Neufeld, Ronald J - Queen's University - Department of Chemical Engineering

个人简介

Sustained delivery of molecular-targeting therapeutics in cancer treatment Prof. Myron Szewczuk, Department of Biomedical and Molecular Sciences, Queen's University Prof. Dérick Rousseau, Department of Chemistry and Biology, Ryerson University Hybrid biomaterials for self-assembly and controlled release Prof. Michael Cunningham, Department of Chemical Engineering, Queen's Prof. Pascale Champagne, Department of Civil Engineering, Queen's Prof. Ralph Whitney, Department of Chemistry, Queen's Long term sustained delivery of growth factors for treatment of burn wounds Prof. Manuela Martins-Green, Department of Cell Biology and Neuroscience, University of California, Riverside Prof. Annelise Barron, Department of Bioengineering, Stanford University Extracellular matrix-based micro and nanofibre microbead scaffold for cell growth and implantation Dr. Jean-Pierre Hallé and Dr. Euridice Carmona, Maisonneuve-Rosemont Hospital, Laboratory for Bioartificial Therapies, Montreal Prof. Annelise Barron, Department of Bioengineering, Stanford University Oral delivery of nanoparticulate insulin in control of diabetes Dr. Christiane Damgé, Université Louis Pasteur, Strasbourg, France Prof. Catarina Pinto Reis, Laboratory of Nanoscience and Biomedical Nanotechnology, ULHT, Lisbon Prof. Bruno Sarmento, Instituto Nacional de Engenharia Biomédica, Porto Design fundamentals for encapsulation processes Prof. Denis Poncelet, ONIRIS, Nantes, France

研究领域

The micro- and nanoencapsulation of biologically active materials enables stabilization, retention, immunoprotection, controlled or targeted delivery, and cell growth in a protected environment. Cells, tissues and bioactives that we have experience with include mammalian cells, microorganisms, enzymes, nucleotides, genomic DNA, therapeutic peptides and growth factors, and molecular-targeting therapeutics directed toward growth factor receptors. As tissues and biologicals are labile, encapsulation matrix/membrane materials and methods often involve use of natural polymers such as polysaccharides and proteins, thus avoiding the use of solvents, pH extremes and highly reactive polymerization conditions. The control of polymer matrix/membrane properties achieve specific therapeutic goals, such as bioactive retention and protection in the gastrointestinal tract, mucoadhesion and translocation across the intestinal membrane, and thus oral delivery of a protein-based drug as an example. This research is interdisciplinary and collaborative, thus graduate students and researchers have opportunity to conduct research in collaborating labs. Recent and active research areas are listed below, with names of collaborators.

