers 2020, 12, 2558 DOI: 10.3390/polym12112558 Crescent-shaped supramolecular tetrapeptide nanostructures Wang, Y.; Li, Z.; Carrazzone, R. J.; Bitton, R.; Matson, J. B.J. Am. Chem. Soc. 2020, 142, 20058 DOI: 10.1021/jacs.0c09399 Tuning small molecule release from polymer micelles: Varying H2S release through crosslinking in the micelle core Carrazzone, R. J.; Foster, J. C.; Li, Z.; Matson, J. B.Eur. Polym. J. 2020, 141, 110077 DOI: 10.1016/j.europolymj.2020.110077 A combined experimental and computation approach reveals how aromatic peptide amphiphiles self-assemble to form ion-conducting nanohelices Wang, Y.; An, Y.; Shmidov, Y.; Bitton, R.; Deshmukh, S. A.; Matson, J. B.Mater. Chem. Front. 2020, 4, 3022-3031 DOI: 10.1039/D0QM00369G Effect of Crosslinker Topology on Enzymatic Degradation of Hydrogels Shmidov, Y.; Zhu, Y.; Matson, J. B.; Bitton, R.Biomacromolecules 2020, 21, 3279-3286 DOI: 10.1021/acs.biomac.0c00722 Alleviating Oxidative Stress through Treatment with Superoxide-Triggered Persulfide Prodrugs Wang, Y.; Dillon, K. M.; Li, Z.; Winckler, E. W.; Matson, J. B. Angew. Chem. Int. Ed. 2020, 59, 16698-16704 DOI: 10.1002/anie.202006656 Quo Vadis, Macromolecular Science? Reflections by the IUPAC Polymer Division on the Occasion of the Staudinger Centenary Abetz, V.; Chan C. H.; Luscombe, C. K.; Matson, J. B.; Merna, J.; Nakano, T.; Raos, G.; Russell, G. T.Isr. J. Chem. 2020, 60, 9-19 DOI: 10.1002/ijch.201900182 Molecular-Level Control over Plasmonic Properties in Silver Nanoparticle/Self-Assembling Peptide Hybrids Wang, Y.; Yang, X.; Liu, T.; Li, Z.; Leskauskas, D.; Liu, G.; Matson, J. B.J. Am. Chem. Soc. 2020, 142, 9158-9162 DOI: 10.1021/jacs.0c03672 Polymeric Persulfide Prodrugs: Mitigating Oxidative Stress through Controlled Delivery of Reactive Sulfur Species Dillon, K. M.; Carrazzone, R. J.; Wang, Y.; Powell, C. R.; Matson, J. B. ACS Macro Lett. 2020, 9, 606-612 DOI: 10.1021/acsmacrolett.0c00118 The evolving landscape for cellular nitric oxide and hydrogen sulfide delivery systems: A new era of customized medications Dillon, K. M.; Carrazzone, R. J.; Matson, J. B.; Kashfi, K.Biochemical Pharmacology 2020, 176, 113931 DOI: 10.1016/j.bcp.2020.113931 H2S-releasing amphiphilic dipeptide hydrogels are potent S. aureus biofilm disruptors Qian, Y.; Altamimi, A.; Yates, S. A.; Sarkar, S.; Cochran, M.; Zhou, M.; Levi-Polyachenko, N.; Matson, J. B.Biomater. Sci. 2020, 8, 2564-2576 DOI: 10.1039/D0BM00241K Linker-Regulated H2S Release from Aromatic Peptide Amphiphile Hydrogels Kaur, K.; Wang, Y.; Matson, J. B.Biomacromolecules 2020, 21, 1171-1178 DOI: 10.1021/acs.biomac.9b01600 Elastase-triggered H2S delivery from polymer hydrogels Zhou, M.; Qian, Y.; Zhu, Y.; Matson, J. B.Chem. Commun. 2020, 56, 1085-1088 DOI: 10.1039/C9CC08752D The benefits of macromolecular/supramolecular approaches in hydrogen sulfide delivery: A review of polymeric and self-assembled hydrogen sulfide donors Kaur, K.; Carrazzone, R. J.; Matson, J. B.Antioxid. Redox Sign., 2020, 32,79-95 DOI: 10.1089/ars.2019.7864 EphA4/Tie2 crosstalk regulates leptomeningeal collateral remodeling following ischemic stroke Okyere, B.; Mills III, W. A.; Wang, X.; Chen, M.; Chen, J.; Hazy, A.; Qian, Y.; Matson, J. B.; Theus, M. H.J. Clin. Invest., 2020, 130, 1024-1035 DOI: 10.1172/JCI131493 Polysaccharide-containing block copolymers: synthesis and applications Volokhova, A. S.; Edgar, K. J.; Matson, J. B.Mater. Chem. Front., 2020, 4, 99-112 DOI: 10.1039/C9QM00481E Peripheral Loss of EphA4 Ameliorates TBI-Induced Neuroinflammation and Tissue Damage Kowalski, E. A.; Chen, J.; Hazy, A.; Fritsch, L. E.; Gudenschwager-Basso, E. K.; Chen, M.; Wang, X.; Qian, Y.; Zhou, M.; Byerly, M.; Pickrell A. M.; Matson, J. B.; Allen, I. C.; Theus, M. H.J. Neuroinflammation, 2019, 16, 210 DOI: 10.1186/s12974-019-1605-2 Enzyme-induced in vivo assembly of gold nanoparticles for imaging-guided synergistic chemo-photothermal therapy of tumor Yang, K.; Liu, Y.; Wang, Y.; Ren, Q.; Guo, H.; Matson, J. B.; Chen, X., Nie, Z.Biomaterials, 2019, 223, 