Daugulis, Andrew - Queen's University - Department of Chemical Engineering

个人简介

A number of research projects are currently under investigation in my laboratory in the areas of Biochemical and Cell Culture Engineering, focused on developing novel bioprocesses for both environmental and biotechnology applications. The research from our laboratory has created a Technology Platform known as two-phase partitioning bioreactors (TPPBs), which has now been adopted by Research Groups in more than 20 countries around the world, and has led to US/Canadian patents and commercial licenses. Since the performance of many bioprocesses is limited by the presence of toxic molecules, our strategy has been to introduce an immiscible second phase into a bioreactor, whose function is to selectively partition toxic substrates either to the microorganisms in degradative reactions, or toxic products away from the microorganisms in synthesis reactions (hence "TPPB"). In this way the microenvironment of cells is effectively detoxified of inhibitory substrates and/or products, resulting in significantly enhanced cell, and therefore process, performance. Successful examples have included the production of (inhibitory) biofuels such as ethanol and acetone/butanol, and the biodestruction of toxic substrates such as substituted phenols, endocrine disruptors, and PCBs. Environmental TPPB projects currently underway include the treatment of recalcitrant xenobiotics such as are present in fracking fluids, while Biotechnology TPPB applications include the biosynthetic production of commercially important high value neutraceuticals and biopharmaceutical precursor molecules. Through the application of rigorous thermodynamic predictions and experimental validation, the active sequestering phases in TPPBs in our laboratory now include immiscible organic solvents, ionic liquids, amorphous polymers, and ionomeric materials all acting to detoxify, and greatly enhance, bioprocess performance. Editorial Board Activities Editor, Journal of Hazardous Materials Advisory Editorial Board, Journal of Chemical Technology and Biotechnology Editorial Board, Biodegradation Editorial Board, Biotechnology Letters Editorial Board, Environmental Engineering and Management Journal Funding NSERC (Discovery, Strategic and CRD Grants), Scientific Applications International Corporation (SAIC Canada), E.I. DuPont de Nemours and Company (Wilmington DE), DuPont (Canada), Kingston Process Metallurgy

研究领域

Two-Phase Partitioning Bioreactors (TPPBs) TPPBs for Production of Neutraceuticals, Chiral Compounds and Biofuels Treatment of Xenobiotic Compounds (gas/liquid/solid) in Partitioning Bioreactors Bioprocess Development Modelling and Simulation of Bioprocesses