近期论文

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Akasov, R., S. Haq, F. Haxho, V. Samuel, S.V. Burov, E. Markvicheva, R.J. Neufeld and M.R. Szewczuk. 2016. Sialylation transmogrifies human breast and pancreatic cancer cells into 3D multicellular tumor spheroids using cyclic RGD-peptide induced self-assembly. Oncotarget, 5: http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=11868 Kapishon, V., S. Allison, R.A. Whitney, M.F. Cunningham, M. Szewczuk and R.J. Neufeld. 2016. Oseltamivir-conjugated polymeric micelles prepared by RAFT living radical polymerization as a new active tumor targeting drug delivery platform. Biomaterials Science, 4: 511-521. Dhall, S., J.P. Silva, Y. Liu, M. Hrynyk, M. Garcia, A. Chan, J. Lyubovitsky, R.J. Neufeld and M. Martins-Green. 2015. Release of insulin from PLGA-alginate dressing stimulates regenerative healing of burn wounds in rats. Clinical Science, 129: 1115-1129. Hrynyk, M., J.P. Ellis, F. Haxho, S. Allison, J.A.M. Steele, S. Abdulkhalek, R.J. Neufeld and M.R. Szewczuk. 2015. Therapeutic designed poly (lactic-co-glycolic acid) cylindrical oseltamivir phosphate-loaded implants impede tumor neovascularization, growth and metastasis in mouse model of human pancreatic carcinoma. Drug Design, Development and Therapy, 9: 4573-4586. Kapishon, V., R. Whitney, P. Champagne, M.F. Cunningham and R.J. Neufeld. 2015. Polymerization induced self-assembly of alginate based amphiphilic graft copolymers synthesized by single electron transfer living radical polymerization. Biomacromolecules, 16: 2040-2048. (ACS Editor’s Choice and amongst top 10 most read papers in journal over past 12 months). Perignon, C., G. Ongmayeb, R.J. Neufeld, Y. Frere and D. Poncelet. 2015. Microencapsulation by interfacial polymerization: Membrane formation and structure. J. Microencapsulation, 32: 1-15. Haxho, F., S. Allison, F. Alghamdi, L. Brodhagen, V. Kuta, S. Abdulkhalek, R.J. Neufeld and M.R. Szewczuk. 2014. Oseltamivir phosphate monotherapy ablates tumor neovascularization, growth and metastasis in mouse model of human triple-negative breast adenocarcinoma. Breast Cancer: Targets and Therapy, 6: 191-203. Abdulkhalek, S., O. Geen, L. Brodhagen, F. Haxho, F. Alghamdi, S. Allison, D. Simmons, R.J. Neufeld and M.R. Szewczuk. 2014. Transcriptional factor snail controls tumor neovascularization, growth and metastasis in mouse model of human ovarian carcinoma. Clinical and Translational Medicine, 3:28-43. Aziz, S., J. Gill, P.R.L. Dutilleul, R.J. Neufeld and S. Kermasha. 2014. Microencapsulation of krill oil using complex coacervation. J. Microencapsul., 31: 774-784. (Most downloaded paper in journal for 2015) O'Shea, L.K., S. Abdulkhalek, S. Allison, R.J. Neufeld and M.R. Szewczuk. 2014. Therapeutic targeting of Neu1 sialidase with oseltamivir phosphate (Tamiflu®) disables cancer cell survival in human pancreatic cancer with acquired chemoresistance. OncoTargets and Therapy, 7: 117-134. Bowey, K., B. Swift, L.E. Flynn and R.J. Neufeld. 2013. Characterization of biologically active insulin-loaded alginate microparticles prepared by spray drying. Drug Development and Industrial Pharmacy, 39: 457-465. Steele, J.A.M., A.E. Barron, E. Carmona, J-P. Hallé and R.J. Neufeld. 2012. Encapsulation of protein microfiber networks supporting pancreatic islets. Journal of Biomedical Materials Research: Part A,100: 3384-3391. Hrynyk, M., M. Martins-Green, A.E. Barron and R.J. Neufeld. 2012. Alginate-PEG sponge architecture and role in the design of insulin release dressings. Biomacromolecules, 13: 1478-1485. Woitiski, C.B., R.J. Neufeld, A.F. Soares, I.V. Figueiredo, F. Veiga and R.A. Carvalho. 2012. Evaluation of hepatic glucose metabolism via gluconeogenesis and glycogenolysis after oral administration of insulin nanoparticles. Drug Development and Industrial Pharmacy, 38: 1441-1450.. Pinto Reis, C., R.J. Neufeld, F. Veiga, I.V. Figueiredo, J. Jones, A.F. Soares, P. Nunes, C. Damgé and R.A. Carvalho.2012. Effects of an oral insulin nanoplex on hepatic glucose metabolism assessed by 13C and 2H isotopomer analysis. J. Microencapsulation, 29: 167-176. Woitiski, C.B., B. Sarmento, R.A. Carvalho, R.J. Neufeld and F. Veiga. 2011. Facilitated nanoscale delivery of insulin across intestinal membrane models. International Journal of Pharmaceutics, 412: 123-131. Erdinc, B. and R.J. Neufeld. 2011. Protein micro and nanoencapsulation within glycol chitosan/Ca2+/alginate matrix by spray drying. Drug Development and Industrial Pharmacy, 37(6): 619-627. Woitiski, C.B., R.J. Neufeld, F. Veiga, R.A. Carvalho and I.V. Figueiredo. 2010. Pharmacological effect of orally delivered insulin facilitated by multilayered stable nanoparticles. European Journal of Pharmaceutical Sciences, 41: 556-563. Chan, A and R.J. Neufeld. 2010. Tuneable semi-synthetic alginate for absorptive encapsulation and controlled release of protein therapeutics. Biomaterials, 31: 9040-9047. Hrynyk, M., M. Martins-Green, A.E. Barron and R.J. Neufeld. 2010. Sustained and prolonged topical delivery of bioactive human insulin for potential treatment of cutaneous wounds. International Journal of Pharmaceutics, 398: 146-154. Chan, A. and R.J. Neufeld. 2009. Modeling the controllable pH-responsive swelling and pore size of networked alginate based biomaterials. Biomaterials, 30: 6119-6129. Woitiski, C.B., F. Veiga, A.J. Ribeiro and R.J. Neufeld. 2009. Design for optimization of nanoparticles integrating biomaterials for orally dosed insulin. European Journal of Pharmaceutics and Biopharmaceutics, 73: 25-33. Woitiski, C.B., R.J. Neufeld, A.J. Ribeiro and F. Veiga. 2009. Colloidal carrier integrating biomaterials for oral insulin delivery: Influence of component formulation on physicochemical and biological parameters. Acta Biomaterialia, 5: 2475-2484. Chan, A.W., R.A. Whitney and R.J. Neufeld. 2009. Semisynthesis of a controlled stimuli-responsive alginate hydrogel. Biomacromolecules, 10: 609-616. Reis, C.P., I.V. Figueiredo, R.A Carvalho, J. Jones, P. Nunes, A.F. Soares, C.F. Silva, A.J. Ribeiro, F.J. Veiga, C. Damgé, A.M.S. Cabrita and R.J. Neufeld. 2008. Toxicological assessment of orally delivered nanoparticulate insulin. Nanotoxicology, 2: 206-217.