个人简介

Funding The financial support received from the following sources is greatly acknowledged: Queen's University NSERC (CRC Tier II, Discovery, RTI) Canada Foundation for Innovation Ontario Innovation Trust Materials & Manufacturing Ontario (EMK, Sectorial, and Interact programs) Novelis, Inc. Movies: Electrokinetic Assembly of Silica Particles I: Low Concentrations Electrokinetic Assembly of Silica Particles II: Higher Concentrations Older Movies Particle dispersion in triangular electrodes Particle dispersion in circular electrodes

研究领域

The ultimate goal is the development of products and manufacturing processes of technological importance in the areas of Advanced Materials, related to applications in Nanotechnology and Biomaterials. The research program follows two main directions: Development of methodologies and process design tools for the synthesis of advanced materials through non-uniform electric field-directed organization of nanometre-sized particles into well-defined one-, and multi-dimensional structures, with prescribed length scales and composition. Implementation of novel concepts for surface-engineering design and performance assessment of biocompatible materials, as well as systematic studies of the interactions between blood components (such as proteins) and the latter.

The research interests of Dr. Docoslis lie in the fields of Colloid Science and Interfacial Engineering and are centered toward the understanding, exploitation, and modulation of colloidal interactions that occur between nanoscopic materials (nanoparticles, macromolecules) in solution or at interfaces. Specific interests include self- and directed assembly of colloidal systems into multi-dimensional structures that combine functionality and long-range order. Synthesis of functional structures with nanometre-scale order; Nanotechnology Electrically conducting polymer nano-composites Development of methods for rapid, in situ detection of virus in surface-based biosensors Surface and material characterization using Raman micro-spectroscopy Colloidal interactions and self-assembly in aqueous and organic media Kinetics and thermodynamics of biopolymer adsorption Fabrication of micro-electromechanical systems (MEMS) Development of surface-engineered biocompatible materials