近期论文

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Tomei, M.C., Mosca Angelucci, D. and Daugulis, A.J., A Novel Continuous Two-Phase Partitioning Bioreactor Operated With Polymeric Tubing: Performance Validation for Enhanced Biological Removal of Toxic Substrates, J. Env. Management, 187, 265-272 (2016). (More Information) Bacon, S.L., Daugulis, A.J. and Parent, J.S., Isobutylene-rich imidazolium ionomers for use in two-phase partitioning bioreactors, Green Chemistry, 18, 6586-6595 (2016). (More Information) Tomei, M.C., Angelucci, D.M and Daugulis, A.J., Sequential Anaerobic-aerobic Decolourization of a Real Textile Wastewater in a Two-Phase Partitioning Bioreactor, Science of the Total Environment, 573, 585-593 (2016). (More Information) Kleczek, M.R., Whitney, R.A., Daugulis, A.J. and Parent, J.S., Synthesis and Characterization of Thermoset Imidazolium Bromide Ionomers, Reactive and Functional Polymers, 106, 69-75, (2016) (More Information). Tomei, M.C., Angelucci, D.M. and Daugulis, A.J., Towards a Continuous Two-Phase Partitioning Bioreactor for Xenobiotic Removal, J. Haz Mat., 317, 403-415, (2016). (More Information). Ma, X-k, Ding, N., Peterson, E.C., and Daugulis, A.J. Heavy Metals Species Affect Fungal-Bacterial Synergism During the Bioremediation of Fluoranthene, Appl. Microbiol. Biotechnol., 100, 7741-7750, (2016) (More Information). Bacon, S.L., Daugulis, A.J. and Parent, J.S., Effect of Polymer Molecular Weight Distribution on Solute Sequestration in Two-Phase Partitioning Bioreactors, Chem Eng J., 299, 56-62, (2016) (More Information). Annesini, M.C., Tomei, M.C., Piemonte, V. and Daugulis, A.J. Xenobiotic Removal from Wastewater in a Two-phase Partitioning Bioreactor: Process modelling and Identification of Operational Strategies, Chem Eng J, 296, 428-436, (2016) (More Information). Peterson, E.C., Contreras-López, D., Harris, J., Parent, J.S. and Daugulis, A.J., Characterization of pH Dependence in Organic Acid Absorption with Non-reactive and Reactive Polymers for Application in Two-Phase Partitioning Bioreactors, Chem. Eng J., 287, 503-510, (2016). [More Information] Bacon, S.J., Peterson, E.C., Daugulis, A.J. and Parent J.S., Selecting Polymers for Two-Phase Partitioning Bioreactors (TPPBs): Consideration of Thermodynamic Affinity, Crystallinity and Glass Transition Temperature, Biotechnol. Prog., 31, 1500-1507, (2015). [More Information] Harris, J. and Daugulis, A.J., Biocompatibility of Low Molecular Weight Polymers for Two-Phase Partitoning Bioreactors, Biotechnol. Bioeng., 112, 2450-2458, (2015). [More Information] Pittman, M.J., Bodley, M.W. and Daugulis, A.J., Mass Transfer Considerations in Solid-Liquid Two-Phase Partitioning Bioreactors: A Polymer Selection Guide, J. Chem Technol. Biotechnol., 90, 1391-1399, (2015). [More Information] Tomei, M.C., Angelucci, D.M., Ademollo, N., and Daugulis, A.J., "Rapid and Effective Decontamination of Chlorophenol-Contaminated Soil by Sorption into Commercial Polymers: Concept Demonstration and Process Modeling", Journal of Environmental Management, 150, 81-91, 2015. [More Information] Peterson, E.C. and Daugulis, A.J., "The Use Of High Pressure CO2-Facilitated pH Swings to Enhance In Situ Product Recovery of Butyric Acid in a Two-Phase Partitioning Bioreactor," Bioitechnol. Bioeng. 111, 2183-2191, 2014. [More Information] Dafoe, J.T. Parent, J.T and Daugulis, A.J., "Block Copolymers as Sequestering Phases in Two-Phase Biotransformations: Effect of Constituent Homopolymer Properties on Solute Affinity," J. Chem. Technol. Biotechnol. 89, 1304-1310, 2014. [More Information] Bacon, S.L., Parent, J.S. and Daugulis, A.J., "A Framework to Predict and Experimentally Evaluate Polymer-Solute Thermodynamic Affinity for Two-Phase Partitioning Bioreactor (TPPB) Applications," J. Chem Technol. Biotechnol. 89, 948-956, 2014 [More information]. Craig, Y. and Daugulis, A.J., "Strategies for Improved Bioproduction of Benzaldehyde by Pichia pastoris and the Use of Hytrel as Tubing Material for Integrated Product Removal by in situ Pervaporation," Biochem. Eng. Journal 82, 97-104, 2014 [More information]. Ma, X.K. and Daugulis, A.J., "Transformation of Ferulic Acid to Vanillin Using a Fed-Batch Solid–Liquid Two-Phase Partitioning Bioreactor," Biotechnol. Progr. 30, 207-214, 2014 [More information]. Dafoe, J.T. and Daugulis, A.J., "In-situ Product Removal in Fermentation Systems: Improved Process Performance and Rational Extractant Selection," Biotechnol Letters 36, 443-460, 2014 [More information]. Ma, X. K. and Daugulis, A.J., "Effect of Bioconversion Conditions on Vanillin Production by Amycolatopsis sp. ATCC 39116 Through an Analysis of Competing By-product Formation," Bioproc Biosys Eng 37, 891-899, 2014 [More information]. Annesini, M.C., Piemonte, V., Tomei, M.C. and Daugulis, A.J., "Analysis of the performance and criteria for rational design of a Sequencing Batch Reactor for Xenobiotic Removal," Chem Eng Journal 235, 167-175, 2014 [More information]. Peterson, E.C. and Daugulis, A.J., "Demonstration of in situ Product Recovery of Butyric Acid via CO2-Facilitated pH Swings and Medium Development in Two-Phase Partitioning Bioreactors," Biotechnol. Bioeng. 111, 537-544, 2014 [More information]. Dafoe, J.T., and Daugulis, A.J., "Production of 4-valerolactone by an Equilibrium-Limited Transformation in a Partitioning Bioreactor: Impact of Absorptive Polymer Properties," Bioprocess and Biosystems Engineering 37, 533-542, 2014 [More information]. Tomei, M.C., Angelucci, D.M., and Daugulis, A.J., "The Use of Used Automobile Tires in a Partitioning Bioreactor for the Biodegradation of Xenobiotic Mixtures," Environmental Technology 35, 75-81, 2014 [More information]. Poleo, E.E. and Daugulis, A.J., "A Comparison of Three First Principles’ Methods for Predicting Solute-Polymer Affinity, and the Simultaneous Biodegradation of Phenol and Butyl Acetate in a Two-Phase Partitioning Bioreactor," Journal of Chemical Technology and Biotechnology 89, 88-96, 2014 [More information].