119460 DOI: 10.1016/j.biomaterials.2019.119460 Supramolecular Nanostructures with Tunable Donor Loading for Controlled H2S Release Wang, Y.; Matson, J. B. ACS Appl. Bio. Mater., 2019, 2, 5093-5098 DOI: 10.1021/acsabm.9b00768 Hydrogen Sulfide-Releasing Peptide Hydrogel Limits the Development of Intimal Hyperplasia in Human Vein Segments Longchamp, A.; Kaur, K.; Macabrey, D.; Dubuis, C.; Corpataux, J.; Déglise, S.; Matson, J.B.; Allagnat, F.Acta Biomater., 2019, 97, 374-384 DOI: 10.1016/j.actbio.2019.07.042 Functional N-Substituted N-Thiocarboxyanhydrides as Modular Tools for Constructing H2S Donor Conjugates Powell, C. R.; Kaur, K.; Dillon, K. M.; Zhou, M.; Alaboalirat, M. Matson, J. B. ACS Chem. Biol., 2019, 14, 1129-1134 DOI: 10.1021/acschembio.9b00248 Self-Amplified Depolymerization of Oligo(thiourethanes) for Release of COS/H2S Powell, C. R.; Foster, J. C.; Swilley, S. N.; Scannelli, S. J.; Troya, D.; Matson, J. B.Polym. Chem., 2019, 10, 2991-2995 DOI: 10.1039/C9PY00354A Toughening Cellulose: Compatibilizing Polybutadiene and Cellulose Triacetate Blends Arrington, K. J.; Haag, J. V.; French, E. V.; Murayama, M.; Edgar, K. J.; Matson, J. B. ACS Macro Letters, 2019, 8, 447-453 DOI: 10.1021/acsmacrolett.9b00136 Effects of Graft Polymer Compatibilizers in Blends of Cellulose Triacetate and Poly(Lactic Acid) Volokhova, A. S.; Waugh, J. B.; Arrington, K. J.; Matson, J. B.Polym. Int., 2019, 68, 1263-1270 DOI: 10.1002/pi.5820 Tuning H2S Release by Controlling Mobility in a Micelle Core Foster, J. C.; Carrazzone, R. J.; Spear, N. J.; Radzinski, S. C.; Arrington, K. J.; Matson, J. B.Macromolecules, 2019, 52, 1104-1111 DOI: 10.1021/acs.macromol.8b02315 Supramolecular Tuning of H2S Release from Aromatic Peptide Amphiphile Gels: Effects of Core Unit Substituents Qian, Y.; Kaur, K.; Foster, J. C.; Matson, J. B.Biomacromolecules, 2019, 20, 1077-1086 DOI: 10.1021/acs.biomac.8b01732 Self-Immolative Prodrugs: Effective Tools for the Controlled Release of Sulfur Signaling Species Dillon, K. M.; Powell, C. R.; Matson, J. B.Synlett., 2019, 30, 525-531 DOI: 10.1055/s-0037-1611693 Hydrogels Composed of Hyaluronic Acid and Dendritic ELPs: Hierarchical Structure and Physical Properties Shmidov, Y.; Zhou, M.; Yosefi, G.; Bitton, R.; Matson, J. B.Soft Matter, 2019, 15, 917-925 DOI: 10.1039/C8SM02450B Amphiphilic Bottlebrush Block Copolymers: Analysis of Aqueous Self-Assembly by Small-Angle Neutron Scattering and Surface Tension Measurements Alaboalirat, M.; Qi, L.; Arrington, K. J.; Qian, S.; Keum, J. K.; Me, H.; Littrell, K. C.; Sumpter, B. G.; Carrillo, J. Y.; Verduzco, R.; Matson, J. B.Macromolecules, 2019, 52, 465-476 DOI: 10.1021/acs.macromol.8b02366 Self-Assembled Nanostructures Regulate H2S Release from Constitutionally Isomeric Peptides Wang, Y.; Kaur, K.; Scannelli, S. J.; Bitton, R.; Matson, J. B.J. Am. Chem. Soc., 2018, 140, 14945–14951 DOI: 10.1021/jacs.8b09320 Hydrolytic Decomposition of S-Aroylthiooximes: Effect of pH and N-Arylidene Substitution on Reaction Rate Kaur, K.; Qian, Y.; Gandour, R. D.; Matson, J. B.J. Org. Chem., 2018, 83, 13363–13369 DOI: 10.1021/acsami.8b08480 Reversibly Cross-Linkable Bottlebrush Polymers as Pressure-Sensitive Adhesives Arrington, K. J.; Radzinski, S. C.; Drummey, K. J.; Long, T. E.; Matson, J. B. ACS Appl. Mater. Interfaces, 2018, 10, 26662–26668 DOI: 10.1021/acsami.8b08480 A Persulfide Donor Responsive to Reactive Oxygen Species: Insights into Reactivity and Therapeutic Potential Powell, C. R.; Dillon, K. M.; Wang, Y.; Carrazzone, R. J.; Matson, J. B. Angew. Chem. Int. Ed., 2018, 57, 6324-6328 DOI: 10.1002/anie.201803087 Book Chapter: “H2S Delivery from Aromatic Peptide Amphiphile Hydrogels” Biomaterials for Tissue Engineering: Methods and Protocols Kaur, K.; Qian, Y.; Matson, J. B.Springer, New York, 2018, 193-208 DOI: 10.1007/978-1-4939-7741-3_15 A Review of Hydrogen Sulfide (H2S) Donors: Chemistry and Potential Therapeutic Applications Powell, C. R.; Dillon, K. M.; Matson, J. B.Biochem. Pharmacol., 2018, 149, 110-123 DOI: 10.1016/j.bcp.2017.11.014