Fitzpatrick, Lindsay - Queen's University - Department of Chemical Engineering

个人简介

Education Postdoc - Georgia Institute of Technology (2013) PhD - University of Toronto (2012) B.Eng and Biosciences - McMaster University (2006) Funding Queen's University NSERC (Discovery) Canada Foundation for Innovation (JELF) Ontario Ministry of Research and Innovation (ORF)

研究领域

My research program explores the interactions among biomaterials, innate immune cells and adsorbed proteins to better understand the underlying mechanisms that drive host responses to implanted biomedical materials and devices. Specifically, we are interested in defining the contributions tissue-derived proteins and other macromolecules within adsorbed protein layers on biomaterial surfaces, and studying activation of pattern recognition pathways in responding inflammatory cells, such as macrophages. The goal of our research is advance biomaterial science and improve material-tissue integration by better understanding the mechanisms driving host responses and foreign body reactions. In parallel, we are also developing rapid-throughput models for screening novel biomaterial candidates through non-invasive imaging to assess biocompatibility and host responses, as well as in vivo material characterization. Fitzpatrick Lab trainees are eligible to apply to the Queen's Collaborative Biomedical Engineering (CBME) graduate program.

近期论文

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Fitzpatrick LE*, McDevitt TC. (2015) Cell-derived matrices for tissue engineering and regenerative medicine applications. Biomaterials Science. 3(1): 12-24. Recommended in F1000Prime as being of special significance in its field Top 20 most-accessed Biomaterials Science articles in 2015; Top 10 Most-accessed Biomaterials Science articles – Q1 2016 Fitzpatrick LE, Lisovsky A and Sefton MV. (2012) The expression of sonic hedgehog in diabetic wounds following treatment with poly(methacrylic acid-co-methyl methacrylate) beads. Biomaterials 33(21):5297-5307. Fitzpatrick SD, Fitzpatrick LE, Thakur A, Mazumder MAJ and Sheardown H. (2012) Temperature-sensitive polymers for drug delivery. Expert Review of Medical Devices 9(4):339-351. Fitzpatrick LE, Chan JWY and Sefton MV. (2011) On the mechanism of poly(methacrylic acid –co– methyl methacrylate)-induced angiogenesis: gene expression analysis of dTHP-1 cells. Biomaterials32(34): 8957-8967. Corstorphine L and Sefton MV. (2011) Effectiveness factor and diffusion limitations in collagen gel modules containing HepG2 cells. Journal of tissue engineering and regenerative medicine5(2): 119-129. Fitzpatrick SD, Jafar Mazumder MA, Lasowski F, Fitzpatrick LE, Sheardown H. (2010) PNIPAAm-grafted-collagen as an injectable, in situ gelling, bioactive cell delivery scaffold. Biomacromolecules. 11(9): 2261-2267. Chamberlain MD, Butler MJ, Ciucurel EC, Fitzpatrick LE, Khan OF, Leung BM, Lo C, Patel R, Velchinskaya A, Voice DN, Sefton MV. (2010) Fabrication of micro-tissues using modules of collagen gel containing cells. Journal of Visualized Experiments. 13;(46).