近期论文

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G.Z. Papageorgiou, S. Papadimitriou, E. Karavas, E. Georgarakis, A. Docoslis, D. Bikiaris, "Improvement in Chemical and Physical Stability of Fluvastatin Drug Through Hydrogen Bonding Interactions with Different Polymer Matrices," Current Drug Delivery2009. (Accepted) G. Z. Papageorgiou, A. Docoslis, M. Georgarakis, D. Bikiaris, "The Effect of Physical State on the Drug Dissolution Rate: Miscibility studies of Nimodipine with PVP," Journal of Thermal Analysis and Calorimetry 95, 903-915, 2009. Kontopoulou M., Kaufman M., Docoslis A., "Electrorheological properties of PDMS/carbon black suspensions under shear flow,"Rheologica Acta 2008. (Accepted) Vassiliou A, Biklaris D, Chrissafis K, Paraskevopoulos KM, Stavrev SY, Docoslis A, "Nanocomposites of isotactic polypropylene with carbon nanoparticles exhibiting enhanced stiffness, thermal stability and gas barrier properties ," Composites Science and Technology 68, 3-4, 933-943 , 2008. Bikiaris, D.; Vassiliou, A.; Chrissafis, K.; Paraskevopoulos, K. M.; Jannakoudakis, A.; Docoslis, A. , "Effect of acid treated multiwall carbon nanotubes on the mechanical, permeability, thermal properties and thermo-oxidative stability of isotactic polypropylene,"Polymer Degradation and Stability 93, 5, 952-967 , 2008. F. L-Y Yuen; G. Zak; S. D. Waldman; A. Docoslis, "Morphology of fibroblasts grown on substrates formed by dielectrophoretically aligned carbon nanotubes," Cytotechnology 56, 1, 9-17, 2008. M. R. Tomkins, J. A. Wood, and A. Docoslis, "Observation and Analysis of Electrokinetically Driven Particle Trapping in Planar Microelectrode Arrays," Canadian Journal of Chemical Engineering 86, 4, 609-621 , 2008. Chrissafis, K.; Paraskevopoulos, K. M.; Stavrev, S. Y.; Docoslis, A.; Vassiliou, A.; Bikiaris, D. , "Characterization and thermal degradation mechanism of isotactic polypropylene/carbon black nanocomposites," Thermochimica Acta 465, 6-17, 2007. A. Docoslis, K. L. Huszarik, G. Z. Papageorgiou, D. Bikiaris, and E. Georgarakis, "Characterization of the distribution, polymorphism, and stability of nimodipine in its solid dispersions in PEG by micro-Raman spectroscopy and powder XRD ," AAPS Journal 9, No. 43, 2007. E. Karavas, E. Georgarakis, A. Docoslis, D. Bikiaris, "Combining SEM, TEM, and micro-Raman techniques to differentiate between the amorphous molecular level dispersions and nanodispersions of a poorly-water soluble drug within a polymer matrix,"International Journal of Pharmaceutics doi:10.1016/j.ijpharm.2007.03.037, 2007. Z. Guo, J. A. Wood, K. L. Huszarik, X. Yan, A. Docoslis, "AC electric field-induced alignment and long-range assembly of multiwall carbon nanotubes inside aqueous media," Journal of Nanoscience and Nanotechnology 7, 4322-4332, 2007. A. Docoslis, L. A. Tercero Espinoza, B. Zhang, L.-L. Cheng, B. A. Israel, P. Alexandridis, and N. L. Abbott, "Using Non-uniform Electric Fields to Accelerate the Transport of Viruses to Surfaces from Media of Physiological Ionic Strength," Langmuir 23, 3840-3848, 2007. J. A. Wood, B. Zhang, M. R. Tomkins, and A. Docoslis, "Numerical investigation of AC electrokinetic virus trapping inside high ionic strength media," Microfluidics and Nanofluidics 3, 5, 547-560, 2007. G. Z. Papageorgiou, D. Bikiaris, E. Pavlidou, A. Stergiou, Y. Park, A. Docoslis, E. Karavas, E. Georgarakis, "Dissolution rate enhancement of Nimodipine via nano-dispersion in PVP. Physical characterization of the mixtures by TEM and micro-Raman spectroscopy," Materials Science & Engineering C 2006. (Accepted) G. Z. Papageorgiou, D. Bikiaris, E. Karavas, S. Politis, A. Docoslis, Y. Park, A. Stergiou, and E. Georgarakis, "Effect of Physical State and Particle Size Distribution on Dissolution Enhancement of Nimodipine/PEG Solid Dispersions Prepared by Melt Mixing and Solvent Evaporation," AAPS PharmSci 8, 4, E623-E631, 2006. Van Oss, C. J.; Giese, R. F.; Docoslis, A., "Hyperhydrophobicity of the Water-Air Interface," Journal of Dispersion Science and Technology 26, 585, 2005. Docoslis, A.; Tercero-Espinoza, L. A.; Israel, B., A.; Abbott, N. L.; Alexandridis, P., "Dielectrophoretic Capture of Viral Particles from Media of Physiological Ionic Strength," AIChE Conference Proceedings 79, 2004. Van Oss, C. J.; Giese, R. F.; Docoslis, A., "Impact of Experimental and Instrumental Conditions on the Measured Results of Kinetic and Equilibrium Constant Determinations Involving Biopolymers," Journal of Biological Physics and Chemistry 4, 145, 2004. Van Oss, C. J.; Giese, R. F.; Bronson, P. M.; Docoslis, A.; Edwards, P.; Ruyechan, W. T., "Microscopic-scale surface properties of streptavidin and their influence on aspecific interactions between streptavidin and dissolved biopolymers," Colloids and Surfaces B: Biointerfaces 30, 25-36, 2003. Docoslis, A.; Alexandridis, P., "Electric Field Simulations for the Prediction of Dielectrophoretic Forces in the Nanoscale," 2nd Topical Conference on Nanometer Scale Science and Engineering AIChE Pub. No. P-168, 163-173, 2002. Docoslis, A.; Alexandridis, P., "One-, two-, and three-dimensional organization of colloidal particles using non-uniform AC electric fields," Electrophoresis 23, 2174-2183, 2002. Docoslis, A.; Alexandridis, P., "Manipulation of Nanoparticles via the Utilization of Non-Uniform AC Electric Fileds," Annual Meeting of the American Electrophoresis Society AIChE Pub. No. 148, 91-102, 2001. van Oss, C. J.; Giese, R. F.; Docoslis, A., "Water, treated as the continuous liquid in and around cells," Cellular and Molecular Biology 47, 721-733, 2001. Docoslis, A.; Wu, W.; Giese, R. F.; van Oss, C. J., "Influence of macroscopic and microscopic interactions on kinetic rate constants. III. Determination of von Smoluchowski's f-factor for HSA adsorption onto various metal oxide microparticles, using the extended DLVO approach," Colloids and Surfaces B: Biointerfaces 22, 205-217, 2001. Docoslis, A; Rusinski, L. A.; Giese, R. F.; van Oss, C. J., "Kinetics and interaction constants of protein adsorption onto mineral microparticles. -Measurements of the constants at the onset of hysteresis," Colloids and Surfaces B: Biointerfaces 22, 267-283, 2001.